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Mexiletine hydrochloride

Mexiletine hydrochloride
Mexiletine hydrochloride structure
CAS No.
5370-01-4
Chemical Name:
Mexiletine hydrochloride
Synonyms
Toy;Katen;ko1173;Olzoron;mexitil;Ritalmex;Ko 1173Cl;Mexilitene;Cirumimeru;MEXILITINE HCL
CBNumber:
CB6114224
Molecular Formula:
C11H18ClNO
Formula Weight:
215.72
MOL File:
5370-01-4.mol

Mexiletine hydrochloride Properties

Melting point:
200-203°C
storage temp. 
2-8°C
solubility 
ethanol: 50 mg/mL
pka
9.0(at 25℃)
form 
powder
color 
white
λmax
272nm(MeOH)(lit.)
Merck 
14,6169
CAS DataBase Reference
5370-01-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  36-26
WGK Germany  3
RTECS  KR9300000
Toxicity LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:

Mexiletine hydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 462047 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride 97% 5370-01-4 1g $28.2 2018-11-13 Buy
Sigma-Aldrich 1443250 Mexiletine hydrochloride United States Pharmacopeia (USP) Reference Standard 5370-01-4 200mg $348 2018-11-13 Buy
TCI Chemical M2040 Mexiletine Hydrochloride >98.0%(HPLC)(N) 5370-01-4 1g $33 2018-11-22 Buy
TCI Chemical M2040 Mexiletine Hydrochloride >98.0%(HPLC)(N) 5370-01-4 5g $90 2018-11-22 Buy
Cayman Chemical 23782 Mexiletine (hydrochloride) ≥98% 5370-01-4 10g $48 2018-11-19 Buy

Mexiletine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

Antiarrhythmic (class IB)

Uses

antipsychotic

Definition

ChEBI: A hydrochloride composed of equimolar amounts of mexiletine and hydrogen chloride.

brand name

Mexitil (Boehringer Ingelheim).

General Description

Mexiletine hydrochloride,1-methyl-2-(2,6-xylyloxy)ethylamine hydrochloride (Mexitil)(pKa 8.4), is a class IB antiarrhythmic agent that is effectivewhen given either intravenously or orally. It resembles lidocainein possessing a xylyl moiety but otherwise is differentchemically. Mexiletine hydrochloride is an ether and is notsubject to the hydrolysis common to the amides lidocaineand tocainide. Its mean half-life on oral administration isapproximately 10 hours.
Although not subject to hydrolysis, mexiletine hydrochlorideis metabolized by oxidative and reductiveprocesses in the liver. Its metabolites, p-hydroxymexiletineand hydroxymethylmexiletine, are not pharmacologicallyactive as antiarrhythmic agents.

Biological Activity

Use-dependent sodium channel blocker (IC 50 values are 75.3 and 23.6 μ M for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Clinical Use

Mexiletine hydrochloride, like class I antiarrhythmicagents, blocks the fast Na channel in cardiac cells. It isespecially effective on the Purkinje fibers in the heart. Thedrug increases the threshold of excitability of myocardialcells by reducing the rate of rise and amplitude of the actionpotential and decreases automaticity.
Mexiletine hydrochloride is used for long-term oral prophylaxisof ventricular tachycardia. The drug is given in200- to 400-mg doses every 8 hours.

Mexiletine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Mexiletine hydrochloride Suppliers

Global( 149)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
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0755-23311925 Abel@chembj.com CHINA 3203 55
Mainchem Co., Ltd.
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Xiamen AmoyChem Co., Ltd
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Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2214 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40277 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15884 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24560 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44046 61

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