3,5-dihydroxy-3-methyl-Pentanoic acid
- CAS No.
- 150-97-0
- Chemical Name:
- 3,5-dihydroxy-3-methyl-Pentanoic acid
- Synonyms
- MVS;MK 91;(±)-MVA-Li;rac.-MVA-Li;Hiochic Acid;Mevalonic acid;RS-Mevalonic Acid;D,L-Mevalonic Acid;Tedizolid Impurity 85;(RS)-Mevalonic acid lithium salt
- CBNumber:
- CB61236091
- Molecular Formula:
- C6H12O4
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD00870420
- MOL File:
- 150-97-0.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | Soluble in DMSO |
| Boiling point | 364.1±32.0 °C(Predicted) |
| Density | 1.263±0.06 g/cm3(Predicted) |
| Melting point | 151-152 °C(Solv: benzene (71-43-2)) |
| pka | 4.33±0.10(Predicted) |
| Concentration | 0.1 mCi/ml |
| Specific Activity | 10-20 Ci/mmol |
| Solvent | Ethanol:0.15N NH4OH (1:1) |
| FDA UNII | S5UOB36OCZ |
| EPA Substance Registry System | Pentanoic acid, 3,5-dihydroxy-3-methyl- (150-97-0) |
3,5-dihydroxy-3-methyl-Pentanoic acid price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 90469 | (RS)-Mevalonic acid lithium salt ≥96.0% (GC) | 150-97-0 | 10mg | $193 | 2024-03-01 | Buy |
| Sigma-Aldrich | 42147 | (RS)-Mevalonic acid lithium salt analytical reference material | 150-97-0 | 5mg | $122 | 2024-03-01 | Buy |
| Sigma-Aldrich | 90469 | (RS)-Mevalonic acid lithium salt ≥96.0% (GC) | 150-97-0 | 50mg | $619 | 2024-03-01 | Buy |
| Sigma-Aldrich | 90469 | (RS)-Mevalonic acid lithium salt ≥96.0% (GC) | 150-97-0 | 250mg | $2760 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | BRS0000278 | DL-MEVALONIC ACID 95.00% | 150-97-0 | 50MG | $715.52 | 2021-12-16 | Buy |
3,5-dihydroxy-3-methyl-Pentanoic acid Chemical Properties,Uses,Production
Uses
Precursor in the biosynthesis of cholesterol. Occurs in equilibrium with the d-lactone
Definition
Anorganic acid, it is an intermediate in the biosyn-thesis of squalene, cholesterol, and coenzyme q inplants and animals.
Biosynthesis
Mevalonic acid is the primary precursor of an the terpenoids and steroids biosynthesised by plants. It is derived from acetyl CoA through the intermediate formation of acetoacetyl CoA and 3-hydroxy-3-methylglutaryl CoA (HMG CoA), these reactions being catalysed by acetyl CoA acetyltransferase and HMG CoA synthase, respectively. Reduction of HMG CoA, catalysed by HMG CoA reductase, gives mevalonic acid.
Before the pathway can continue, mevalonic acid must be catalytically phosphorylated by ATP and mevalonic acid kinase. Mevalonic acid kinase activity has been detected in many plants and has been found to be inhibited by such products of the acetate-mevalonate pathway as geranyl, farnesyl, geranylgeranyl and phytyl pyrophosphates. Thus, phosphorylation of mevalonic acid is a primary point at which control of terpenoid and steroid biosynthesis operates. Phosphorylation leads first to the mono- and then to the pyrophosphate. The second phosphorylation is catalysed by phosphomevalonate kinase.
Biochem/physiol Actions
Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
3,5-dihydroxy-3-methyl-Pentanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-dihydroxy-3-methyl-Pentanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15878 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Beijing OKA biological technology co., LTD | 010-62971590 18548936886 | 3462612863@qq.com | China | 6912 | 58 |
| Guangdong wengjiang Chemical Reagent Co., Ltd. | 0751-2815688 13927872512 | 3007421951@qq.com | China | 10084 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27996 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb5@aikonchem.com | China | 10529 | 58 |