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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid structure

CAS No.: 641569-94-0

Chemical Name:: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

Synonyms: -3-((4-(pyridin-3-yL;Nilotinib Intemediate 2;Nilotinib EP Impurity D;Nilotinib EP Impurity D/B;4-Methyl-3-((4-(pyridin-3-yl);Nilotinib Carboxylic Acid Impurity;Nilotinib Impurity 6 (Nilotinib EP Impurity D);Nilotinib Hydrochloride Monohydrate EP Impurity D;4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci;4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid

CBNumber:: CB61503982

Molecular Formula:: C17H14N4O2

Molecular Weight:: 306.32

MDL Number:: MFCD11521324

MOL File:: 641569-94-0.mol

MSDS File:: SDS

Last updated:2024-03-04 09:38:27

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Properties

Melting point	>257oC (dec.)
Boiling point	587.9±60.0 °C(Predicted)
Density	1.336
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	4.35±0.10(Predicted)
form	Solid
color	Pale Beige
Stability	Hygroscopic
InChI	InChI=1S/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
InChIKey	LDLZPHLSVKGFSC-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1
CAS DataBase Reference	641569-94-0(CAS DataBase Reference)
FDA UNII	TQ9WCS4PF0

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P261-P271-P280
HS Code	2933599590

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	N465305	4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacid	641569-94-0	5g	$275	2021-12-16	Buy
SynQuest Laboratories	4H21-1-Y0	4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid	641569-94-0	1g	$133	2021-12-16	Buy
Apolloscientific	OR16087	4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid	641569-94-0	250mg	$15	2021-12-16	Buy
Apolloscientific	OR16087	4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid	641569-94-0	1g	$19	2021-12-16	Buy
AK Scientific	J11466	NilotinibImpurity20	641569-94-0	25mg	$39	2021-12-16	Buy

Product number	Packaging	Price	Buy
N465305	5g	$275	Buy
4H21-1-Y0	1g	$133	Buy
OR16087	250mg	$15	Buy
OR16087	1g	$19	Buy
J11466	25mg	$39	Buy

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Chemical Properties,Uses,Production

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.

Synthesis

3- [(Aminoiminomethyl)amino] -4-methyl-benzoic acid methyl ester mononitrate (10 g),3-(Dimethylamino)-1-(pyridine-3-yl)prop-2-en-1-one (7.3 g), sodium hydroxide (1.7 g) was added to 1-butanol (100 mL) in a round bottom flask under nitrogen atmosphere. The reaction mass was heated to reflux temperature and stirred for 12 hours. Then the reaction mass was cooled to 25-35°C, and iN sodium hydroxide solution (1.5 g in 37 mL of DM water) was added to it throughout 20 mm. The reaction mass was heated to reflux temperature (120-125°C) and then cooled to 25-35°C. Hydrochloric acid was added to the reaction mass at 25-35°C and stirred for an hour. The material formed was filtered, washed with DM water and then dried under vacuum at 50-55°C to provide 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (8.7 g).

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid synthesis

Synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid from 3-Amino-4-methylbenzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester Methyl 3-guanidino-4-Methylbenzoate Imatinib Impurity Methyl 3-amino-4-methylbenzoate 3-Amino-4-methylbenzoic acid

3-[(aMinoiMinoMethyl)aMino]-4-Methylbenzoic acid Methyl ester Mononitrate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Ethyl 3-Amino-4-methylbenzoate 3-Acetylpyridine

3-Bromo-4-methylbenzoic acid

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Preparation Products

Nilotinib

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Suppliers

Global( 256)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868	jennysun@yzqyyykj.com	China	64	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58

Supplier	Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-20	4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2023-03-12	4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0	US $0.00 / kg	1kg	98.0%min	100kg	LY Global chemicals co.,ltd .
2022-08-24	4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid 641569-94-0	US $20.00 / kg	1kg	99%	5000 Ton	Hebei Duling International Trade Co. LTD

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
US $0.00 / kg
98.0%min
LY Global chemicals co.,ltd .

4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid
641569-94-0
US $20.00 / kg
99%
Hebei Duling International Trade Co. LTD

641569-94-0(4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid)Related Search:

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid 2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine Nilotinib Intemediate 2 4-Methyl-3-((4-(pyridin-3-yl) Nilotinib EP Impurity D Nilotinib Carboxylic Acid Impurity -3-((4-(pyridin-3-yL 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(For export only) Nilotinib EP Impurity D/B 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic aci... 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci Nilotinib Impurity 6 (Nilotinib EP Impurity D) Nilotinib Hydrochloride Monohydrate EP Impurity D 4-Methyl-3-[[4-G-pyridinyl)-2-pyrimidinyl]amino] benzoic acid 641569-94-0 641589-94-0