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ANSAMITOCIN P-3

ANSAMITOCIN P-3 structure

CAS No.: 66547-09-9

Chemical Name:: ANSAMITOCIN P-3

Synonyms: ASMP-3;CS-1373;c15003p-3’;Aansamitocin P3;ANSAMITOCIN P-N;Maytansinoid AP-3;antibioticc15003p3’;maytansinolbutyrate;Ansamitocin P-3, >=70%;Ansamitocin P-3 (≥90%)

CBNumber:: CB6205964

Molecular Formula:: C32H43ClN2O9

Molecular Weight:: 635.14

MDL Number:: MFCD01939731

MOL File:: 66547-09-9.mol

Last updated:2023-06-08 09:02:48

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ANSAMITOCIN P-3 Properties

Melting point	182-185℃
Boiling point	837.6±65.0 °C(Predicted)
Density	1.30±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
pka	9.83±0.70(Predicted)
form	White to off-white crystalline solid.
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
EWG's Food Scores	1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Hazard Codes

Risk Statements

20/22-36/37/38

Safety Statements

26-36

WGK Germany

RTECS

OQ2293000

NFPA 704

	0
3		0

ANSAMITOCIN P-3 price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	20538	Ansamitocin P-3 ≥85%	66547-09-9	1mg	$68	2024-03-01	Buy
Cayman Chemical	20538	Ansamitocin P-3 ≥85%	66547-09-9	5mg	$169	2024-03-01	Buy
Cayman Chemical	20538	Ansamitocin P-3 ≥85%	66547-09-9	10mg	$302	2024-03-01	Buy
Cayman Chemical	20538	Ansamitocin P-3 ≥85%	66547-09-9	25mg	$669	2024-03-01	Buy
TRC	A678300	AnsamitocinP-3’(≥90%)	66547-09-9	25mg	$195	2021-12-16	Buy

Product number	Packaging	Price	Buy
20538	1mg	$68	Buy
20538	5mg	$169	Buy
20538	10mg	$302	Buy
20538	25mg	$669	Buy
A678300	25mg	$195	Buy

ANSAMITOCIN P-3 Chemical Properties,Uses,Production

Description

Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (K_d = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.

Uses

Ansamitocin P-3’ is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic.

References

1) Li et al (1992) Binding selectivity of rhizoxin, phomopsin A, vinblastine and ansamitocin P-3 to fungal tubulins: differential interactions of thes antimitotic agents with brain and fungal tubulins; Biochem. Biophys. Res. Commun., 187 722 2) Venghateri et al. (2013) Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding Tubulin at the Vinblastine Site; PLoS ONE 8 e75182 3) Suwanborirux et al. (1990) Ansamitocin P-3, a maytansinoid, from claopodium crispifolium and anomodo attenuates or associated actinomycetes; Experientia, 46 117 4) Ootsu et al. (1980) Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro; Cancer Res. 40 1707

ANSAMITOCIN P-3 Preparation Products And Raw materials

Raw materials

Preparation Products

ANSAMITOCIN P-3 Suppliers

Global( 178)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
AB PharmaTech,LLC	323-480-4688		United States	989	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Beijing Yibai Biotechnology Co., Ltd	0086-182-6772-3597	sales04@yibaibiotech.com	CHINA	419	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
Shenzhen Nexconn Pharmatechs Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
Beijing Yibai Biotechnology Co., Ltd	58

View Lastest Price from ANSAMITOCIN P-3 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-08-30	ANSAMITOCIN P-3 66547-09-9	US $700.00-650.00 / g	1g	99%	25kg/ month	Wuhan Qiami Technology Co., Ltd
2021-12-14	Ansamitocin P-3 66547-09-9	US $10.00 / g/Bag	10g	99	100KG	Wuhan Demeikai Biotechnology Co., Ltd
2021-07-13	Ansamitocin P-3" 66547-09-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

ANSAMITOCIN P-3
66547-09-9
US $700.00-650.00 / g
99%
Wuhan Qiami Technology Co., Ltd

Ansamitocin P-3
66547-09-9
US $10.00 / g/Bag
99
Wuhan Demeikai Biotechnology Co., Ltd

Ansamitocin P-3"
66547-09-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

ANSAMITOCIN P-3 Spectrum

ANSAMITOCIN P-3(66547-09-9)MS

66547-09-9(ANSAMITOCIN P-3)Related Search:

ansamitocin P-3 NOCODAZOLE MYOSEVERIN 2-CHLORO-5-METHYLPHENOL Phenol, 3-amino-2-chloro-

8,10-DODECADIEN-1-OL 2-Chloro-3-methoxyaniline ANSAMITOCIN P-3 3-[(3-N,N-DIMETHYLAMINO)PHENYL]-1-PROPENE (S)-2-Methyl Glycidol

4-(3-METHOXY-PHENYLAMINO)-BUTAN-1-OL Acetamide, N-(2-chloro-3-methoxyphenyl)- 4-chloro-3-methoxytoluene 2-CHLORO-5-ETHYLPHENOL hedonal

(S)-3,4-DIHYDROXYBUTYRAMIDE RARECHEM AN KD 0246 Maytansine, O3-acetyl-O3-de2-(acetylmethylamino)-1-oxopropyl-22-demethyl-

1of4

3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-maytansinbutyrate(ester Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester) Maytansine, o(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup 3)-(1-oxobutyl)- (9ci) Ansamitocin P-3, >=70% Maytansinoid AP-3 ANSAMITOCIN P-N Aansamitocin P3 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansinebutyrate(ester) antibioticc15003p3’ c15003p-3’ maytansine,o(sup3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup3)-(1-oxobut maytansinolbutyrate ASMP-3 ANSAMITOCIN P-3, ACTINOSYNNEMA PRETIOSUM ANSAMITOCIN P-3 FROM ACTINOSYNNEMAPRETIO SUM Maytansine, 2-de(acetylmethylamino)-2-methyl- Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-O3-(1-oxobutyl)- 3-O-De[2-[acetyl(methyl)amino]-1-oxopropyl]-3-O-(1-oxobutyl)maytansine ANTIBIOTIC C 15003P3; MAYTANSINOL BUTYRATE; C15003P3 CS-1373 ANTIBIOTIC C 15003P3';MAYTANSINOL BUTYRATE Ansamitocin P-3 (≥90%) Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)- Maytansinol Impurity 1 (Maytansinol Butyrate)(Ansamitocin P-3) TIANFUCHEM--66547-09-9---ANSAMITOCIN P-3 66547-09-9 65547-09-9 C32H43ClN2O9 BioChemical Cell Biology Cell Signaling and Neuroscience Microtobule Inhibitors Cytoskeleton and Extracellular Matrix Inhibitors Cell Signaling and Neuroscience Cytoskeleton and Extracellular Matrix Microtobule Inhibitors Microtobule Inhibitors Cell Signaling and Neuroscience Cytoskeleton and Extracellular Matrix