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ChemicalBook >> CAS DataBase List >>2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Structure
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide structure
CAS No.
302964-24-5
Chemical Name:
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Synonyms
EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity 27;dasatinib interMediate;Dasatinib EP Impurity-A;2-AMino-N-(2-chloro-6-Meth
CBNumber:
CB61090897
Molecular Formula:
C11H10ClN3OS
Molecular Weight:
267.73
MDL Number:
MFCD10000630
MOL File:
302964-24-5.mol
Last updated:2024-04-02 14:59:00
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Properties

Melting point 208.0 to 212.0 °C
Boiling point 362.0±37.0 °C(Predicted)
Density 1.474±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Sparingly)
form powder to crystal
pka 11.09±0.70(Predicted)
color White to Light yellow
InChI InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16)
InChIKey VVOXTERFTAJMAA-UHFFFAOYSA-N
SMILES S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N
CAS DataBase Reference 302964-24-5(CAS DataBase Reference)
FDA UNII VG8Y584N6R

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
HS Code  29333990
NFPA 704
0
1 0

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A2773 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >98.0%(GC)(T) 302964-24-5 1g $41 2024-03-01 Buy
TCI Chemical A2773 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >98.0%(GC)(T) 302964-24-5 5g $62 2024-03-01 Buy
TRC A603910 2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide 302964-24-5 10g $1455 2021-12-16 Buy
American Custom Chemicals Corporation HCH0029530 2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE 95.00% 302964-24-5 1G $846.5 2021-12-16 Buy
SynQuest Laboratories 8H70-5-X5 2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 98% 302964-24-5 100g $1149 2021-12-16 Buy
Product number Packaging Price Buy
A2773 1g $41 Buy
A2773 5g $62 Buy
A603910 10g $1455 Buy
HCH0029530 1G $846.5 Buy
8H70-5-X5 100g $1149 Buy

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Chemical Properties,Uses,Production

Uses

2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib (D193600), a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs.

Synthesis

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide synthesis

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide synthesis

302964-06-3
302964-24-5
Synthesis of 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide from Dasatinib

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Preparation Products And Raw materials

Raw materials

2-Chloro-6-methylaniline N-TRIPHENYLMETHYLTHIOUREA Ethyl 2-aminothiazole-5-carboxylate Dasatinib (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
3-Ethoxyacryloyl chloride

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Preparation Products

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Suppliers

Global( 425)Suppliers
Supplier Tel Email Country ProdList Advantage
Huanfu Industrial Co.，（Shanghai）Ltd.
+86-18001856580 +86-18001856580 2415195517@qq.com China 43 58
Hebei Guanlang Biotechnology Co,.LTD 		+8619930503252 daisy@crovellbio.com China 5964 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7845 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Supplier Advantage
Huanfu Industrial Co.，（Shanghai）Ltd.
58
Hebei Guanlang Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60

View Lastest Price from 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide pictures 2024-03-29 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-24-5
 US $6.00-0.20 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-amino-N-(2-chloro-6-methyl-phenyl)thiazole-5-carboxamide pictures 2023-12-20 2-amino-N-(2-chloro-6-methyl-phenyl)thiazole-5-carboxamide
302964-24-5
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
2-Amino-N- (2-chloro-6-methylphenyl) Thiazole-5-Carboxamide pictures 2023-06-19 2-Amino-N- (2-chloro-6-methylphenyl) Thiazole-5-Carboxamide
302964-24-5
 US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD

302964-24-5(2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide)Related Search:

Dacomitinib (PF299804) Methyl 2-aminothiazole-5-carboxylate ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-5-CARBOXYLATE 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 2-Chloro-6-methylaniline
(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Dasatinib monohydrate (E)-3-Ethoxyacryloyl chloride N,N-Dimethylformamide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Dasatinib ALTRENOGEST Epichlorohydrin N-Methylformamide Glycine
N-Deshydroxyethyl Dasatinib Dasatinib Impurity 33 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

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Dasatinib IMpurity 2 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carboxiMide) 2-Amino-5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazole, 2-Amino-5-[(6-chloro-o-tolyl)carbamoyl]-1,3-thiazole 5-ThiazolecarboxaMide,2-aMino-N-(2-chloro-6-Methylphenyl) Dasatinib Int N-2 2-AMino-N-(2-chloro-6-Meth 2-AMino-N-(2-chloro-6-Methylphenyl)-5-thiazolecarboxaMide 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(Intermediate of Dasatinib) 2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carb 2-aMino-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide dasatinib interMediate 2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 98% EOS-61515 The dimer impurity Dasatinib Impurity 27 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide > 2-Amino-N-(2-chL Dasatinib Aminothiazole Impurity 2- Amino-N - (2-chloro-6-methylphenyl) thiazole-5-carboxylamide Dasatinib Impurity L 2-Amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide 2-Amino-N-(2-chloro-6-methylphenyl)thiazol-5-carboxamide 2-Amino-N - (2-chloro-6-methylphenyl) -5-thiazolamide Dasatinib EP Impurity-A 302964-24-5 392064-08-5 Dasatinib API intermediates