Lisinopril
- CAS No.
- 76547-98-3
- Chemical Name:
- Lisinopril
- Synonyms
- mk522;CORIC;PRINIL;MK-521;Tensyn;Longes;Cipral;Linvas;mk0521;CARACE
- CBNumber:
- CB6117715
- Molecular Formula:
- C21H31N3O5
- Molecular Weight:
- 405.49
- MDL Number:
- MFCD00214086
- MOL File:
- 76547-98-3.mol
Melting point | 162-165 °C |
---|---|
Boiling point | 666.4±55.0 °C(Predicted) |
Density | 1.251±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: ≥10 mg/mL |
pka | 2.18±0.10(Predicted) |
form | solid |
color | white |
BCS Class | 3 |
CAS DataBase Reference | 76547-98-3(CAS DataBase Reference) |
FDA UNII | 7Q3P4BS2FD |
NCI Dictionary of Cancer Terms | Prinivil; Zestril |
NCI Drug Dictionary | Prinivil |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
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Signal word | Warning | |||||||||
Hazard statements | H361-H373 | |||||||||
Precautionary statements | P201-P202-P260-P280-P308+P313-P405-P501 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TW3589990 | |||||||||
NFPA 704 |
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Lisinopril price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 16833 | Lisinopril ≥98% | 76547-98-3 | 1g | $70 | 2024-03-01 | Buy |
Cayman Chemical | 16833 | Lisinopril ≥98% | 76547-98-3 | 5g | $299 | 2024-03-01 | Buy |
Cayman Chemical | 16833 | Lisinopril ≥98% | 76547-98-3 | 100mg | $11 | 2024-03-01 | Buy |
Cayman Chemical | 16833 | Lisinopril ≥98% | 76547-98-3 | 500mg | $40 | 2024-03-01 | Buy |
Activate Scientific | AS112353 | Lisinopril 96% | 76547-98-3 | 5G | $342 | 2021-12-16 | Buy |
Lisinopril Chemical Properties,Uses,Production
Description
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM). It reduces the formation of endothelin-1 and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM. Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 μg/kg, respectively).
Originator
Acebitor 5,Biddle Sawyer,India
Uses
Labeled Lisinopril, intended for use as an internal standard for the quantification fo Lisinopril by GC- or LC-mass spectrometry.
Uses
Lisinopril is an antihypertensive medication.
Definition
ChEBI: Lisinopril is a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a L-prolino group and a L-lysine residue.
Manufacturing Process
2-Oxo-4-phenylbutyric acid and t-BOC-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. Essentially all of the t-BOC protecting group is cleaved when the product is absorbed on strong acid ion exchange resin. The crude N-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline is eluted from the resin with 10% ammonia, freeze dried, and purified by gel filtration chromatography (LH-20). A minute peak for t-BOC protons in the NMR spectrum disappears when the product is treated with ethyl acetate that is 4 N in hydrogen chloride gas. The NMR spectrum of the resulting HCl salt of the product is consistent with structure. The mass spectrum shows a molecular ion at 693 m/e for the tetrasilylated species. Chromatography on XAD-2 resin using 3.5% acetonitrile in 0.1 molar ammonium hydroxide affords N-α-((1S)- 1-carboxy-3-phenylpropyl)-L-lysyl-L-proline. The last peptide can be produced if 2-oxo-4-phenylbutyric acid and N-t-Boc-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. The product is absorbed on strong acid ion exchange resin, and eluted with 2% pyridine in water. Product-rich cuts are stripped to a glass and treated with 4 N HCl in ethylacetate to remove the t-Boc protecting group. The resulting hydrochloride salt is converted to the free base by absorbing on strong acid ion exchange resin and eluting with 2% pyridine in water. Freeze drying of product-rich cuts affords N-α-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline as a white fluffy solid. The NMR spectrum is consistent with structure. The mass spectrum shows a molecular ion at 549 for the disilylated species. Chromatography affords the desired isomer.
brand name
Prinivil (Merck); Zestril (AstraZeneca).
Therapeutic Function
Antihypertensive
Lisinopril Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7930 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15394 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9316 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 905 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 |
View Lastest Price from Lisinopril manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-13 | Lisinopril
76547-98-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-10 | Lisinopril
76547-98-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-06 | Lisinopril
76547-98-3
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- Lisinopril
76547-98-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Lisinopril
76547-98-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Lisinopril
76547-98-3
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
76547-98-3(Lisinopril)Related Search:
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