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DL-PROPARGYLGLYCINE

DL-PROPARGYLGLYCINE structure

CAS No.: 64165-64-6

Chemical Name:: DL-PROPARGYLGLYCINE

Synonyms: NSC21940;DL-Pra-OH;H-DL-PRA-OH;H-DL-Prg-OH;DL-PROPARGYL-GLY-OH;DL-PROPARGYLGLYCINE;DL-Gly(Propargyl)-OH;H-PROPARGYL-DL-GLY-OH;H-DL-GLY(PROPARGYL)-OH;H-PROPARGYL-DL-GLYCINE

CBNumber:: CB6140609

Molecular Formula:: C5H7NO2

Molecular Weight:: 113.11

MDL Number:: MFCD00056728

MOL File:: 64165-64-6.mol

MSDS File:: SDS

Last updated:2023-05-09 09:30:46

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DL-PROPARGYLGLYCINE Properties

storage temp.	-20°C
solubility	Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
form	Crystalline Powder
color	White to off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
FDA UNII	FU67PLJ48R

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

DL-PROPARGYLGLYCINE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P7888	DL-Propargylglycine cystathionine γ-lyase inhibitor	64165-64-6	1g	$226	2024-03-01	Buy
Sigma-Aldrich	P7888	DL-Propargylglycine cystathionine γ-lyase inhibitor	64165-64-6	5g	$345.2	2024-03-01	Buy
Sigma-Aldrich	P7888	DL-Propargylglycine cystathionine γ-lyase inhibitor	64165-64-6	250mg	$77.4	2024-03-01	Buy
Usbiological	287837	DL-Propargylglycine	64165-64-6	500mg	$333	2021-12-16	Buy
Chem-Impex	07081	DL-Propargylglycine,≥98% ≥98%	64165-64-6	1G	$96.45	2021-12-16	Buy

Product number	Packaging	Price	Buy
P7888	1g	$226	Buy
P7888	5g	$345.2	Buy
P7888	250mg	$77.4	Buy
287837	500mg	$333	Buy
07081	1G	$96.45	Buy

DL-PROPARGYLGLYCINE Chemical Properties,Uses,Production

Description

Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.

Chemical Properties

White to off-white powder

Uses

Dl-propargylglycine is an inhibitor of hydrogen sulfide (H2S) production.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 3484, 1954 DOI: 10.1021/ja01642a036
Tetrahedron Letters, 22, p. 1787, 1981 DOI: 10.1016/S0040-4039(01)90439-3

Biochem/physiol Actions

DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).

References

1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141

DL-PROPARGYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

DL-PROPARGYLGLYCINE Suppliers

Global( 112)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3465	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
GenicBio Limited	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Hubei Ipure Biology Co., Ltd	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Dideu Industries Group Limited	58

View Lastest Price from DL-PROPARGYLGLYCINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	DL-PROPARGYLGLYCINE 64165-64-6	US $10.00 / KG	10KG	99%	100kg	Career Henan Chemical Co

DL-PROPARGYLGLYCINE
64165-64-6
US $10.00 / KG
99%
Career Henan Chemical Co

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H-PROPARGYL-DL-GLYCINE H-PROPARGYL-DL-GLY-OH H-DL-PRA-OH H-DL-GLY(PROPARGYL)-OH DL-PROPARGYLGLYCINE DL-PROPARGYL-GLY-OH 2-AMINO-4-PENTYNOIC ACID NSC21940 DL-Propargylglycine hydrochloride DL-Propargylglycine DL-Propargylglycine H-Propargyl-DL-Gly-OH, (RS)-2-AMino-4-pentynoic acid DL-Propargylglycine cystathionine γ-lyase inhibitor DL-Pra-OH DL-Gly(Propargyl)-OH H-DL-Prg-OH DL-PROPARGYLGLYCINE, CYSTATHIONINE G H-DL-Pra-OH DL-Propargylglycine DL-PROPARGYLGLYCINE USP/EP/BP 64165-64-6 16800-57-5 BioChemical Biochemicals and Reagents Amino Acids and Peptides Modified Amino Acids I - Z Amino Acids