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Phenacetin

Indications and Usage Mechanisms of Action Side Effects
Phenacetin
Phenacetin
CAS No.
62-44-2
Chemical Name:
Phenacetin
Synonyms
Kafa;Soma;Dasin;Fenia;Malex;Tacol;Viden;Xaril;Anapac;Fenina
CBNumber:
CB6141828
Molecular Formula:
C10H13NO2
Formula Weight:
179.22
MOL File:
62-44-2.mol

Phenacetin Properties

Melting point:
133-136 °C(lit.)
Boiling point:
132 °C / 4mmHg
Density 
1.1248 (rough estimate)
refractive index 
1.5710
Flash point:
2℃
storage temp. 
2-8°C
form 
powder
color 
White
Water Solubility 
0.076 g/100 mL
Sensitive 
Hygroscopic
Merck 
14,7204
BRN 
1869238
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids.
InChIKey
CPJSUEIXXCENMM-UHFFFAOYSA-N
CAS DataBase Reference
62-44-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N-(4-ethoxyphenyl)-(62-44-2)
EPA Substance Registry System
Acetamide, N-(4-ethoxyphenyl)-(62-44-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,F
Risk Statements  45-22-20/21/22-36-11
Safety Statements  53-45-36/37-26-16
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  AM4375000
TSCA  Yes
Hazardous Substances Data 62-44-2(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1.65 g/kg (Boyd)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Phenacetin price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1514008 Phenacetin United States Pharmacopeia (USP) Reference Standard 62-44-2 1g $206.3 2017-11-08 Buy
Sigma-Aldrich 1513005 Phenacetin United States Pharmacopeia (USP) Reference Standard 62-44-2 500mg $342.9 2017-11-08 Buy
TCI Chemical P1669 Phenacetin >99.0%(GC) 62-44-2 25g $14 2017-12-01 Buy
TCI Chemical P1669 Phenacetin >99.0%(GC) 62-44-2 500g $54 2017-12-01 Buy
Alfa Aesar A11200 4'-Ethoxyacetanilide, 97% 62-44-2 100g $27.4 2017-11-08 Buy

Phenacetin Chemical Properties,Uses,Production

Indications and Usage

Phenacetin is mainly used as an antipyretic analgesic, with slow and lasting effects, treating headaches, neuralgia, joint pain, and fever, and weakly resisting rheumatism and inflammation. Because of toxic side effects and the rapid development of similar drugs, however, it is no longer used alone, only as a raw material in combination with other drugs. Commonly combined with aspirin and caffeine to form a less toxic compound aspirin used to treat the common cold. Can make chlorpheniramine cold tablets by adding a small amount of chlorpheniramine to the above compound, used to treat colds with headache, neuralgia, rheumatism, etc. Can be used as a material for organic synthesis or a pharmaceutical intermediate.

Mechanisms of Action

On its own, phenacetin has no antipyretic or analgesic effects. In vivo, acetaminophen and paracetamol are metabolized and decomposed to create the antipyretic and analgesic effects. Its decomposites with ammonia and phenyl either not only have no antipyretic and analgesic effects, but also are major factors in its side effects.

Side Effects

Long term use may cause renal papillary necrosis and interstitial nephritis, and even induce renal pelvic cancer and bladder cancer. Phenacetin also makes the hemoglobin to form methemoglobin, decreasing blood oxygen carrying capacity, causing cyanosis. In addition, Phenacetin can cause hemolysis and hemolytic anemia, and is toxic to the retina. Long term use may cause also lead to dependence. Countries including America, Britain, German, and Japan have banned Phenacetin, or required packaging to note that it is “not indicated for long-term usage or large doses.”

Chemical Properties

white crystalline powder

Uses

Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.

Uses

glycosylation inhibitor

Definition

ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.

General Description

Odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phenacetin react with oxidizing agents, iodine and nitrating agents.

Fire Hazard

Flash point data for Phenacetin are not available but Phenacetin is probably combustible.

Purification Methods

Crystallise it from H2O or EtOH, and its solubility in H2O is 0.08% (at ~10o) and 1.2% (at ~100o), and in EtOH it is 6.7% (at ~10o) and 36% (at ~100o). Alternatively it can be purified by solution in cold dilute alkali and re-precipitating by addition of acid to neutralisation point. Dry it in air. [Beilstein 13 H 461, 13 IV 1092.]

Phenacetin Preparation Products And Raw materials

Raw materials

Preparation Products


Phenacetin Suppliers

Global( 243)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Huanhao Biotechnology Co., Ltd.
18932942939
lyla@hbhuanhao.com CHINA 194 58
Dalian Pinmai Export and Import Trading Co., Ltd
+86-13230167943
pinmai04@dlpinmai.com CHINA 293 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1428 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 418 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22144 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 294 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20803 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32765 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
bruce@xrdchem.cn CHINA 511 55

View Lastest Price from Phenacetin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-28 Phenacetin
62-44-2
US $21.00 / KG 1KG 99% 100ton/month Dalian Pinmai Export and Import Trading Co., Ltd
2018-09-17 Phenacetin
62-44-2
US $20.00 / KG 1KG 99% 20mt -
2018-09-05 Phenacetin
62-44-2
US $10.00 / KG 1KG 99.9% 100Ton/month Hebei Ruishun Trade Co.,Ltd

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