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2-Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-β-cyclodextrin
2-Hydroxypropyl-β-cyclodextrin structure
CAS No.
128446-35-5
Chemical Name:
2-Hydroxypropyl-β-cyclodextrin
Synonyms
HPBCD/HPCD;HP-beta-CD;)-beta-cycL;CAVASOL(R)W7;Cavasol? W7 HP;Hydroxypropyl Betade;2-Hydroxypropyl-βHydroxypropylbetadex CRS;Hydroxypropyl-b-Cyclodextrin;hydropropyl beta cyclodextrin
CBNumber:
CB6204503
Molecular Formula:
C63H112O42
Formula Weight:
1541.54
MOL File:
128446-35-5.mol

2-Hydroxypropyl-β-cyclodextrin Properties

Melting point:
278 °C (dec.)
refractive index 
125 ° (C=1, H2O)
storage temp. 
room temp
solubility 
H2O: 45 % (w/v)
form 
solution (clear, colorless)
color 
White to slightly yellow
optical activity
[α]26/D +139°, c = 1 in H2O
Water Solubility 
Soluble in water.
InChIKey
ODLHGICHYURWBS-FOSILIAISA-N
EPA Substance Registry System
.beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
RTECS  GU2293332
TSCA  Yes
HS Code  29400090
NFPA 704
1
1 1

2-Hydroxypropyl-β-cyclodextrin price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 332593 (2-Hydroxypropyl)-β-cyclodextrin average Mw ~1,380 128446-35-5 1kg $683 2021-12-16 Buy
Sigma-Aldrich 1329709 Hydroxypropyl betadex United States Pharmacopeia (USP) Reference Standard 128446-35-5 200mg $414 2021-12-16 Buy
TCI Chemical H0979 Hydroxypropyl-β-cyclodextrin 128446-35-5 25g $124 2021-12-16 Buy
TCI Chemical H0979 Hydroxypropyl-β-cyclodextrin 128446-35-5 100g $226 2021-12-16 Buy
Alfa Aesar H31133 (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480 128446-35-5 25g $145 2021-12-16 Buy

2-Hydroxypropyl-β-cyclodextrin Chemical Properties,Uses,Production

Chemical Properties

White to slightly yellow powder

Chemical Properties

Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

Uses

2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.

Uses

enteric coating, sustained release formulations, buccal and transdermal drug delivery

Uses

2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis

Production Methods

Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.

General Description

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.

Pharmaceutical Applications

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

Safety

The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.

storage

Store in well-closed containers.

Regulatory Status

Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

2-Hydroxypropyl-β-cyclodextrin Preparation Products And Raw materials

Raw materials

Preparation Products


2-Hydroxypropyl-β-cyclodextrin Suppliers

Global( 431)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
13562317646
0543 2605568 bob.zhao@cydextrin.com CHINA 46 58
Qingdao kaimoshi biochemical technology co., ltd.
+(86) 571 87700752
+(86) 571 87700752 info@kaimosi.com CHINA 145 58
Hebei Ruiyao Biotechnology Co. Ltd
15532235888 15632182983
031188180881 admin@ruiyaobio.com CHINA 846 58
Hebei Qige Biological Technology Co. Ltd
8618733132031
qige01@hbqige.com CHINA 1322 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
86-27-59524646 info@fortunachem.com CHINA 3073 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15427 58
Dalian Richfortune Chemicals Co., Ltd
0411-84820922
86-411-84821380 sales@richfortunechem.com China 300 57
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55

View Lastest Price from 2-Hydroxypropyl-β-cyclodextrin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-20 2-Hydroxypropyl-β-cyclodextrin
128446-35-5
US $50.00 / g 10g 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2022-01-20 2-Hydroxypropyl-β-cyclodextrin
128446-35-5
US $0.00 / Kg/Drum 1KG 99.9% 100000kg per month Wuhan Mulei New Material Technology Co. Ltd
2022-01-20 2-Hydroxypropyl-β-cyclodextrin
128446-35-5
US $60.00 / KG 1KG 99% 20 tons Hanhong Medicine Technology (Hubei) Co., Ltd.

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