ASP-ARG-VAL-TYR-ILE-HIS-PRO
- CAS No.
- 51833-78-4
- Chemical Name:
- ASP-ARG-VAL-TYR-ILE-HIS-PRO
- Synonyms
- A779;DRVYIHP;Ang-(1-7);Merotocin;Talfirastide;DRVYIH{D-Ala};H2N-DRVYIHP-OH;angiotension 1-7;angiotensinii(1-7;ANGIOTENSIN (1-7)
- CBNumber:
- CB6196808
- Molecular Formula:
- C41H62N12O11
- Molecular Weight:
- 899
- MDL Number:
- MFCD00153513
- MOL File:
- 51833-78-4.mol
| Melting point | >202°C (dec.) |
|---|---|
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) |
| form | powder |
| pka | 3.29±0.20(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble to 1 mg/ml in water |
| EWG's Food Scores | 1 |
| FDA UNII | IJ3FUK8MOF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P403+P233-P405-P501 |
| WGK Germany | 3 |
ASP-ARG-VAL-TYR-ILE-HIS-PRO price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9202 | Angiotensin Fragment 1-7 acetate salt hydrate ≥90% (HPLC), powder | 51833-78-4 | 1mg | $75.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | A9202 | Angiotensin Fragment 1-7 acetate salt hydrate ≥90% (HPLC), powder | 51833-78-4 | 5mg | $281 | 2024-03-01 | Buy |
| Tocris | 1562 | Angiotensin(1-7) | 51833-78-4 | 1 | $75 | 2021-12-16 | Buy |
| Tocris | 5937 | A779 | 51833-78-4 | 5 | $86 | 2021-12-16 | Buy |
| TRC | A637945 | Angiotensin(1-7)xTFAsalt | 51833-78-4 | 10mg | $65 | 2021-12-16 | Buy |
ASP-ARG-VAL-TYR-ILE-HIS-PRO Chemical Properties,Uses,Production
Uses
Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.
Definition
ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.
Biological Activity
ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems.
Biochem/physiol Actions
Angiotensin I metabolite that is an AT2 receptor agonist.
storage
Store at -20°C
References
1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)
ASP-ARG-VAL-TYR-ILE-HIS-PRO Preparation Products And Raw materials
ASP-ARG-VAL-TYR-ILE-HIS-PRO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
View Lastest Price from ASP-ARG-VAL-TYR-ILE-HIS-PRO manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-27 | ASP-ARG-VAL-TYR-ILE-HIS-PRO
51833-78-4
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2020-02-18 | ASP-ARG-VAL-TYR-ILE-HIS-PRO
51833-78-4
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- ASP-ARG-VAL-TYR-ILE-HIS-PRO
51833-78-4
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- ASP-ARG-VAL-TYR-ILE-HIS-PRO
51833-78-4
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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