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Amprolium

Amprolium structure

CAS No.: 121-25-5

Chemical Name:: Amprolium

Synonyms: AMPROLIUM;Amprolium HCI;AMproliuM, USP;Amprolium [INN:BAN];Amprolium USP/EP/BP;AMPROLIUM USP 26, BPV 98;Venlafaxine Impurity 1-d6;amprolium/amprolium hydrochloride;(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.;1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride

CBNumber:: CB6127743

Molecular Formula:: C14H19N4.Cl

Molecular Weight:: 278.79

MDL Number:: MFCD00072061

MOL File:: 121-25-5.mol

Last updated:2023-12-13 14:53:42

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Amprolium Properties

Melting point	246-248 °C (decomp)
storage temp.	0-6°C
solubility	Soluble in DMSO
color	Crystals from methanol + ethanol
Stability	Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
InChI	InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
InChIKey	LCTXBFGHZLGBNU-UHFFFAOYSA-M
SMILES	C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
CAS DataBase Reference	121-25-5(CAS DataBase Reference)
FDA 21 CFR	556.50; 558.55
FDA UNII	71M75T660B
EPA Substance Registry System	Amprolium (121-25-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Amprolium price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2345	Amprolium Pharmaceutical Secondary Standard; Certified Reference Material	121-25-5	500MG	$200	2024-03-01	Buy
TRC	A634413	Amprolium	121-25-5	2.5mg	$45	2021-12-16	Buy
TRC	A634413	Amprolium	121-25-5	5mg	$60	2021-12-16	Buy
Medical Isotopes, Inc.	18478	Amprolium	121-25-5	25mg	$1500	2021-12-16	Buy
Crysdot	CD31004266	Amprolium 98+%	121-25-5	100mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR2345	500MG	$200	Buy
A634413	2.5mg	$45	Buy
A634413	5mg	$60	Buy
18478	25mg	$1500	Buy
CD31004266	100mg	$50	Buy

Amprolium Chemical Properties,Uses,Production

Description

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Chemical Properties

solid

Originator

Neoprol ,SIMB

Uses

Coccidiostat (for poultry).

Uses

Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.

Definition

ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.

Manufacturing Process

1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).

brand name

Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).

Therapeutic Function

Coccidiostatic

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Side effects

Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.

Safety Profile

When heated to decomposition emits toxic fumes of Cl-.

Amprolium Preparation Products And Raw materials

Raw materials

Hydrochloric acid Tosyl chloride 2-Picoline

Preparation Products

Amprolium Suppliers

Global( 175)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12452	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

Supplier	Advantage
shandong perfect biotechnology co.ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Amprolium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-12	amprolium hydrochloride 121-25-5	US $0.00 / KG	1KG	98% HPLC	5 ton	shandong perfect biotechnology co.ltd
2023-08-31	Amprolium 121-25-5	US $100.00 / bag	1bag	99	5000	Hebei Fengqiang Trading Co., LTD
2023-06-20	Amprolium 121-25-5	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

amprolium hydrochloride
121-25-5
US $0.00 / KG
98% HPLC
shandong perfect biotechnology co.ltd

Amprolium
121-25-5
US $100.00 / bag
99
Hebei Fengqiang Trading Co., LTD

Amprolium
121-25-5
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

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1of4

AMPROLIUM 1-[[4-Amino-2-propyl-5-pyrimidinyl] methyl]-2-picolinium chloride hydrochloride 1-[2-Propyl-4-amino-5-pyrimidylmethyl]-2-methylpyridinium chloride hydrochloride Pyridinium, 1-(4-amino-2-propyl-5-pyrimidinyl)methyl-2-methyl-, chloride AMPROLIUM USP 26, BPV 98 (1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID. 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride Amprolium [INN:BAN] AMproliuM, USP [5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-yl]amine chloride 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine chloride 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride (1R,2S,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydronaphthalene-1,2-diol Amprolium USP/EP/BP 1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride amprolium/amprolium hydrochloride Venlafaxine Impurity 1-d6 Amprolium HCI 121-25-5 C14H19CIN4HCl C14H19ClN4 APIs API's