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Dabigatran

Dabigatran Structure
Dabigatran structure
CAS No.
211914-51-1
Chemical Name:
Dabigatran
Synonyms
BIB-953;CS-1864;BIBR 953;BIBR 953ZW;Dabigatran;Dabiga group;Dabigatran API;Dabigatran base;Dabigatran (Acid);Dabigatran(BIB-953
CBNumber:
CB61458206
Molecular Formula:
C25H25N7O3
Molecular Weight:
471.51
MDL Number:
MFCD09837830
MOL File:
211914-51-1.mol
MSDS File:
SDS
Last updated:2024-04-16 16:23:18
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Dabigatran Properties

Melting point 268-272°C
Boiling point 797.1±70.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Aqueous Acid
form Solid
pka 4.17±0.10(Predicted)
color White to Brown
FDA UNII I0VM4M70GC

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
2 0

Dabigatran price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17133 Dabigatran ≥95% 211914-51-1 1mg $32 2024-03-01 Buy
Cayman Chemical 17133 Dabigatran ≥95% 211914-51-1 5mg $139 2024-03-01 Buy
Cayman Chemical 17133 Dabigatran ≥95% 211914-51-1 10mg $243 2024-03-01 Buy
Cayman Chemical 17133 Dabigatran ≥95% 211914-51-1 50mg $606 2024-03-01 Buy
TRC D100090 Dabigatran 211914-51-1 50mg $525 2021-12-16 Buy
Product number Packaging Price Buy
17133 1mg $32 Buy
17133 5mg $139 Buy
17133 10mg $243 Buy
17133 50mg $606 Buy
D100090 50mg $525 Buy

Dabigatran Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

Nonpeptide, direct thrombin inhibitor. Antithrombotic.

Uses

BIBR 953 (Dabigatran, Pradaxa) is potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-b ta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.

Biological Activity

bibr 953 is a potent, reversible, and direct inhibitor of thrombin with ic50 value of 9.3nm [1].bibr 953 shows a favorable selectivity profile and strong activity in vitro with a ki value of 4.5nm. it also exhibits the best activity profile in vivo following administration to rats. bibr 953 is designed to be converted into an orally active prodrug bibr 1048 due to its highly polar, zwitterionic nature and poor oral absorption. bibr 953 inhibits thrombin in a competitive fashion. this inhibition is rapid and reversible. bibr 953 inhibits both clot-bound and free thrombin. bibr 953 is demonstrated to have an anticoagulant efficacy both in vitro and ex vivo. since thrombin can affect cell behavior and response in various tissue types via par signaling, bibr 953 is found to be beneficial in many diseases including inflammation, infection, fibrosis and cancer.

target

thrombin

References

[1] hauel nh, nar h, priepke h, ries u, stassen jm, wienen w. structure-based design of novel potent nonpeptide thrombin inhibitors. j med chem. 2002 apr 25;45(9):1757-66.
[2] van ryn j, goss a, hauel n, wienen w, priepke h, nar h, clemens a. the discovery of dabigatran etexilate. front pharmacol. 2013 feb 12;4:12.

Dabigatran Preparation Products And Raw materials

Raw materials

Preparation Products

Dabigatran Suppliers

Global( 282)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Shochem(Shanghai) Co.,Ltd 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58

View Lastest Price from Dabigatran manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dabigatran pictures 2024-04-16 Dabigatran
211914-51-1
 US $5.00-0.10 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
dabigatran pictures 2022-02-25 dabigatran
211914-51-1
 US $1.21 / IU 100g 99% 30kgs Hong Kong Tiansheng New Material Trading Co., Ltd
Dabigatran USP/EP/BP pictures 2021-08-05 Dabigatran USP/EP/BP
211914-51-1
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • Dabigatran pictures
  • Dabigatran
    211914-51-1
  • US $5.00-0.10 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • dabigatran pictures
  • dabigatran
    211914-51-1
  • US $1.21 / IU
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

Dabigatran Spectrum

Dabigatran(211914-51-1)1HNMR

211914-51-1(Dabigatran)Related Search:

Rivaroxaban Dabigatran etexilate Dabigatran Etexilate Mesylate N-(4-CYANO-PHENYL)-GLYCINE Chloroacetic anhydride
4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Bortezomib
Y27632 (hydrochloride) (+)-JQ1 Apixaban 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester 4-methoxy-N-methyl-3-nitrobenzamide
Dabigatran iMpurity K Dabigatran iMpurity D Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity)

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3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Met BIBR 953(Dabigatran) N-[[2-[[[4-(AMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benzo[d]iMidazol-5-yl]carbonyl]-N-pyridin-2-yl-beta-alanine N-[(2-{[(4-carbaMiMidoylphenyl)aMino]Methyl}-1-Methyl-1HbenziMidazol- 5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine BIBR 953 (Dabigatran, Pradaxa) 3-[[2-[[(4-carbaMiMidoylphenyl)aMino]Methyl]-1-Methyl-benzoiMidazole-5-carbonyl]-pyridin-2-yl-aMino] BIB-953 BIBR 953ZW Dabigatran (BIBR 953) N- (2-{ (4-carbaMiMidoylphenyl)aMino Methyl}-1-Met BIBR 953 β-Alanine,N-[[2-[[[4-(aMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl- 3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid Dabigatran (BIBR 953) Dabigatran Impurity b Dabigatran (Acid) 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic Dabigatran3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid 3-[[2-[[(4-carbamimidoylphenyl)amino]methyl]-1-methyl-benzoimidazole-5-carbonyl]-pyridin-2-yl-amino]propanoic acid 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid ethyl 3-(2-(((4-(N'-((hexan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate Dabigatran Etexilate Mesilate Dabigatran Dabigatran Impurity U Dabigatran etexilate-1 BIBR953;BIBR 953;BIBR-953 CS-1864 Dabigatran(BIB-953 BIBR 953;BIBR 953ZW;BIBR953;BIB-953 Dabigatran Ester Impurity B b-Alanine,N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl- N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine Dabigatran USP/EP/BP Dabigatran base Dabiga group N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-ben... Dabigatran etexilate impurity189 Dabigatran etexilate impurity1513 DabigatranQ: What is Dabigatran Q: What is the CAS Number of Dabigatran Q: What is the storage condition of Dabigatran Q: What are the applications of Dabigatran Dabigatran API Dabigatran Standard Dabigatran AKSci B955 3-[2-[[(4-Carbamimidoylphenyl)amino]methyl]-1-methyl-N-(2-pyridyl)benzimidazole-5-carboxamido]propanoic Acid Desethyl Dabigatran Etexilate Impurity D 211914-51-1 C25H25N7O3 Inhibitor Intermediates & Fine Chemicals Nucleotides Pharmaceuticals benzimidazol Dabigatran impurity Aromatics Bases & Related Reagents Heterocycles Inhibitors Other APIs