ChemicalBook >> CAS DataBase List >>dolastatin 10

dolastatin 10

dolastatin 10 structure

CAS No.: 110417-88-4

Chemical Name:: dolastatin 10

Synonyms: DLS 10;CS-1367;Nsc376128;Dolastain10;B720389K560;dolastatin 10;Dolastatin 10 (NSC-376128);Dolastatin 10，DLS 10，NSC 376128;From dolabella auricularia (sea hare);Dolastatin 10,DLS 10,NSC 376128, >99%

CBNumber:: CB61390632

Molecular Formula:: C42H68N6O6S

Molecular Weight:: 785.09

MDL Number:: MFCD00870128

MOL File:: 110417-88-4.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

Request For Quotation

dolastatin 10 Properties

Boiling point	903.6±65.0 °C(Predicted)
Density	1.116±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	≥78.5 mg/mL in EtOH; insoluble in H2O; ≥67.2 mg/mL in DMSO
form	Powder
pka	13.81±0.46(Predicted)
NCI Dictionary of Cancer Terms	dolastatin 10
FDA UNII	EI946JT51X
NCI Drug Dictionary	dolastatin 10

SAFETY

Risk and Safety Statements

RIDADR	3172
HazardClass	6.1(b)
PackingGroup	III

dolastatin 10 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1825	Dolastatin10 98.52%	110417-88-4	1mg	$300	2021-12-16	Buy
ApexBio Technology	B1035	Dolastatin10	110417-88-4	1mg	$523	2021-12-16	Buy
ChemScene	CS-1825	Dolastatin10 98.52%	110417-88-4	5mg	$800	2021-12-16	Buy
ApexBio Technology	B1035	Dolastatin10	110417-88-4	5mg	$1425	2021-12-16	Buy
CSNpharm	CSN17468	Dolastatin10	110417-88-4	1mg	$279	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-1825	1mg	$300	Buy
B1035	1mg	$523	Buy
CS-1825	5mg	$800	Buy
B1035	5mg	$1425	Buy
CSN17468	1mg	$279	Buy

dolastatin 10 Chemical Properties,Uses,Production

Definition

ChEBI: Dolastatin 10 is a tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization. It has a role as an animal metabolite, a marine metabolite, an antineoplastic agent, an apoptosis inducer and a microtubule-destabilising agent. It is a member of 1,3-thiazoles and a tetrapeptide. It is functionally related to a L-valine.

Biological Activity

dolastatin 10 is an antitumor agent [1].dolastatin 10 is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. dolastatin 10 is found to have activity to inhibit tubulin polymerization with ic50 value of 1.2μm. besides that, it potently inhibits vincristine binding to tubulin with a ki value of 1.4μm in a noncompetitive manner. dolastatin 10 also shows moderate effect on enhancing the binding of colchicines to tubulin. in addition, dolastatin 10 has the inhibitory activity in tubulin-dependent gtp binding [1].in the cellular assay, dolastatin 10 shows activity against some human leukaemia, lymphoma and solid tumour cell lines (such as ovcar-3 and nsclc) with ic50 values ranging from 0.1nm to 10nm. it is currently tested in the

in vitro

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI < sub> 50 values of 10 ^?5 -10 ^?6 μg/mL (10 ^?2 -10 ^{? 3} nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.

target

Auristatin

References

[1] bai r l, pettit g r, hamel e. binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. journal of biological chemistry, 1990, 265(28): 17141-17149.
[2] schwartsmann g. marine organisms and other novel natural sources of new cancer drugs. annals of oncology, 2000, 11(suppl 3): 235-243.

dolastatin 10 synthesis

Synthesis of dolastatin 10 from BOC-L-Isoleucine

dolastatin 10 Preparation Products And Raw materials

Raw materials

2-PyrrolidinepropanaMide, β-Methoxy-α-Methyl-N-[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]-, (αR,βR,2S)- Carbamic acid, [(1S,2S)-1-formyl-2-methylbutyl]methyl-, phenylmethyl ester (9CI) Heptanoic acid, 3-hydroxy-5-methyl-4-[methyl[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3S-(3R*,4R*,5R*)]- (9CI) benzyl ((2S,3S)-1-hydroxy-3-methylpentan-2-yl)(methyl)carbamate Heptanoic acid, 3-methoxy-5-methyl-4-[methyl[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, [3S-(3R*,4R*,5R*)]- (9CI)

N-Cbz-L-Isoleucine N-BOC-L-Prolinal 1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-Methoxy-2-Methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]aMino]propyl]-, 1,1-diMethylethyl ester, (2S)- SXCDYMWHVBJDJZ-ZXHYAQOVSA-N N,N-DIMETHYL-L-VALINE

(3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride N-Boc-(2R,3R,4S)-dolaproine BOC-L-Isoleucine

1of3

Preparation Products

dolastatin 10 Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Zhuoer Chemical Co., Ltd	02120970332; +8613524231522	sales@zhuoerchem.com	China	3015	58
ChemExpress	+86-021-58950125	info@chemexpress.com	China	557	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Zhuoer Chemical Co., Ltd	58
ChemExpress	58
Nextpeptide Inc	58
Nantong HI-FUTURE Biology Co., Ltd.	58

dolastatin 10 Spectrum

dolastatin 10(110417-88-4)MS

110417-88-4(dolastatin 10)Related Search:

(2S)-2-[[(2S)-2-dimethylamino-3-methyl-butanoyl]amino]-N-[(3R,4S,5S)-3 -methoxy-1-[(3R)-3-[(1R,2R)-1-methoxy-2-(phenethylcarbamoyl)propyl]pyr rolidin-1-yl]-5-methyl-1-oxo-heptan-4-yl]-N,3-dimethyl-butanamide Butanamide, 3-methyl-N-(4-oxo-4-(propylamino)butyl)- 4,9-dioxo-5,10-diazatetradecane N-Methylthiazole-2-methanamine dolastatin 10

2-(4-Aminopentyl(ethyl)amino)ethanol ETHYLENEDIAMINE TETRAKIS(PROPOXYLATE-BLOCK-ETHOXYLATE) TETROL

1of2

(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide dolastatin 10 B720389K560 From dolabella auricularia (sea hare) L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]- Nsc376128 DLS 10 Dolastain10 Dolastatin 10 (NSC-376128) L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl- CS-1367 Dolastatin 10,DLS 10,NSC 376128, >99% L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl- 6-[bis[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl] amino]-6-oxohexanoic acid (S)-2-((S)-2-(Dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide ADC Cytotoxin,Dolastatin-10,Dolastatin 10,DLS10,inhibit,NSC376128,DLS-10,NSC-376128,Dolastatin10,Inhibitor,ADC Payload,Microtubule/Tubulin Dolastatin 10，DLS 10，NSC 376128 110417-88-4 C42H68N6O6S ADCs