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Tetramethylpyrazine

Description Chemical Characteristic Uses Preparation References
Tetramethylpyrazine
Tetramethylpyrazine structure
CAS No.
1124-11-4
Chemical Name:
Tetramethylpyrazine
Synonyms
FEMA 3237;BS Factor;Ligustizine;Ligustrazine;Chuanxingzine;TETRAPYRAZINE;FEMA NUMBER 3237;Tetramethylpyrazin;TETRAMETHYLPYRAZINE;tetramethyl-pyrazin
CBNumber:
CB6186289
Molecular Formula:
C8H12N2
Formula Weight:
136.19
MOL File:
1124-11-4.mol

Tetramethylpyrazine Properties

Melting point:
77-80 °C(lit.)
Boiling point:
190 °C(lit.)
Density 
1.08
refractive index 
1.5880 (estimate)
FEMA 
3237 | 2,3,5,6-TETRAMETHYLPYRAZINE
Flash point:
128-130°C/200mm
storage temp. 
Store below +30°C.
solubility 
4g/l
form 
neat
Water Solubility 
Soluble in water (4 g/L at 20°C).
JECFA Number
780
BRN 
113100
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference
1124-11-4(CAS DataBase Reference)
NIST Chemistry Reference
Pyrazine, tetramethyl-(1124-11-4)
EPA Substance Registry System
Pyrazine, tetramethyl-(1124-11-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41-36/37/38
Safety Statements  26-39-24/25-37/39-36
WGK Germany  3
RTECS  UQ3905000
TSCA  Yes
HS Code  29339990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Tetramethylpyrazine price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 183938 2,3,5,6-Tetramethylpyrazine 98% 1124-11-4 100g $139 2018-11-13 Buy
Sigma-Aldrich 183938 2,3,5,6-Tetramethylpyrazine 98% 1124-11-4 25g $49.7 2018-11-13 Buy
TCI Chemical T0972 2,3,5,6-Tetramethylpyrazine >98.0%(GC)(T) 1124-11-4 25g $26 2018-11-22 Buy
Alfa Aesar A18279 2,3,5,6-Tetramethylpyrazine, 98+% 1124-11-4 25g $38.7 2018-11-13 Buy
Alfa Aesar A18279 2,3,5,6-Tetramethylpyrazine, 98+% 1124-11-4 100g $127 2018-11-13 Buy

Tetramethylpyrazine Chemical Properties,Uses,Production

Description

Tetramethylpyrazine (TMP) is a kind of alkaloids identified in Ligusticum wallichii FRANCH. It has various kinds of medical applications. It has long been used in China for the treatment of cardiovascular problems. It also has antiinflammatory and analgesic effect. It can be used for the treatment of diabetic peripheral neuropathy. Through effectively penetrating across the blood-brain barrier, it can exert its neuroprotection function which is useful for the treatment of ischemic brain injury. Moreover, it can eliminate superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.

Chemical Characteristic

White crystal or powder. With aroma of beef and heated lard and fermented soybean flavor. It smells chocolate flavor when diluted to 20mg/kg. Boiling point is 190℃. Melting point is between 84 and 86℃. Soluble in ethanol, most non-volatile oils and propylene glycol, slightly soluble in water.
Natural products exist in guava, roast beef, cocoa, coffee, shrimp and so on.

Uses

Preparation

References

TH Tsai, CC Liang. International Journal of Pharmaceutics, 216. 1-2 (2001)
WU, Zhi-youg, et al. Chinese Journal of Experimental Traditional Medical Formulae 14 (2012): 085.
Ozaki, Yukihiro. Chemical and pharmaceutical bulletin 40.4 (1992): 954-956.
Kao, Tsung-Kuei, et al. Neurochemistry international 48.3 (2006): 166-176.
Zhang, Zhaohui, et al. Life sciences 72.22 (2003): 2465-2472.

Chemical Properties

white crystals or powder

Uses

Usually used in research and treatment of multiple disorders.

Definition

ChEBI: A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.

Tetramethylpyrazine Preparation Products And Raw materials

Raw materials

Preparation Products


Tetramethylpyrazine Suppliers

Global( 331)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Liaoning Benyuan Pharmaceutical Co., Ltd
024-45627555
024-45627566 sales@benyuanpharm.com China 62 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22084 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20763 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32607 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 300 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6402 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 617 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 468 58

View Lastest Price from Tetramethylpyrazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-28 Tetramethylpyrazine
1124-11-4
US $100.00 / KG 25KG 98% 1000KG career henan chemical co

Tetramethylpyrazine Spectrum


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