Lokelma
- CAS No.
- 17141-74-1
- Chemical Name:
- Lokelma
- Synonyms
- Lokelma;Silicic acid (H6Si3O9), sodium zirconium(4+) salt (1:2:1);1,3,5,2,4,6-trioxatrisilinane-2,2,4,4,6,6-hexaol disodium zirconium
- CBNumber:
- CB611200006
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | D652ZWF066 |
Lokelma Chemical Properties,Uses,Production
Uses
Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K+ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD)[1][2].
in vivo
Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions[2].
| Animal Model: | Sprague-Dawley rats[2] |
| Dosage: | 2, 4, and 6 g/kg |
| Administration: | Oral administration; daily, for 5 days |
| Result: | Had 99% fecal recovery in rats. Uptake and removal of potassium ions in a dose-dependent manner. |
References
[1] Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686. DOI:10.1371/journal.pone.0114686
[2] Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11. DOI:10.1038/ki.2014.382
Lokelma Preparation Products And Raw materials
Raw materials
Preparation Products
Lokelma Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8510 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Pushan Industry (Shaanxi) Co., Ltd. | 029-81310890 13571859809 | info@pushanshiye.com | China | 9953 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Baoji Didu Pharmaceutical and Chemical Co., Ltd | 029-81145305 17791533577 | 1021@dideu.com | China | 10010 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235; 18012923235 | chinasales04@tlcstandards.com.cn | China | 7972 | 58 |
| Nanjing Yikangda Pharmaceutical Technology Co.LTD | 18118984557; 18118984557 | 753016615@qq.com | China | 498 | 58 |
| Hubei Rhema Reference Materials Technology Co., Ltd. | 15787875101 | 645977340@qq.com | China | 9756 | 58 |
View Lastest Price from Lokelma manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | Sodium zirconium cyclosilicate
17141-74-1
|
US $29.00 / mg | 95.00% | 10g | TargetMol Chemicals Inc. |
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- Sodium zirconium cyclosilicate
17141-74-1
- US $29.00 / mg
- 95.00%
- TargetMol Chemicals Inc.
