2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
- CAS No.
- 104206-65-7
- Chemical Name:
- 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
- Synonyms
- NTBC;CS-99;SC 0735;Orfadin;Nitisone;NITISONONE;Nitisinone (NTBC);NTBC;NITISONE;SC0735;ORFADIN;2-[2-Nitro-4-(trifluoroMethyl)benzoyl]-;2-(2-Nitro-4-Trifluoromethylbenzoyl)Cyclohexane-1,
- CBNumber:
- CB61386686
- Molecular Formula:
- C14H10F3NO5
- Molecular Weight:
- 329.23
- MDL Number:
- MFCD01752192
- MOL File:
- 104206-65-7.mol
- MSDS File:
- SDS
| Melting point | 129-131°C |
|---|---|
| Boiling point | 486.2±45.0 °C(Predicted) |
| Density | 1.484±0.06 g/cm3(Predicted) |
| RTECS | GV0766666 |
| storage temp. | -20°C |
| solubility | DMSO: ≥5mg/mL |
| pka | 3.13±0.50(Predicted) |
| form | Solid |
| color | white to brown |
| InChIKey | OUBCNLGXQFSTLU-UHFFFAOYSA-N |
| FDA UNII | K5BN214699 |
| EPA Substance Registry System | 1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]- (104206-65-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H311-H302 | |||||||||
| Precautionary statements | P280-P302+P352-P312-P322-P361-P363-P405-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0269 | Nitisinone ≥95% (HPLC) | 104206-65-7 | 10mg | $67.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1731 | Nitisinone | 104206-65-7 | 1g | $267 | 2024-03-01 | Buy |
| Alfa Aesar | H66633 | 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, 95% | 104206-65-7 | 250mg | $90.65 | 2024-03-01 | Buy |
| Alfa Aesar | H66633 | 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, 95% | 104206-65-7 | 1g | $266.65 | 2024-03-01 | Buy |
| Cayman Chemical | 17924 | Nitisinone ≥98% | 104206-65-7 | 50mg | $32 | 2024-03-01 | Buy |
2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione Chemical Properties,Uses,Production
Description
Nitisinone was originally developed as a pesticide and then launched as an adjunct to dietary restriction of tyrosine and phenylalanine for the treatment of hereditary tyrosinaemia type I. In this inborn error of metabolism, fatal liver disease results either from liver failure during infancy or early childhood or from development of hepatocellular carcinoma during childhood or adolescence. This is caused by accumulation of toxic metabolites due to deficiency of fumarylacetoacetase, the last enzyme of the tyrosine catabolic pathway. Nitisinone, which acts as an inhibitor of the 4-hydroxyphenylpyruvate dioxygenase, prevents the formation of toxic metabolites such as succinylacetoacetate in the liver. Administration of a single dose of nitisinone in mice showed a rapid, significant and persistent inhibition of 4-hydroxyphenylpyruvate dioxygenase. In a murine model of tyrosinaemia type I, administration of nitisinone abolished acute liver failure. Additional dietary tyrosine restriction in the same model on long term follow-up (> 2 years) showed complete correction of liver function tests and succinylacetone levels, and cancer-free survival improvements when compared to historical controls. In healthy volunteers, nitisinone was well tolerated, peak plasma concentrations were rapidly attained following a single dose of 1 mglkg and the half-life time was approximately 54 h. Following the administration of nitisinone (1 mg/kg), the concentrations of tyrosine in plasma increased, were still 8 times those of background at 14 days after dosing, but had returned to background levels within 2 months of the second dose. Elevated tyrosine levels are a potential risk of cornea1 opacities. No treatment related comeal lesions were seen after administration of high dose of nitisinone in mice. In children diagnosed when they were less than 2 months old, when nitisinone treatment was combined with a restricted diet, the four-year survival rate was 88%, compared to 29% from historical data of children treated with restricted diet alone. So, there is some clear evidence that nitisinone treatment associated with restricted diet can reduce the risk of early hepatocellular carcinoma when started before two years of age. On the contrary, in patients with late start of nitisinone treatment there is a considerable risk of liver malignancy. Even if 10% of patients have not clinically responded to nitisinone, studies have shown that oral nitisinone treatment plus dietary restriction has greatly improved the survival of patients and reduced the need of liver transplantation during early childhood.
Chemical Properties
Light Brown Solid
Originator
AstraZeneca (UK)
Uses
Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
Uses
Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is u sed in treatment of inherited tyrosinemia type I.
Definition
ChEBI: A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.
brand name
. Orfadin (Swedish Orphan).
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Nitisinone is a medication, effectively used for the treatment and maintainence of alkaptonuria, an autosomal recessive disease. Its mode of action involves the inhibition of second enzyme in the tyrosine pathway, 4-hydroxyphenylpyruvate dioxygenase that produces HGA from 4-hydroxyphenylpyruvate.
Biochem/physiol Actions
Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances.
2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 13854 | 58 |
View Lastest Price from 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-31 | 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
104206-65-7
|
US $0.00-0.00 / kg | 1kg | 98.0% | 10000kg | LY Global chemicals co.,ltd . | |
 |
2019-07-06 | 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
104206-65-7
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
104206-65-7
- US $0.00-0.00 / kg
- 98.0%
- LY Global chemicals co.,ltd .
-
- 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
104206-65-7
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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