NADA
- CAS No.
- 199875-69-9
- Chemical Name:
- NADA
- Synonyms
- NADA;AA-DA;ARACHIDONOYLDOPAMIDE;Arachidonyl dopamine;N-arachidonyldopamine;ARACHIDONOYL DOPAMINE;N-ARACHIDONOYLDOPAMINE;NADA (Arachidonoyl dopamine);N-Arachidonoyl Dopamine (NADA);N-ARACHIDONOYL-3-HYDROXYTYRAMINE
- CBNumber:
- CB6127354
- Molecular Formula:
- C28H41NO3
- Molecular Weight:
- 439.63
- MDL Number:
- MFCD03412031
- MOL File:
- 199875-69-9.mol
| Boiling point | 640.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.023±0.06 g/cm3(Predicted) |
| Flash point | 14 °C |
| storage temp. | −20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| pka | 9.79±0.10(Predicted) |
| form | ethanol solution |
| color | Pale yellow |
| Sensitive | Air Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month. |
| FDA UNII | Q8NX2KL2YP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/37/38 | |||||||||
| Safety Statements | 16-26-36 | |||||||||
| RIDADR | UN 1170 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
NADA price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67250 | N-Arachidonoyldopamine, 98% | 199875-69-9 | 5mg | $91.6 | 2021-12-16 | Buy |
| Alfa Aesar | J67250 | N-Arachidonoyldopamine, 98% | 199875-69-9 | 25mg | $339 | 2021-12-16 | Buy |
| Cayman Chemical | 90057 | N-Arachidonoyl Dopamine ≥98% | 199875-69-9 | 5mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 90057 | N-Arachidonoyl Dopamine ≥98% | 199875-69-9 | 10mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 90057 | N-Arachidonoyl Dopamine ≥98% | 199875-69-9 | 50mg | $410 | 2024-03-01 | Buy |
NADA Chemical Properties,Uses,Production
Description
N-Arachidonoyldopamine (199875-69-9) is an endogenous conjugate of arachidonic acid and dopamine.1?May be the “endogenous capsaicin like substance” in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 μM for CB1 and CB2 respectively)2?and results in a distinct signaling profile from any known cannabinoid3. Competitive inhibitor of FAAH and anandamide transport.4. Modulates acute systemic inflammation via non-hematopoietic TRPV1.5
Uses
NADA is a endogenous CB1 agonist, as well as a vanilloid agonist and inhibitor of FAAH and AMT.
Definition
ChEBI: Arachidonoyl dopamine is a fatty amide, a member of catechols, a secondary carboxamide and a N-(fatty acyl)-dopamine. It is functionally related to a dopamine and an arachidonic acid.
Biological Activity
Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB 1 over CB 2 receptors (K i values are 0.25 and 12 μ M respectively), and potent agonist at TRPV1 (VR1) receptors (EC 50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo . Also available as part of the Endocannabinoid Tocriset™ .
References
1) Huang?et al.?(2002),?An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors; Proc. Natl. Acad. Sci. USA,?99?8400 2) Bisogno?et al.?(2000),?N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo; Biochem. J.,?351 Pt 3?817 3) Redmund?et al.?(2016),?Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors; Br. J. Pharmacol.,?173?115 4) Petrocellis?et al.?(2000),?Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity; FEBS Lett.,?483?52 5) Lawton?et al.?(2017),?N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1; J. Immunol.,?199?1465
NADA Preparation Products And Raw materials
Raw materials
Preparation Products
NADA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9374 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9288 | 58 |