S-4-bromobenzylglutathione cyclopentyl diester
- CAS No.
- 166038-00-2
- Chemical Name:
- S-4-bromobenzylglutathione cyclopentyl diester
- Synonyms
- BBGC;BBGD;BrBzGCp2;BrBzGCp2,BrBzGCp-2;S-p-Bromobenzylglutathione cyclopentyl diester;S-4-bromobenzylglutathione cyclopentyl diester;S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC);Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
- CBNumber:
- CB61384475
- Molecular Formula:
- C27H38BrN3O6S
- Molecular Weight:
- 612.58
- MDL Number:
- MFCD28976196
- MOL File:
- 166038-00-2.mol
S-4-bromobenzylglutathione cyclopentyl diester price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1306 | S-p-Bromobenzylglutathione cyclopentyl diester ≥98% (HPLC) | 166038-00-2 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1306 | S-p-Bromobenzylglutathione cyclopentyl diester ≥98% (HPLC) | 166038-00-2 | 25MG | $451 | 2023-06-20 | Buy |
S-4-bromobenzylglutathione cyclopentyl diester Chemical Properties,Uses,Production
Uses
S-p-Bromobenzylglutathione cyclopentyl diester has been used as an inhibitor of glyoxalase 1?(GLO-1) enzyme to treat HL-1 cardiomyocytes for stimulating aging-based glycative stress. It has also been used as an inhibitor of GLO-1 in hepatic stellate cells.
Biochem/physiol Actions
S-p-Bromobenzylglutathione cyclopentyl diester (BBGC) is a cell-permeable inhibitor of Glyoxalase 1 (GLO1), an enzyme that detoxifies methylglyoxal, a toxic side-product of glycolysis that induces apoptosis at high levels and has been linked to arterial atherogenesis in diabetics. However, tumors use GLO as well and overexpression of GLO1 has been reported in a number of cancers, so GLO1 inhibitors including BBCG have been investigated as possible anticancer agents. Recent studies have indicated that methylglyoxal has some beneficial effects at low levels with GABAA receptor agonist activity, and that GLO1 inhibition with BBGC can reduce anxiety-like behavior and decrease antiseizure activity. S-p-bromobenzylglutathione cyclopentyl diester should be an inportant tool to study the glyoxalase system.
S-4-bromobenzylglutathione cyclopentyl diester Preparation Products And Raw materials
Raw materials
Preparation Products
S-4-bromobenzylglutathione cyclopentyl diester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29802 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11976 | 58 |