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Artificial flavor Chemical properties Content analysis Toxicity Toxicity Usage limit Standard for Maximum Allowable Amount Chemical properties Application Preparation Category Toxic classification Acute toxicity Flammability and Hazardous characteristics Storage and transportation characteristics Extinguishing agent
Carvacrol structure
Chemical Name:
Cymenol;Oxycymol;o-Thymol;ISOTHYMOL;CARVACROL;FEMA 2245;Antioxine;Karvakrol;-2-methyL;CYMOPHENOL
Molecular Formula:
Formula Weight:
MOL File:

Carvacrol Properties

Melting point:
3-4 °C(lit.)
Boiling point:
236-237 °C(lit.)
0.976 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.522(lit.)
Flash point:
224 °F
storage temp. 
Water Solubility 
JECFA Number
Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference
499-75-2(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
EWG's Food Scores
NIST Chemistry Reference
Phenol, 2-methyl-5-(1-methylethyl)-(499-75-2)
EPA Substance Registry System
Isopropyl-o-cresol (499-75-2)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H319-H302-H315-H318
Precautionary statements  P264-P270-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P280-P301+P312+P330-P305+P351+P338+P310
Hazard Codes  C
Risk Statements  22-34
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 3
WGK Germany  3
RTECS  FI1225000
HazardClass  8
PackingGroup  III
HS Code  29071990
Toxicity LD orally in rabbits: 100 mg/kg (Kochmann)

Carvacrol price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 282197 Carvacrol 98% 499-75-2 10g $54.3 2021-03-22 Buy
Sigma-Aldrich W224511 Carvacrol natural, 99%, FG 499-75-2 100 g $61 2021-03-22 Buy
Sigma-Aldrich W224502 Carvacrol ≥98%, FCC, FG 499-75-2 100 g $70 2021-03-22 Buy
Sigma-Aldrich 8.20258 5-Isopropyl-2-methylphenol for synthesis 499-75-2 50 mL $97.12 2021-03-22 Buy
Sigma-Aldrich W224502 Carvacrol ≥98%, FCC, FG 499-75-2 1 kg $137 2021-03-22 Buy

Carvacrol Chemical Properties,Uses,Production

Artificial flavor

Carvacrol is the isomeric body of thymol with similar aroma as thymol. Carvacrol naturally exists in thyme oil and other essential oils, having especially high content in the thyme oil produced in Spain.
Carvacrol is mainly used in the preparation of dill, girofle, mint and vanilla flavor to be used for toothpaste, toothpaste powder, oral products, talcum powder, soap and daily industrial products. In medicine, it is used for local anesthetics. In addition, carvacrol is capable of killing bacteria and intestinal parasites and can be used as disinfectants and fungicides. According to the information reported, the acute toxicity data of carvacrol: oral LD50810mg/kg (rat), skin test: LD50> 5g/kg (rabbit).
Thyme plant has its origin including the Northeast, Hebei, and Inner Mongolia, Gansu, Qinghai and Xinjiang and other provinces. Ingredients: whole plant of thyme contains about 0.15~0.5% volatile oil (in oil, the component mainly contains carvacrol, paraffin, thymol), amaroid and tannin. Leaves contain free oleanolic acid, ursolic acid, caffeic acid and so on. Thyme can be not only used in medicine, for spices, but also be as the superior natural health ingredients of the processed foods. Since the 1980s, thyme-like herbal foods have become very popular. Studies have shown that thyme-containing volatile oils, in addition to being used as seasoning and for treatment of illnesses, also have anti-corrosion, antibacterial and other functions. Therefore, the consumers can benefit a lot using it as food raw materials. Because of this, in Europe, natural herbal tea also contains thyme. For example, a kind of herb tea raw material having anti-cough effect and being able to prevent and treat bronchitis has 10% thyme leaves.
thymus plant
Image 1: Thymus plant

Chemical properties

Use sulfuric acid to sulfonate the p-isopropyl toluene, generating p-isopropyl toluene-2-sulfonic acid. Then we can obtain carvacrol after alkali melting treatment.
preparation of carvacrol
Image 2: Preparation of carvacrol from p-isopropyltoluene
Carvacrol, when co-melted together with potassium hydroxide, can give 2-hydroxy-4-isopropyl benzoic acid while reaction with phosphorus pentachloride can generate 2-chloro-1-methyl-4-isopropyl benzene. In acetic acid, it reaction with 1 mol Bromine can generate 4-bromocarbinol while its reaction with 2 mol bromine can generate 4, 6-dibromo carvacrol; if reacted with bromine and aluminum, we can obtain tetrabromo-o-cresol. It is easily soluble in concentrated sulfuric acid to produce 2-methyl-5-isopropyl phenol-4-sulfonic acid. In aqueous sodium hydroxide solution, it can be reacted with formaldehyde to generate carvacrol phenols alcohol:
generation of carvacrol phenolic alcohol
Image 3: The reaction between carvacrol and formaldehyde for generation of carvacrol phenolic alcohol
It exhibits green color when reacted with ferric chloride in ethanol with no significant color in the water.

