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Cetirizine hydrochloride

Description References
Cetirizine hydrochloride
Cetirizine hydrochloride structure
CAS No.
83881-52-1
Chemical Name:
Cetirizine hydrochloride
Synonyms
Triz;Zeran;Cesta;Ryzen;Zirtin;Zirtec;Virlix;ZYRTEC;Alerid;Cetrak
CBNumber:
CB6135030
Molecular Formula:
C21H26Cl2N2O3
Formula Weight:
425.35
MOL File:
83881-52-1.mol

Cetirizine hydrochloride Properties

Melting point:
110-115°C
storage temp. 
Desiccate at RT
solubility 
H2O: soluble5mg/mL, clear
form 
powder
color 
white to beige
Water Solubility 
Soluble in water, DMSO, ethanol, and methanol.
Merck 
14,2022
CAS DataBase Reference
83881-52-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  AG0977500
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339900
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Cetirizine hydrochloride price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 89126 Cetirizin dihydrochloride ≥98.0% (HPLC) 83881-52-1 1g-f $63.3 2018-11-13 Buy
Sigma-Aldrich 1102929 Cetirizine dihydrochloride United States Pharmacopeia (USP) Reference Standard 83881-52-1 250mg $352.8 2018-11-13 Buy
TCI Chemical C2316 Cetirizine Dihydrochloride >98.0%(HPLC)(T) 83881-52-1 5g $95 2018-11-22 Buy
TCI Chemical C2316 Cetirizine Dihydrochloride >98.0%(HPLC)(T) 83881-52-1 25g $327 2018-11-22 Buy
Alfa Aesar J63549 Cetirizine dihydrochloride, 99+% 83881-52-1 10g $215 2018-11-13 Buy

Cetirizine hydrochloride Chemical Properties,Uses,Production

Description

Cetirizine hydrochloride is an orally-active and selective histamine (H1)-receptor antagonist. It is a second-generation antihistamine and a human metabolite of hydroxyzine. Three important features of cetirizine are: a high specificity fort he H1-receptor; a low need for metabolism, and the existence of non-H1-dependent activities on cells involved in the pathogenesis of allergy.
Cetirizine is used to treat seasonal allergic rhinitis (SAR), perennial allergic rhinitis, useful in treating urticaria and atopic dermatitis. Cetirizine possesses also mild anti-inflammatory effects.

References

[1] E. J. Corey and Christopher J. Helal, Catalytic Enantioselective Synthesis of the Second-Generation Histamine Antagonist Cetirizine Hydrochloride, Tetrahedron Letters, 1996, vol. 37, 4837-4840
[2] Jay M. Portnoy and Chitra Dinakar, Review of cetirizine hydrochloride for the treatment of allergic disorders, Journal of Expert Opinion on Pharmacotherapy, 2004, vol. 5, 125-135

Description

Cetirizine hydrochloride is a once-daily, non-sedating antihistamine useful in the treatment of allergic rhinitis, urticaria and conjunctivitis. It is reported to be more effective than most other agents in this category such as terfenadine and astemizole.

Chemical Properties

Crystalline Solid

Originator

UCB (Belgium)

Uses

respiratory stimulant

Uses

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

Uses

long acting calcium channel blocker

Uses

Antihistaminic

brand name

Zyrtec (Pfizer).

Biological Activity

Histamine H 1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μ M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo .

Cetirizine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Cetirizine hydrochloride Suppliers

Global( 237)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32606 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24212 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6402 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24093 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4696 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8416 58

View Lastest Price from Cetirizine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Cetirizine hydrochloride
83881-52-1
US $1.00 / KG 1G 98% 100KG career henan chemical co

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