2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

Uses

3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson''s disease.

Uses

3-Hydroxykynurenine is a metabolite of tryptophan. ential endogenous neurotoxin.

Uses

3-Hydroxy-DL-kynurenine has been used:

• as a substrate for the recombinant human kynureninase assay
• as a reference standard in tandem mass spectrometry (MS/MS) analysis
• as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients

Definition

ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.

General Description

3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.

Biochem/physiol Actions

3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.