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Chloroacetyl chloride

CAS No.
79-04-9
Chemical Name:
Chloroacetyl chloride
Synonyms
2-CHLOROACETYL CHLORIDE;chloroacetyl;Chloroacetic ahloride;CHLORACETYL CHLORIDE;Chloroacetic chloride;alpha-Chloroacetyl chloride;Chloroac;CH2ClCOCl;oroacetyL;chloracetyl
CBNumber:
CB6202877
Molecular Formula:
C2H2Cl2O
Molecular Weight:
112.94
MDL Number:
MFCD00000725
MOL File:
79-04-9.mol
Last updated:2024-03-14 15:18:27

Chloroacetyl chloride Properties

Melting point −22 °C(lit.)
Boiling point 105-106 °C(lit.)
Density 1.419 g/mL at 20 °C
vapor density 3.9 (vs air)
vapor pressure 60 mm Hg ( 41.5 °C)
refractive index n20/D 1.453(lit.)
Flash point >100°C
storage temp. Store at RT.
solubility Miscible with ethyl ether, acetone, benzene and carbon tetrachloride.
form Liquid
color Clear colorless to slightly yellow
Odor strong pungent odor
Water Solubility reacts
FreezingPoint -22.5℃
Sensitive Moisture Sensitive
Merck 14,2067
BRN 605439
Exposure limits ACGIH: TWA 0.05 ppm; STEL 0.15 ppm (Skin)
NIOSH: IDLH 1.3 ppm; TWA 0.05 ppm(0.2 mg/m3)
Stability Stable. Incompatible with strong bases, alcohols, strong oxidizing agents. May react violently on exposure to water or moisture.
CAS DataBase Reference 79-04-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII K5UML06YUO
NIST Chemistry Reference Acetyl chloride, chloro-(79-04-9)
EPA Substance Registry System Chloroacetyl chloride (79-04-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H314-H372-H400
Precautionary statements  P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P314
Hazard Codes  T,C,N
Risk Statements  14-23/24/25-35-48/23-50-29
Safety Statements  9-26-36/37/39-45-61-7/8
RIDADR  UN 1752 6.1/PG 1
WGK Germany  3
RTECS  AO6475000
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29159000
IDLA 1.3 ppm (6 mg/m3)
NFPA 704
0
3 1

Chloroacetyl chloride price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 22880 Chloroacetyl chloride purum, ≥99.0% (GC) 79-04-9 100ML $39 2023-06-20 Buy
Sigma-Aldrich 22880 Chloroacetyl chloride purum, ≥99.0% (GC) 79-04-9 500ML $103 2023-06-20 Buy
Sigma-Aldrich 22880 Chloroacetyl chloride purum, ≥99.0% (GC) 79-04-9 1L $180 2023-06-20 Buy
Sigma-Aldrich 104493 Chloroacetyl chloride 98% 79-04-9 5G $29.9 2023-06-20 Buy
Sigma-Aldrich 104493 Chloroacetyl chloride 98% 79-04-9 100G $36.4 2023-06-20 Buy
Product number Packaging Price Buy
22880 100ML $39 Buy
22880 500ML $103 Buy
22880 1L $180 Buy
104493 5G $29.9 Buy
104493 100G $36.4 Buy

Chloroacetyl chloride Chemical Properties,Uses,Production

Description

Chloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.Molecular weight=112.95; Specific gravity (H2O:1) 51.42; Boiling point=105℃; Freezing/Meltingpoint=222℃; Vapor pressure=19 mmHg at 20℃.NFPA 704 M Rating System: Health 3, Flammability 1,Reactivity 1 . Reacts violently with water.

Chemical Properties

Chloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.

Uses

In the synthesis of organic compounds.

Uses

Intermediate in manufacture of chloroacetophenone and various other chemicals

Uses

Chloroacetyl chloride is an intermediate in the production of alachlor and butachlor. It is used to prepare phenacyl chloride through Friedel-Crafts acylation of benzene.

Application

Chloroacetyl chloride can be used for chloroacetylation and chemical modification of poly(glycidyl methacrylate).
Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Chloroacetyl chloride was used in the synthesis of some novel quinoline derivatives having antileishmanial activity.

Preparation

Chloroacetyl chloride is usually manufactured from chloroacetic acid by reaction with phosphorus trichloride, thionyl chloride, sulfuryl chloride, or phosgene. It is also obtained by chlorination of acetyl chloride in the presence of stronger aliphatic acids, preferably chloroacetic acids, or from sodium chloroacetate and the usual chlorinating agents.
Koenig G et al; Chloroacetic Acids. Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: October 15, 2012

Definition

Chloroacetyl chloride is classified as an acyl halide. It is a colorless to light yellow liquid with a strong, pungent odor. This compound is highly toxic when inhaled and can corrode both metal surfaces and tissues.

General Description

A colorless to light yellow liquid with a very pungent odor. Very toxic by inhalation. Corrosive to metals and tissue.

Reactivity Profile

Chloroacetyl chloride reacts rapidly with water. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Irritant to eyes, corrosive to skin. Upper respiratory tract irritant.

Health Hazard

Inhalation causes severe irritation of upper respiratory system. External contact causes severe irritation of eyes and skin. Ingestion causes severe irritation of mouth and stomach.

Safety Profile

Poison by ingestion and intravenous routes. Mildly toxic by inhalation. Corrosive. A lachrymator. When heated to decomposition it emits toxic fumes of Cl-.

Potential Exposure

Highly toxic by inhalation. Chloroacetyl chloride is used in the manufacture of acetophenone. It is used in the manufacture of a number of pesticides including: alachlor, allidochlor, butachlor, dimethachlor, formothion, mecarbam, metolachlor, propachlor. It is also used in the manufacture of pharmaceuticals, such as chlordiazepoxide hydrochloride, diazepam, lidocaine, mianserin.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting. Medical observation isrecommended for 24-48 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consideradministering a corticosteroid spray.

Carcinogenicity

Chloroacetyl chloride was not genotoxic in a number of assays.

storage

Chloroacetyl chloride must carry a“CORROSIVE” label. It falls in Hazard Class 8 andPacking Group I.

Shipping

UN1752 Chloroacetyl chloride, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive material, Inhalation Hazard Zone B.

Incompatibilities

Reacts violently with water, steamforming chloroacetic acid and hydrogen chloride gas. Reacts with alcohols, powdered metals; sodium amide; combustibles; and many organics, causing toxic fumes, fire, and explosion hazard. On contact with air it emits corrosive gas. Decomposes when heated forming phosgene gas. Corrosive to metals.

Waste Disposal

It may be discharged into sodium bicarbonate solution, then flushed to the sewer with water.

75-36-5
79-04-9
Synthesis of Chloroacetyl chloride from Acetyl chloride
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View Lastest Price from Chloroacetyl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chloroacetyl chloride pictures 2024-03-27 Chloroacetyl chloride
79-04-9
US $0.00 / kg/drum 250kg/drum 99% 100000MT Yancheng Green Chemicals Co.,Ltd
Chloroacetyl chloride pictures 2023-11-14 Chloroacetyl chloride
79-04-9
US $0.00-0.00 / kg 1kg 99% 50000kg Hebei Yibangte Import and Export Co. , Ltd.
Chloroacetyl chloride pictures 2023-07-27 Chloroacetyl chloride
79-04-9
US $1.10 / g 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
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