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2,2-Dimethylthiopropionamide

CAS No.
630-22-8
Chemical Name:
2,2-Dimethylthiopropionamide
Synonyms
NSC 381432;Thiopivalamide;Neopentanethioamide;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide;Propanethioamide, 2,2-dimethyl-
CBNumber:
CB61449866
Molecular Formula:
C5H11NS
Molecular Weight:
117.21
MDL Number:
MFCD09742834
MOL File:
630-22-8.mol
MSDS File:
SDS
Last updated:2024-03-22 21:24:34

2,2-Dimethylthiopropionamide Properties

Melting point 117-119℃ (ethyl acetate hexane )
Boiling point 162.1±23.0℃ (760 Torr)
Density 0.978±0.06 g/cm3 (20 ºC 760 Torr)
Flash point 51.9±22.6℃
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
form Solid
pka 13.33±0.29(Predicted)
color White
Water Solubility Soluble in water (10 g/L) (25°C).
InChI InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
InChIKey FJZJUSOFGBXHCV-UHFFFAOYSA-N
SMILES C(N)(=S)C(C)(C)C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
HS Code  2930909899
NFPA 704
1
2 0

2,2-Dimethylthiopropionamide price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar H32092 2,2,2-Trimethylthioacetamide, 97% 630-22-8 1g $53.65 2024-03-01 Buy
Alfa Aesar H32092 2,2,2-Trimethylthioacetamide, 97% 630-22-8 10g $315.65 2024-03-01 Buy
TRC T796135 2,2-Dimethylthiopropionamide 630-22-8 1g $50 2021-12-16 Buy
AK Scientific 9562AB 2,2,2-Trimethylthioacetamide 630-22-8 1g $38 2021-12-16 Buy
AK Scientific J99033 2,2,2-Trimethylthioacetamide 630-22-8 5g $88 2021-12-16 Buy
Product number Packaging Price Buy
H32092 1g $53.65 Buy
H32092 10g $315.65 Buy
T796135 1g $50 Buy
9562AB 1g $38 Buy
J99033 5g $88 Buy

2,2-Dimethylthiopropionamide Chemical Properties,Uses,Production

Uses

2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).

Synthesis

To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).

754-10-9
630-22-8
Synthesis of 2,2-Dimethylthiopropionamide from PIVALAMIDE

2,2-Dimethylthiopropionamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 129)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 47 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5085 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 chloewu@chicopharm.cn CHINA 341 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58

View Lastest Price from 2,2-Dimethylthiopropionamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2-Dimethylpropanethioamide pictures 2024-03-26 2,2-Dimethylpropanethioamide
630-22-8
US $0.00-0.00 / kg 1kg 99.0% 20000 Enki Biopharmaceuticals (Shanghai) Limited
2,2-Dimethylthiopropionamide pictures 2024-03-23 2,2-Dimethylthiopropionamide
630-22-8
US $6.00-0.50 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2,2-DIMETHYLTHIOPROPIONAMIDE pictures 2024-01-02 2,2-DIMETHYLTHIOPROPIONAMIDE
630-22-8
US $80.00-800.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
2,2-DIMETHYLTHIOPROPIONAMIDE 2,2,2-Trimethylthioacetamide, Neopentanethioamide NSC 381432 Thiopivalamide 2,2-DIMETHYLTHIOPROPIOMIDE 2,2,2-Dimethylthiopropionamide Propanethioamide, 2,2-dimethyl- 2,2-Trimethylthioacetamide 630-22-8