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Trimetazidine dihydrochloride

Description References
Trimetazidine dihydrochloride
Trimetazidine dihydrochloride structure
CAS No.
13171-25-0
Chemical Name:
Trimetazidine dihydrochloride
Synonyms
s4004;Takkmint;vastarel;kyurinett;Yoshimilon;Vastarel F;Youmetazine;Trimetazidine 3HCl;TRIMETAZIDINE 2HCL;TRIMETAZIDINE DI HCL
CBNumber:
CB6176226
Molecular Formula:
C14H24Cl2N2O3
Formula Weight:
339.26
MOL File:
13171-25-0.mol

Trimetazidine dihydrochloride Properties

Melting point:
231-235 °C(lit.)
storage temp. 
Refrigerator
solubility 
Freely soluble in water, sparingly soluble in alcohol.
form 
neat
Merck 
14,9705
CAS DataBase Reference
13171-25-0(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  TM2976100
HazardClass  IRRITANT
HS Code  29339900
Toxicity LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Trimetazidine dihydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 653322 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride 97% 13171-25-0 10g $93.3 2018-11-13 Buy
Sigma-Aldrich 653322 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride 97% 13171-25-0 25g $168 2018-11-13 Buy
Cayman Chemical 18165 Trimetazidine (hydrochloride) ≥98% 13171-25-0 10mg $29 2018-11-13 Buy
Cayman Chemical 18165 Trimetazidine (hydrochloride) ≥98% 13171-25-0 25mg $58 2018-11-13 Buy
Sigma-Aldrich Y0000093 Trimetazidine for system suitability European Pharmacopoeia (EP) Reference Standard 13171-25-0 y0000093 $179 2018-11-23 Buy

Trimetazidine dihydrochloride Chemical Properties,Uses,Production

Description

Trimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.

References

Fragasso, G, et al. "A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. " Journal of the American College of Cardiology 48.5 (2006):992.
Tuunanen, H, et al. "Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy."Circulation 118.12(2008):1250.
Kantor, P. F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase."Circulation Research 86.5(2000):580.
Stanley, W. C., and M. Marzilli. "Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. "Fundamental & Clinical Pharmacology 17.2(2003):133–145.
Kantor, Paul F., et al. "The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase." Circulation research 86.5 (2000): 580-588.

Chemical Properties

Crystalline Solid

Uses

Antianoxic

Uses

Coronary vasodilator. Antianginal

Trimetazidine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Trimetazidine dihydrochloride Suppliers

Global( 199)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21830 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hebei Minshang Biotechnology Co., Ltd
+86-13230167943
cathy@hbminshang.com CHINA 278 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23957 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8267 58

View Lastest Price from Trimetazidine dihydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-22 Trimetazidine dihydrochloride
13171-25-0
US $7.00 / kg 1kg 99% 100KG career henan chemical co

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