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Calpain Inhibitor I

CAS No.
110044-82-1
Chemical Name:
Calpain Inhibitor I
Synonyms
ALLN;LLNL;MG 101;ac-llnl-cho;MG-101 (ALLN);InSolution? ALLN;Ac-Leu-Leu-Nle-al;AC-LL-NORLEUCINAL;CALPAIN INHIBITOR;AC-LEU-LEU-NLE-CHO
CBNumber:
CB6108214
Molecular Formula:
C20H37N3O4
Molecular Weight:
383.53
MDL Number:
MFCD00065505
MOL File:
110044-82-1.mol
Last updated:2023-05-18 11:31:10

Calpain Inhibitor I Properties

Melting point 182 °C
Boiling point 510.42°C (rough estimate)
Density 1.1322 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
form powder
pka 13.53±0.46(Predicted)
color white
Water Solubility Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
BRN 7656053
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
Safety Statements  22-24/25
WGK Germany  3
3-10
HS Code  29241900

Calpain Inhibitor I price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 208719 ALLN 110044-82-1 5mg $117 2024-03-01 Buy
Sigma-Aldrich 208719 ALLN 110044-82-1 25mg $303 2024-03-01 Buy
Sigma-Aldrich 11086090001 Calpain Inhibitor I N-Acetyl-Leu-Leu-norleucinal,synthetic 110044-82-1 25mg $343 2024-03-01 Buy
Alfa Aesar J61766 Calpain Inhibitor I, 95+% 110044-82-1 5mg $91.8 2023-06-20 Buy
Cayman Chemical 14921 Calpain Inhibitor I ≥95% 110044-82-1 1mg $31 2024-03-01 Buy
Product number Packaging Price Buy
208719 5mg $117 Buy
208719 25mg $303 Buy
11086090001 25mg $343 Buy
J61766 5mg $91.8 Buy
14921 1mg $31 Buy

Calpain Inhibitor I Chemical Properties,Uses,Production

Description

ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1?Inhibits cell cycle progression at G1/S?and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2?Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3?Blocks AIF-mediated necroptosis.4?Cell permeable.

Chemical Properties

white to off-white powder

Uses

It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Uses

Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.

Uses

Calpain inhibitor I inhibits calpain, which activates myosin light chain kinase and protein kinase C by partial proteolysis. The inhibitor should be membrane permeable due to low molecular weight and lack of charged residues.
Calpain Inhibitor I is used for western blotting methods.

Definition

ChEBI: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.

General Description

Calpain Inhibitor I is a strong, competitive inhibitor of the Ca2+-dependent neutral cysteine proteases calpain I and calpain II.

Biological Activity

Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Biochem/physiol Actions

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..

References

1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins; J. Enzyme Inhib.?3?195 2) Sherwood?et al. (1993)?In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal; Proc. Natl. Acad. Sci USA?90?3353 3) Schow and Joly (1997),?N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-kappaB activation and prevents TNF and IL-6 synthesis in vivo; Cell Immunol.?175?199 4) Shang?et al.?(2014)?Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure; BMC Neurosci.?15?63

Calpain Inhibitor I Preparation Products And Raw materials

Raw materials

Preparation Products

Calpain Inhibitor I Suppliers

Global( 115)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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Hubei Jusheng Technology Co.,Ltd.
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Amadis Chemical Company Limited
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DONBOO AMINO ACID COMPANY
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Calpain Inhibitor I Spectrum

AC-LEU-LEU-NLE-H (ALDEHYDE) AC-LEU-LEU-NORLEUCINAL AC-LL-NORLEUCINAL ac-llnl-cho Ac-Leu-Leu-Nle-al Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal Calpain Inhibitor I,96% N-Acetyl-L-leucine-L-leucine-L-norleucinal N-Acetyl-Leu-Leu-Norleu-al Calpain Inhibitor I, ALLN ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal Calpain Inhibitor Ⅰ 〔N-Acetyl-L-leucyl-L-leucyl-L-norleucinal〕 InSolution? ALLN MG-101 (ALLN) N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-Leucinamide ALLN acetylleucyl-leucyl-norleucinal N-AC-LEU-LEU-NORLEUCINAL N-ACETYL-LEU-LEU-NLE-CHO N-ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL N-ACETYL-LEU-LEU-NORLEUCINAL MG 101 LLNL CALPAIN INHIBITOR CALPAIN INHIBITOR I ACETYL-LEU-LEU-NORLEUCINAL ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL AC-LEU-LEU-L-NORLEUCINAL AC-LEU-LEU-NLE-ALDEHYDE AC-LEU-LEU-NLE-CHO CALPAIN INHIBITOR I;AC-LLNL-CHO;ALLN (S)-2-acetamido-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-4-methyl-N-((S)-1-oxohexan-2-yl)pentanamide L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]- MG-101 (Calpain inhibitor I InSolution ALLN - CAS 110044-82-1 - Calbiochem ALLN - CAS 110044-82-1 - Calbiochem CALPAIN INHIBITOR-1;MG101;MG-101;MG 101 CALPAIN INHIBITOR I RKO,MG-101,colon cancer,Bax,HepG2,Proteasome,MG 101,Inhibitor,mitochondria,HCT116,inhibit,Apoptosis,SW480,anti-tumor N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal 110044-82-1 C20H37N3O4 Enzyme Inhibitors by Type BioChemical Biochemicals and Reagents Calpain I A to C Substrate Analogs Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates inhibitor peptides ProteasomeInhibitors C-CH Cell Biology Cell Signaling and Neuroscience