ChemicalBook >> CAS DataBase List >>Irinotecan hydrochloride trihydrate
Irinotecan hydrochloride trihydrate
- CAS No.
- 136572-09-3
- Chemical Name:
- Irinotecan hydrochloride trihydrate
- Synonyms
- Iriontecan HCL;Irinotecan HCL 3H2O;Irinotecan HydrochL;Irinotecan Trihydrate;CPT-11 HCl Trihydrate;Irinotecan Hydrochlorid;IRINOTECON HCL TRIHYDRATE;IRINOTECAN HCL TRIHYDRATE;Irinotecan HCI Trihydrate;trihydrate,(s)-hydrochlorid
- CBNumber:
- CB6122430
- Molecular Formula:
- C33H45ClN4O9
- Molecular Weight:
- 677.18
- MDL Number:
- MFCD01765731
- MOL File:
- 136572-09-3.mol
Last updated:2023-09-11 17:45:53
| Melting point | 250-256°C (dec.) |
|---|---|
| Boiling point | 257°C(lit.) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml). |
| form | White solid. |
| color | Yellow |
| Water Solubility | Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming |
| Merck | 14,5091 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 136572-09-3(CAS DataBase Reference) |
| FDA UNII | 042LAQ1IIS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H372 | |||||||||
| Precautionary statements | P260-P264b-P270-P301+P312-P314-P330-P403-P501c | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 20/21-22 | |||||||||
| RTECS | DW1060750 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |||||||||
| NFPA 704 |
|
Irinotecan hydrochloride trihydrate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1347609 | Irinotecan hydrochloride United States Pharmacopeia (USP) Reference Standard | 136572-09-3 | 100MG | $698 | 2024-03-01 | Buy |
| TCI Chemical | I0714 | Irinotecan Hydrochloride Trihydrate >98.0%(HPLC)(T) | 136572-09-3 | 100mg | $84 | 2024-03-01 | Buy |
| Alfa Aesar | J62370 | Irinotecan hydrochloride trihydrate 99% | 136572-09-3 | 100mg | $172.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62370 | Irinotecan hydrochloride trihydrate 99% | 136572-09-3 | 250mg | $337.65 | 2024-03-01 | Buy |
| Cayman Chemical | 14180 | Irinotecan (hydrochloride hydrate) | 136572-09-3 | 100mg | $96 | 2024-03-01 | Buy |
Irinotecan hydrochloride trihydrate Chemical Properties,Uses,Production
Description
Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
Chemical Properties
White powder
Uses
Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
Definition
ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
brand name
Camptosar (Pharmacia &Upjohn) .
Hazard
Moderately toxic by ingestion.
References
1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert
Irinotecan hydrochloride trihydrate Preparation Products And Raw materials
Global( 473)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hainan Xiyuan Chemical Technology Co., Ltd. | +86-15008981366 | 15008981366@163.com | CHINA | 9 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from Irinotecan hydrochloride trihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-11 | Irinotecan hydrochloride trihydrate
136572-09-3
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-08-23 | Irinotecan hydrochloride trihydrate
136572-09-3
|
US $20.00 / kg | 1kg | 99% | 5000 Ton | Hebei Duling International Trade Co. LTD | |
 |
2021-11-02 | Irinotecan hydrochloride trihydrate
136572-09-3
|
US $10.00 / Kg/Bag | 1KG | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- Irinotecan hydrochloride trihydrate
136572-09-3
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Irinotecan hydrochloride trihydrate
136572-09-3
- US $20.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Irinotecan hydrochloride trihydrate
136572-09-3
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
136572-09-3(Irinotecan hydrochloride trihydrate)Related Search:
Irinotecan-d10 hydrochloride trihydrate
CPT-11 HCl Trihydrate
irinotecan hydrochloride hydrate
Irinotecanhydrochloridetrihydrate(CPT-11)
IRINOTECON HCL TRIHYDRATE
[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE
(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%
Irinotecan Hydrochloride (100 mg)
Irinotecan Hydrochloride
Irinotecan Trihydrate
[1,4'-Bipiperidine]-1'-carboxylicacid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-ylester,hydrochloride,hydrate(1:1:3)
Irinotecan HCl Trihydrate (CaMpto)
Irinotecan, Hydrochloride Salt, Trihydrate
Irinotecan hydrochloride trihydrate, >=99%
(1,4’-bipiperidine)-1’-carboxylicacid,4,11-diethyl-3,4,12,14-tetrahydro-4-hyd
roxy-3,14-dioxo-1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinolin-9-ylester,mono
trihydrate,(s)-hydrochlorid
IRINOTECAN HYDROCHLORIDE TRIHYDRATE
IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE
IRINOTECAN HCL TRIHYDRATE
Irinotecan HCL 3H2O
rinotecan hydrochloride trihydrate
(s)-[1,4'-bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
Irinotecan Hydrochlorid
7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate CRS
Irinotecan for peak identification
Irinotican Hydrochloride Trihydrate
IrinotecanHydrochlorideTrihydrate>
Irinotecan HydrochL
Irincan hydrochloride trihydrate
Irinotecan hydrochloride trihydrate USP/EP/BP
Irinotican Hydrochloride TrihydrateQ: What is
Irinotican Hydrochloride Trihydrate Q: What is the CAS Number of
Irinotican Hydrochloride Trihydrate Q: What is the storage condition of
Irinotican Hydrochloride Trihydrate Q: What are the applications of
Irinotican Hydrochloride Trihydrate
Irinotecan for peak identification (Y0001831)
Irinotecan for system suitability 1 (Y0001830)
Irinotecan for system suitability 2 (Y0001833)
Irinotecan Hydrochloride (1347609)
Irinotecan hydrochloride trihydrate (Y0001832)
Iriontecan HCL
CPT 11; CAMPTOSAR; CAMPTO; IRINOTECAN
Irinotecan HCI Trihydrate
(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
Irinotecan hydrochloride trihydrate 98%
(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate
Irinotecan (CPT-11) HCl Trihydrate
136572-09-3
6572-09-3
36572-09-3
C33H38N4O6HCl3H2O
C33H38N4O6ClH3H2O
C33H45ClN4O9
Inhibitors
Anticancer
Anti-cancer&immunity
API