APILIMOD
- CAS No.
- 541550-19-0
- Chemical Name:
- APILIMOD
- Synonyms
- Apimod;Sta5326;Sta 5326;Sta-5326;APILIMOD;APILIMODUM;Apilimod, >98%;ApiliMod(STA5326);Apilimod Hydrochloride;STA 5326; STA5326; STA-5326
- CBNumber:
- CB61091430
- Molecular Formula:
- C23H26N6O2
- Molecular Weight:
- 418.49
- MDL Number:
- MFCD09954108
- MOL File:
- 541550-19-0.mol
Boiling point | 655.1±65.0 °C(Predicted) |
---|---|
Density | 1.24 |
storage temp. | -20°C |
solubility | Soluble in DMSO (>25 mg/ml) |
form | solid |
pka | 12.56±0.10(Predicted) |
color | White |
Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
FDA UNII | GFW2K84S4L |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264-P270-P301+P312-P330-P501 |
APILIMOD price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-2341 | Apilimod 99.61% | 541550-19-0 | 5mg | $50 | 2021-12-16 | Buy |
ChemScene | CS-2341 | Apilimod 99.61% | 541550-19-0 | 10mg | $80 | 2021-12-16 | Buy |
ChemScene | CS-2341 | Apilimod 99.61% | 541550-19-0 | 50mg | $120 | 2021-12-16 | Buy |
AK Scientific | SYN5487 | Apilimod | 541550-19-0 | 10mg | $156.92 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0004744 | 4'-ACETYL-BIPHENYL-4-CARBOXYLIC ACID (4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYL)-AMIDE 95.00% | 541550-19-0 | 5MG | $288.2 | 2021-12-16 | Buy |
APILIMOD Chemical Properties,Uses,Production
Description
Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level.? Suppresses Th1 but not Th2 immune response.1? Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells.? Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2? It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3? Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4
Chemical Properties
Off-White Solid
Uses
Apilimod is a small-molecule that selectively suppresses synthesis of IL-12 and IL-23. Apilimod reduces dendritic cell infiltration in psoriasis.
References
Wada et al. (2007), Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL23 inhibitor; Blood 109 1156 Cai et al. (2013), PIKfyve, a class III PI-kinase, is the target of the small molecule IL12/23 inhibitor apilimod and a new player in toll-like receptor signaling; Chem. Biol., 20 912 Gayle et al. (2016), Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma; Blood, 129 1768 Kang et al. (2020), Inhibition of PIKfyve kinase prevents infection by Zaire ebola virus and SARS-CoV-2; Proc. Natl. Acad. Sci. USA 117 20803
APILIMOD Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |