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Papain structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Papain Properties

Flash point:
29 °C
storage temp. 
H2O: soluble1.2mg/mL
lyophilized powder
almost white
Water Solubility 
Soluble in water, insoluble in most organic solvents.
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  42/43-42-36/37/38-20/21/22-10
Safety Statements  36-36/37-26-24-22-45-23-36/37/39
WGK Germany  3
RTECS  RU4950000
HS Code  35079090
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P405 Store locked up.

Papain price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5125-50GM-M Papain from papaya latex 9001-73-4 50gm-m $78.3 2018-11-20 Buy
Sigma-Aldrich 1495005 Papain from Carica papaya United States Pharmacopeia (USP) Reference Standard 9001-73-4 1g $424 2018-11-13 Buy
Alfa Aesar J61875 Papain, Carica Papaya Latex 9001-73-4 25mg $78.7 2018-11-13 Buy
Alfa Aesar J61875 Papain, Carica Papaya Latex 9001-73-4 1g $773 2018-11-13 Buy
Sigma-Aldrich 76218 Papain from Carica papaya powder, almost white, ~12 U/mg 9001-73-4 1g $898 2018-11-13 Buy

Papain Chemical Properties,Uses,Production

Chemical Properties

cream to light brown powder


Papain may cause allergic manifestation .Person handling this material should be protected against inhalation of dust and contact with the skin or eyes.


For tenderizing meats; for clearing beverages; for bating skins.


papain is a papaya enzyme able to dissolve keratin. Papain is used in face masks and peeling lotions as a very gentle exfoliant. It can be irritating to the skin but less so than bromelin, a similar enzyme found in pineapples and also used in cosmetics. It is considered a non-comedogenic raw material.


Papain is a tenderizer that is a protein-digesting enzyme obtained from the papaya fruit. the enzyme, used in a patented process, is injected into the circulatory system of the live animal and is activated by the heat of cooking to break down the protein, thus tenderizing the beef. the enzyme is inactivated by stomach acids.


papain: A protein-digesting enzymeoccurring in the fruit of the West Indianpapaya tree (Carica papaya). It isused as a digestant and in the manufactureof meat tenderizers.

brand name

Caroid (Sterling Winthrop).

General Description

Papain (Papase), the dried and purifiedlatex of the fruit of Carica papaya L. (Caricaceae), can digestprotein in either acidic or alkaline media; it is best at a pH between4 and 7 and at 65°C to 90°C. It occurs as light brownishgray to weakly reddish brown granules, or as a yellowishgray to weakly yellow powder. It has a characteristic odor andtaste and is incompletely soluble in water to form an opalescentsolution. The commercial material is prepared by evaporatingthe juice, but the pure enzyme has also been preparedand crystallized. In medicine, it has been used locally in variousconditions similar to those for which pepsin is used. Ithas the advantage of activity over a wider range of conditions,but it is often much less reliable. Intraperitoneal instillation ofa weak solution has been recommended to counteract a tendencyto develop adhesions after abdominal surgery, and severalenthusiastic reports have been made about its value underthese conditions. Papain has been reported to cause allergiesin persons who handle it, especially those who are exposed toinhalation of the powder.

Safety Profile

Poison by intraperitoneal route. Human systemic effects by ingestion: changes in structure or function of esophagus. Experimental teratogenic and reproductive effects. An allergen. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

A suspension of 50g of papain (freshly ground in a mortar) in 200mL of cold water is stirred at 4o for 4hours, then filtered through a Whatman No 1 filter paper. The clear yellow filtrate is cooled in an ice-bath while a rapid stream of H2S is passed through it for 3hours, and the suspension is centrifuged at 2000rpm for 20minutes. Sufficient cold MeOH is added slowly with stirring to the supernatant to give a final MeOH concentration of 70 vol%. The precipitate, collected by centrifugation for 20minutes at 2000rpm, is then dissolved in 200mL of cold water, the solution is saturated with H2S, centrifuged, and the enzyme is again precipitated with MeOH. The process is repeated four times. [Bennett & Niemann J Am Chem Soc 72 1798 1950.] Papain has also been purified by affinity chromatography on a column of GlyGlyTyrArg-agarose [Stewart et al. J Am Chem Soc 109 3480 1986].

Papain Preparation Products And Raw materials

Raw materials

Preparation Products

Papain Suppliers

Global( 172)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2561 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 892 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20095 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4669 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 CHINA 748 58
hdzhl biotechnology co., ltd
86-13032617415 CHINA 500 58
Kono Chem Co., Ltd
+86-132 8924 6953 CHINA 2144 58

View Lastest Price from Papain manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-31 Papain
US $150.00 / KG 1KG 98% 1000kg career henan chemical co

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