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Boc-o-methyl-D-serine

Boc-o-methyl-D-serine structure

CAS No.: 86123-95-7

Chemical Name:: Boc-o-methyl-D-serine

Synonyms: Boc-D-Ser(Me)-OH;BOC-O-METHYL-D-SERINE;Boc-N-D-O-methylserine;N-Boc-(D)-O-Methylserine;Boc-O-Methyl-D-serine 97%;N-Boc-O-Methyl-D-serine, 98%;(R)-N-Boc-2-aMino-3-Methoxypropionic acid;N-(tert-butoxycarbonyl)-O-methyl-D-serine;2-(tert-butoxycarbonylamino)-3-methoxypropanoic acid;D-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-

CBNumber:: CB61054969

Molecular Formula:: C9H17NO5

Molecular Weight:: 219.24

MDL Number:: MFCD08063987

MOL File:: 86123-95-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
BOC-O-METHYL-D-SERINE 97%	56482	1G	$24
BOC-O-METHYL-D-SERINE 97%	56482	5G	$77
(R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid	132113	25.00g	$158
(R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid	132113	100.00g	$378
(R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid 95+%	M38524	250mg	$16
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Boc-o-methyl-D-serine Properties

Boiling point	355.8±37.0 °C(Predicted)
Density	1.148±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.52±0.10(Predicted)
Appearance	White to light yellow Solid
optical activity	Consistent with structure
InChI	InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-14-4)7(11)12/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m1/s1
InChIKey	RFGMSGRWQUMJIR-ZCFIWIBFSA-N
SMILES	C(O)(=O)[C@@H](COC)NC(OC(C)(C)C)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2924190090

Boc-o-methyl-D-serine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	56482	BOC-O-METHYL-D-SERINE 97%	86123-95-7	1G	$24	2026-04-30	Buy
AstaTech	56482	BOC-O-METHYL-D-SERINE 97%	86123-95-7	5G	$77	2026-04-30	Buy
Matrix Scientific	132113	(R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid	86123-95-7	25.00g	$158	2026-05-18	Buy
Matrix Scientific	132113	(R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid	86123-95-7	100.00g	$378	2026-05-18	Buy
Synthonix	M38524	(R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid 95+%	86123-95-7	250mg	$16	2026-05-06	Buy

Product number	Packaging	Price	Buy
56482	1G	$24	Buy
56482	5G	$77	Buy
132113	25.00g	$158	Buy
132113	100.00g	$378	Buy
M38524	250mg	$16	Buy

Boc-o-methyl-D-serine Chemical Properties,Uses,Production

Uses

Boc-O-methyl-D-serine is used in preparation of acylamino acid heterocyclyl amides and deuterated derivatives for the treatment of BAF complex-related disorders.

Synthesis

3262-72-4

77-78-1

86123-95-7

The general procedure for the synthesis of (R)-2-tert-butoxycarbonylamino-3-methoxypropionic acid from BOC-L-serine and dimethyl sulfate was as follows: N-Boc-L-serine (22 g, 0.107 mol) was dissolved in anhydrous tetrahydrofuran (352 ml), the solution was cooled down to 0°C and the reaction mixture was stirred for 9 hours at 0-5°C. Upon completion of the reaction, the reaction was quenched by the addition of water (110 ml) and the pH was adjusted to 10-13 with 30% sodium hydroxide solution (3 ml). subsequently, the tetrahydrofuran/hexane mixture was removed by vacuum evaporation. The residue was washed with toluene (44 ml) and then acidified with 50% citric acid solution to pH < 3.5. The acidified aqueous phase was extracted with dichloromethane (2 x 91 ml, 1 x 66 ml) and the combined dichloromethane extracts were dried by azeotropic distillation. Eventually, evaporation of the solvent gave 23.7 g of product in 100% yield. The product was analyzed by HPLC showing 90.0% purity and 100% chiral purity.

References

[1] Patent: WO2006/37574, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: WO2006/37574, 2006, A1. Location in patent: Page/Page column 17-18
[3] Patent: CN104030943, 2016, B. Location in patent: Paragraph 0103; 0104
[4] Patent: WO2012/51551, 2012, A1. Location in patent: Page/Page column 36-37
[5] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395

Boc-o-methyl-D-serine Preparation Products And Raw materials

Raw materials

BOC-L-Serine (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate Methyl p-toluenesulfonate Iodomethane Dimethyl sulfate

n-Butyllithium Tetrahydrofuran Hexane

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Preparation Products

Boc-o-methyl-D-serine Suppliers

Global( 204)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1100	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
GenicBio Limited	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Sichuan Jiaying Lai Technology Co.,LTD	58
Alchem Pharmtech,Inc.	58

View Lastest Price from Boc-o-methyl-D-serine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-19	Boc-D-Ser(Me)-OH 86123-95-7	US $0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-19	Boc-D-ser(me)-OH 86123-95-7	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2025-09-25	Boc-o-methyl-D-serine 86123-95-7	US $5.00-0.10 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Boc-D-Ser(Me)-OH
86123-95-7
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-D-ser(me)-OH
86123-95-7
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Boc-o-methyl-D-serine
86123-95-7
US $5.00-0.10 / KG
99%
Henan Fengda Chemical Co., Ltd

86123-95-7(Boc-o-methyl-D-serine)Related Search:

BOC-D-TYR(BZL)-OH Boc-D-Serine Boc-O-Benzyl-D-threoninol Boc-o-methyl-D-serine DIMETHYL (BOC-AMINO)MALONATE

N-BOC-O-Benzyl-L-serine DIETHYL (BOC-AMINO)MALONATE 4-Boc-3(R)-morpholinecarboxylic acid N-(tert-Butoxycarbonyl)-O-benzyl-D-threonine BOC-D-SER(BZL)-OSU

METHYL (R)-(+)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE (R)-2,2-DIMETHYL-OXAZOLIDINE-3,4-DICARBOXYLIC ACID 3-TERT-BUTYL ESTER BOC-(2R,3R)-2-AMINO-3-ETHOXYBUTANOIC ACID 4-Methyl 2-Tert-Butyloxazolidine-3,4-Dicarboxylate Boc-D-Ser(tBu)-OH

BOC-D-THR(TBU)-OH BOC-(2R,3R)-2-AMINO-3-METHYLOXYBUTANOIC ACID BOC-D-MESER(ME)-OH

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BOC-O-METHYL-D-SERINE D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl- (9CI) 2-(tert-butoxycarbonylamino)-3-methoxypropanoic acid N-Boc-(D)-O-Methylserine O-Methyl-N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-serine D-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl- N-Boc-O-Methyl-D-serine, 98% Boc-N-D-O-methylserine (R)-2-(tert-Butoxycarbonylamino)-3-methoxypropionic acid Boc-O-Methyl-D-serine 97% (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-methoxypropanoic acid (R)-N-Boc-2-aMino-3-Methoxypropionic acid N-(tert-butoxycarbonyl)-O-methyl-D-serine Boc-D-Ser(Me)-OH 86123-95-7 Pharmaceuticalintermediates API N-BOC