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ChemicalBook >> CAS DataBase List >>6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Structure
6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid structure
CAS No.
112984-60-8
Chemical Name:
6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
Synonyms
PL-11;NM 394;Panc327;PANC 327;PANC3.27;Panc3_27;Panc-327;Panc 3.27;Panc-3_27;ulifloxacin
CBNumber:
CB6197108
Molecular Formula:
C16H16FN3O3S
Molecular Weight:
349.38
MDL Number:
MFCD00882994
MOL File:
112984-60-8.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:41
Product description Number Pack Size Price
Ulifloxacin U700700 100mg $110
Ulifloxacin U700700 500mg $475
Ulifloxacin 62521 100mg $620
6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 95+% 093686 1g $706
6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID 95.00% HCH0013737 5G $1899.98
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6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Properties

Melting point 215-218 °C (decomp)
Boiling point 577.0±50.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka 5.85±0.40(Predicted)
color Pale Yellow to Yellow
CAS DataBase Reference 112984-60-8(CAS DataBase Reference)
FDA UNII C38638H76Y
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC U700700 Ulifloxacin 112984-60-8 100mg $110 2021-12-16 Buy
TRC U700700 Ulifloxacin 112984-60-8 500mg $475 2021-12-16 Buy
Medical Isotopes, Inc. 62521 Ulifloxacin 112984-60-8 100mg $620 2021-12-16 Buy
Matrix Scientific 093686 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 95+% 112984-60-8 1g $706 2021-12-16 Buy
American Custom Chemicals Corporation HCH0013737 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID 95.00% 112984-60-8 5G $1899.98 2021-12-16 Buy
Product number Packaging Price Buy
U700700 100mg $110 Buy
U700700 500mg $475 Buy
62521 100mg $620 Buy
093686 1g $706 Buy
HCH0013737 5G $1899.98 Buy

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

A labelled metabolite of Prulifloxacin (P838885). Ulifloxacin is a new quinolone antibiotic and it is effective against pneumonia.

Uses

A metabolite of Prulifloxacin (P838885). Ulifloxacin is a new quinolone antibiotic and it is effective against pneumonia.

Definition

ChEBI: Ulifloxacin is a member of quinolines.

Biological Activity

Ulifloxacin is an orally available, broad-spectrum fluoroquinolone antibacterial agent. Ulifloxacin is an active metabolite of Prulifloxacin. It potently inhibits bacterial DNA gyrase and topoisomerase IV.

Synthesis

Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate

113028-17-4

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

112984-60-8

The general procedure for the synthesis of 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazolo[3,2-a]quinoline-3-carboxylic acid from ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1,4-dihydro-[1,3]thiazolo[3,2-a]quinoline-3-carboxylate was as follows: 1. ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazolo[3,2-a]quinoline-3-carboxylate (100 g, 0.265 mol) was dissolved in water (600 ml) at 25-30 °C with stirring. 2. potassium hydroxide solution (50 g of potassium hydroxide flakes dissolved in 200 ml of water) was slowly added to this solution. 3. the reaction mixture is heated to 80-85°C and stirred at this temperature for 1 hour. 4. After completion of the reaction, the reaction mixture was cooled down to 25-30 °C. The reaction mixture was then cooled down to 25-30 °C. 5. The pH of the reaction mixture was adjusted to 6.5-7.0 using a 1:1 aqueous solution of acetic acid. 6. The reaction mixture was stirred at room temperature for 1 hour to allow the product to fully precipitate. 7. The precipitated solid was collected by filtration and washed with distilled water (2 x 100 mL). 8. The solid was slurried in methanol (300 ml) at 25-30 °C for 1 h. The reaction mixture was stirred for 1 h at room temperature. 9. After filtration, the solid was washed with methanol (2 x 50 ml). 10. The product was dried under vacuum at 70-75 °C to afford 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (90 g, 97% yield, 96% HPLC purity).

References

[1] Patent: WO2012/1357, 2012, A1. Location in patent: Page/Page column 22
[2] Patent: CN103113392, 2016, B. Location in patent: Paragraph 0024; 0037; 0038; 0039
[3] Patent: CN107383069, 2017, A. Location in patent: Paragraph 0063; 0064
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 25, p. 4727 - 4738
[5] Patent: WO2009/93268, 2009, A1. Location in patent: Page/Page column 15

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Acetic acid

Preparation Products

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Suppliers

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8770 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21615 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15126 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9644 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
ANHUI WITOP BIOTECH CO., LTD 		58
AFINE CHEMICALS LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
changzhou huayang technology co., ltd 		58

View Lastest Price from 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid pictures 2025-11-10 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
112984-60-8
 US $25.00 / KG 100KG 99.5% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid pictures 2019-07-06 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
112984-60-8
 US $500.00 / KG 100G 98% 10KG,20KG Career Henan Chemical Co

112984-60-8(6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid)Related Search:

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Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Prulifloxacin 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

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6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto 6-Fluoro-1-Methyl-4-oxo-7- 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxy 6-Fluoro-1-Methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 6-fluoro-1-Methyl-4-oxo- 7-(1-piperazinyl)-4H-(1,3) S,N-containing heterocyclic bi- (3,2-a) quinoline-3-carboxylic acid PL-11 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic PRULIFLOXACIN INTERMEDIATE 3 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID 6-FLUORO-1-METHYL-4-OXO-7-PIPERAZIN-1-YL-4H-2-THIA-8B-AZA-CYCLOBUTA[A] NAPHTHALENE-3-CARBOXYLIC ACID 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-4H-(1,3)-THIAZETO(3,2-A)QUINOLINE-3-CAR 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)- 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-1H,4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto(3,2-a)quinoline-3-carboxylic acid cas:(intermediate of prulifloxacin) 6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)-HIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID 6-FLUORO-7-PIPERAZINE-1-METHYL-4-OXY-[1,3]THIOAZACYCLIC[3,2-A]-QUINOLINE-3-CARBOXYLIC ACID NM 394 6-Fluoro-1-Methyl-4-Oxo-7-(1-Piperazinyl)-4H-(1,3)-Thiazeto(3,2-Alpha)Quinoline-3-Carboxylic Acid 6-Fluoro-1-methyl-7-(1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid ulifloxacin Prulifloxacin Intermediate PL-11 6-Fluro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto(3,2-a)quinoline-3-carboxylic Acid PL-11 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H- (1,3)-hiazeto(3,2-a)quinoline-3-carboxylic acid 6-Fluoro-1-Methyl-4-Oxo-7-(1-Piperazinyl)-4H-[1,3]Thiazeto[3,2-A]Quinoline-3-Carboxylic Acid Pl-11 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Prulifloxacin intermediate III Panc 03.27 Cells Line Panc 3.27 PANC 327 PANC3.27 Panc3_27 Panc-3_27 Panc327 Panc-327 112984-60-8 C16H8D8FN3O3S C16H16FN3O3S C16H16N3O3FS PRULIFLOXACIN (intermediate of prulifloxacin) Aromatics Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Sulfur & Selenium Compounds Isotope Labelled Compounds API intermediates Other Products