Content analysis

It can be determined by the non-polar column method by GT-10-4.


LD50: 810 mg/kg (rat, oral).


LD50: 810 mg/kg (rat, oral).

Usage limit

FEMA (mg/kg): soft drinks 26; cold drinks 34; candy 92; baked goods 120; condiments 37.
Take appropriate as limit (FDA § 172.515, 2000).
Allow to use (GB 2760-1996).

Standard for Maximum Allowable Amount

Name of additive
Field allowed to use it as additive
Function of additive
Maximal allowable amount(g/kg)
Food spices
The perfume ingredients used in formulating fragrances shall not exceed the maximum allowable documented amount in GB 2760

Chemical properties

It appears as colorless to pale yellow slightly viscous oil. When placed in air and light, its color becomes darker. It has spicy, cool incense, herbs incense with thymol-like smell. It has a boiling point of 238 ° C, the melting point of 0.5 to 1 ° C and the flash point of 100 ° C. It is soluble ethanol, ethyl ether, propylene glycol and alkali, do not dissolve in water. It is miscible in oil.
The natural products are found in thyme oil (about 70%), oregano oil (about 80%) and mange to oil and so on.


Spices; It is mainly used for the preparation of dill, girofle, meat, peppermint, vanilla flavor and so on.
It can be used for the preparation of spices, fungicides and disinfectants. As a spice, it can be used in toothpaste, soap and other daily necessities, but also for food flavors.
It can be used for spices, food additives, feed additives, antioxidants, sanitation fungicide, insect repellent, preservatives, deodorant and pharmaceutical intermediates.


It can be obtained through treatment of the essential oil containing rich content of natural carvacrol followed by ether extraction or steam distillation to derive it.
It can be derived by the sulfonation of thymol followed by alkali treatment.



Toxic classification

middle-level poisoning

Acute toxicity

Oral-rat LD50: 810 mg/kg; intravenous-mouse LD50: 80 mg/kg
Stimulation Data Skin-Rabbit 500 mg/24 h Severe

Flammability and Hazardous characteristics

It is flammable upon heat, fire and strong oxidants with thermal decomposition releasing spicy stimulated smoke

Storage and transportation characteristics

Treasury: low temperature, ventilated and dry; avoid fire and high temperature; store it separately from oxidant.

Extinguishing agent

fog, carbon dioxide, foam, dry powder

Chemical Properties


Chemical Properties

Carvacrol has a characteristic pungent, warm odor. The commercial product consists of a mixture of isomers differing because of the position of the isopropyl radical. The odor characteristics differ between the technical (lower grade) and pure (higher grade) commercial products.


Reported found in cumin seed, thyme, oregano, calamus, lovage, myrtle and lemon balm.


Carvacrol is a flavoring agent that is a colorless to pale yellow liquid. it has a spicy and pungent odor, resembling thymol. it is insoluble in water and soluble in alcohol and ether. it is a mixture of the isomeric carvacrols (isopropyl o-creols), and is obtained by chemical synthesis. it is also an ingredient of savory, a fragrant herb in nature.


As disinfectant; in organic syntheses.


ChEBI: A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).


From p-cymene by sulfonation and subsequent alkali fusion.

Aroma threshold values

Detection at 2.29 ppm.

Taste threshold values

Taste characteristics at 5.0 ppm: spicy, herbal phenolic, medicinal and woody.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 2545, 1978 DOI: 10.1016/S0040-4039(01)94822-1

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Moderately toxic by skin contact. A severe skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Carvacrol Preparation Products And Raw materials

Raw materials

Preparation Products

Carvacrol Suppliers

Global( 357)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
+86-25-86189616 CHINA 128 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8882 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 3001 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29961 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897 CHINA 2712 58
hdzhl biotechnology co., ltd
86-13032617415 CHINA 1275 58

View Lastest Price from Carvacrol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-26 Carvacrol
US $5.70 / Kg/Drum 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-07-13 Carvacrol
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Carvacrol
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Carvacrol Spectrum

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