ChemicalBook >> CAS DataBase List >>INDEX NAME NOT YET ASSIGNED
INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2803699-72-9
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- 113-O12B
- CBNumber:
- CB612037122
- Molecular Formula:
- C57H111N3O8S8
- Molecular Weight:
- 1223.01
- MDL Number:
- MOL File:
- 2803699-72-9.mol
Last updated:2023-05-21 10:59:17
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Biological Activity
113-O12B is a disulfide bond-containing ionizable cationic lipidoid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8+ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model.
References
1.Chen, J., Ye, Z., Huang, C., et al.Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell responseProc. Natl. Acad. Sci. USA119(34)e2207841119(2022)
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
Global( 5)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Changyu Medical Technology Co. Ltd. | +86-13301875428 | sales@changyuhe.com | China | 292 | 58 |
Shochem(Shanghai)Co.,Ltd | +86-021-51783479 +86-13816874662 | info@shochem.com | China | 295 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
Shochem (Shanghai) Co.,Ltd | 13611745246 13816874662 | sales@shochem.com | China | 435 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 40885 | 58 |
113-O12B
2803699-72-9
C57H111N3O8S8