ChemicalBook >> CAS DataBase List >>1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2)

1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2)

1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) structure

CAS No.: 2322264-11-7

Chemical Name:: 1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2)

Synonyms: Ilaprazole sodium hydrate;1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2)

CBNumber:: CB612863695

Molecular Formula:: C19H21N4NaO3S

Molecular Weight:: 408.45

MDL Number:

MOL File:: 2322264-11-7.mol

Last updated:2025-07-17 18:53:03

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1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) Properties

form	Solid
color	White to light yellow

1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) Chemical Properties,Uses,Production

Uses

Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2].

in vivo

Ilaprazole sodium hydrate (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion^[1].
In anesthetized rats, Ilaprazole sodium hydrate dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v. injection, the ED₅₀ of Ilaprazole sodium hydrate and Omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED₅₀ of Ilaprazole sodium hydrate and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole sodium hydrate also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED₅₀ is 2.1 mg/kg and that of Omeprazole is 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole sodium hydrate is equipotent to Omeprazole. Ilaprazole sodium hydrate also inhibits gastric acid secretion strongly in fistular rats. The ED₅₀ of Ilaprazole sodium hydrate administered intraduodenally is 0.43 mg/kg and that of Omeprazole Is 0.68 mg/kg^[1].

Animal Model:	Male SD rat (after pylorus ligation)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Intraduodenally
Result:	The acid output and volume significantly inhibited by about 60% and 46% at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93% and 73% inhibition on acid output and volume, respectively.

References

[1] Kwon D, et al. Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo. Arzneimittelforschung. 2001;51(3):204-213. DOI:10.1055/s-0031-1300026
[2] Zheng M, et al. Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase. Oncotarget. 2017;8(24):39143-39153. DOI:10.18632/oncotarget.16609

1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32376	58
Shanghai Hanhong Scientific Co., Ltd.	+undefined17612118332	Lucky@hanhonggroup.com	China	6035	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 18100677375	sales@szzxbio.com	China	2994	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	26070	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Hanhong Scientific Co., Ltd.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from 1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-17	Ilaprazole sodium hydrate 2322264-11-7	US $49.00 / mg		99.2%	10g	TargetMol Chemicals Inc.

Ilaprazole sodium hydrate
2322264-11-7
US $49.00 / mg
99.2%
TargetMol Chemicals Inc.

1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-, sodium salt, hydrate (1:1:2) Ilaprazole sodium hydrate 2322264-11-7