Darunavir-D9
- CAS No.
- 1133378-37-6
- Chemical Name:
- Darunavir-D9
- Synonyms
- TMC-114-d9;UIC-94017-d9;Darunavir-D9;[2H9]-Darunavir;Nebramine Impurity 2;Darunavir-d9;Darunavir-d9 (iso-butyl-d9);[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl-d9)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester;[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl-d9)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-β]-furan-3-yl Ester;Darunavir D9Q: What is Darunavir D9 Q: What is the CAS Number of Darunavir D9 Q: What is the storage condition of Darunavir D9 Q: What are the applications of Darunavir D9
- CBNumber:
- CB61121362
- Molecular Formula:
- C27H37N3O7S
- Molecular Weight:
- 547.66358
- MDL Number:
- MFCD09840303
- MOL File:
- 1133378-37-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Darunavir-D9 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25220 | Darunavir-d9 ≥99% deuterated forms (d1-d9) | 1133378-37-6 | 1mg | $517 | 2024-03-01 | Buy |
| Usbiological | D1078-05 | Darunavir-d9 | 1133378-37-6 | 1mg | $566 | 2021-12-16 | Buy |
| TRC | D193502 | Darunavir-d9 | 1133378-37-6 | 10mg | $2180 | 2021-12-16 | Buy |
| TRC | D193502 | Darunavir-d9 | 1133378-37-6 | 1mg | $275 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BAR0001577 | DARUNAVIR-D9 95.00% | 1133378-37-6 | 10MG | $2656.5 | 2021-12-16 | Buy |
Darunavir-D9 Chemical Properties,Uses,Production
Description
Darunavir-d9 is intended for use as an internal standard for the quantification of darunavir (Item Nos. 15866 | 31083) by GC- or LC-MS. Darunavir is an HIV-1 protease inhibitor. It is active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) with a cytotoxic concentration (CC50) of 74.4 μM. Darunavir is also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells (PHA-PBMCs; IC50s = 3 and 3-29 nM, respectively). It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively). Formulations containing darunavir have been used in combination therapy for the treatment of HIV.
Chemical Properties
Off-White Amorphous Solid
Uses
Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
Uses
Darunavir-D9 can be intended for use as an internal standard for the quantification of Darunavir by GC- or LC-mass spectrometry.
Uses
Darunavir-D9 can be used as second generation HIV-1-protease inhibitor; structurally similar to amprenavir.
Darunavir-D9 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9240 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Clearsynth Canada Inc. | +1.415.685.4395 | enquiry@clearsynth.com | Canada | 912 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9506 | 60 |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3021 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2076 | 58 |
| Hubei Moco Chemical Co., Ltd. | 18627756402 | 3001051413@qq.com | China | 10008 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | rose.shi@synzest.com | China | 9287 | 58 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 15347293736 | 2853117764@qq.com | China | 8903 | 58 |