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Madecassoside

Madecassoside Structure
Madecassoside structure
CAS No.
34540-22-2
Chemical Name:
Madecassoside
Synonyms
RederMic;MADECASSOIDE;MADECASSOSIDE;Asiaticoside A;MADECASSOSIDE(P);Madecassoside-RM;MADECASSOSIDE hplc;Madecassoside (8CI);MADECASSOSIDE WITH HPLC;Madecassoside (Standard)
CBNumber:
CB6210654
Molecular Formula:
C48H78O20
Molecular Weight:
975.12
MDL Number:
MFCD03411893
MOL File:
34540-22-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 16:31:51
Product description Number Pack Size Price
Madecassoside from Centella asiatica ≥95% % (HPLC) M6949 10mg $204
Madecassoside from Centella asiatica ≥95% % (HPLC) M6949 50mg $621
Madecassoside ≥98% 11855 5mg $63
Madecassoside ≥98% 11855 10mg $118
Madecassoside ≥98% 11855 25mg $274
More product size
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Madecassoside Properties

Melting point 220-223 °C
Boiling point 1043.6±65.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: soluble1mg/mL, clear, colorless
pka 12.50±0.70(Predicted)
form powder
color white to off-white
Water Solubility H2O: 1mg/mL, clear, colorless
Stability Hygroscopic
Major Application metabolomics
vitamins, nutraceuticals, and natural products
Cosmetics Ingredients Functions ANTIOXIDANT
SKIN CONDITIONING
InChIKey BNMGUJRJUUDLHW-CIZDPPTDSA-N
SMILES O1C(C(C(C(C1C)O)O)O)OC2C(OC(C(C2O)O)OCC3OC(C(C(C3O)O)O)OC(=O)C54C(C(C(CC5)C)C)C6=CCC7C8(C(C(CC7(C6(CC4)C)C)O)C(C(C(C8)O)O)(CO)C)C)CO
LogP -1.338 (est)
EWG's Food Scores 1
FDA UNII CQ2F5O6YIY
UNSPSC Code 41116107
NACRES NA.25

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
RTECS  YU9555000
HS Code  29389090
Storage Class 11 - Combustible Solids

Madecassoside price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M6949 Madecassoside from Centella asiatica ≥95% % (HPLC) 34540-22-2 10mg $204 2026-04-30 Buy
Sigma-Aldrich M6949 Madecassoside from Centella asiatica ≥95% % (HPLC) 34540-22-2 50mg $621 2026-04-30 Buy
Cayman Chemical 11855 Madecassoside ≥98% 34540-22-2 5mg $63 2026-04-30 Buy
Cayman Chemical 11855 Madecassoside ≥98% 34540-22-2 10mg $118 2026-04-30 Buy
Cayman Chemical 11855 Madecassoside ≥98% 34540-22-2 25mg $274 2026-04-30 Buy
Product number Packaging Price Buy
M6949 10mg $204 Buy
M6949 50mg $621 Buy
11855 5mg $63 Buy
11855 10mg $118 Buy
11855 25mg $274 Buy

Madecassoside Chemical Properties,Uses,Production

Description

Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.

Chemical Properties

Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)

Uses

Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.

Definition

ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.

benefits

Madecassoside is a key bioactive compound found in Centella asiatica extract and is widely used in skincare products. Madecassoside promotes wound healing and reduces the apoptosis of keratinocytes following UVB radiation damage. It offers benefits such as soothing the skin after sun exposure and strengthening the skin's moisture barrier[2].

Biological Functions

Madecassoside, a triterpenoid saponin compound mainly isolated from the gotu kola herb (Centella asiatica), shows an extensive range of biological activities, including antiapoptotic, antioxidant, anti-inflammatory, moisturizing, neuroprotective, and wound healing effects. It has been highly used in the management of eczema, skin wounds, and other diseases[3].

Mechanism of action

Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].

References

[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.
[2] Tadhi Sucharitakul. (2026). <i>Centella asiatica</i> phytochemical Madecassoside enhances skin wound healing and protects against UVB-induced keratinocyte damage. Tissue Barriers, 2532229. https://doi.org/10.1080/21688370.2025.2532229
[3] Muhammad Suhail*, & Pao-Chu Wu*,  &nbsp; (2024). Formulation and In Vitro Assessment of Polymeric pH-Responsive Nanogels of Chitosan for Sustained Delivery of Madecassoside. ACS Omega, 9 17, 19345–19352. https://doi.org/10.1021/acsomega.4c00461

Madecassoside Preparation Products And Raw materials

Raw materials

Preparation Products

Madecassoside Suppliers

Global( 362)Suppliers
Supplier Tel Email Country ProdList Advantage
Guilin TECA Ingredient Corp 		+86-7737268729 +86-15507717181 jenny.chen@teca-ingredient.com China 2 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 1287 58
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3995 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 477 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Supplier Advantage
Guilin TECA Ingredient Corp 		58
Shaanxi Pioneer Biotech Co., Ltd .
58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
BINBO BIOLOGICAL CO.,LTD 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58

Related articles

View Lastest Price from Madecassoside manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Madecassoside pictures 2026-05-18 Madecassoside
34540-22-2
 US $0.00 / KG 1KG 99% 500kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Madecassoside pictures 2026-05-11 Madecassoside
34540-22-2
 US $44.00-129.00 / mg 99.85% 10g TargetMol Chemicals Inc.
Madecassoside pictures 2026-03-12 Madecassoside
34540-22-2
 US $1100.00 / kg 1kg 90% 8tons Guilin TECA Ingredient Corp
  • Madecassoside pictures
  • Madecassoside
    34540-22-2
  • US $0.00 / KG
  • 99%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Madecassoside pictures
  • Madecassoside
    34540-22-2
  • US $44.00-129.00 / mg
  • 99.85%
  • TargetMol Chemicals Inc.
  • Madecassoside pictures
  • Madecassoside
    34540-22-2
  • US $1100.00 / kg
  • 90%
  • Guilin TECA Ingredient Corp

Madecassoside Spectrum

Madecassoside(34540-22-2)MSMadecassoside(34540-22-2)1HNMR

34540-22-2(Madecassoside)Related Search:

Asiaticoside Total Of Triterpenes Centella asiatica extract METHYL 13-METHYLTETRADECANOATE 1,12-OCTADECANEDIOL
isobutoxypropanol 6-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE isohexadecanoic acid 2-Ethyl-1,3-hexanediol MONOLAURIN
PROPYLENE GLYCOL BUTYL ETHER 15-HYDROXYPENTADECANOIC ACID Isopropyl-cyclohexanecarboxylic acid METHYL 15-HYDROXYPENTADECANOATE N-PENTADECANOIC ACID ETHYL ESTER
ETHYL 2,2-DIETHYLBUTYRATE 1-Octanoyl-rac-glycerol 1,3-DIISOPROPYLCYCLOHEXANE

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MADECASSOIDE MADECASSOSIDE O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate MADECASSOSIDE(P) MADECASSOSIDE hplc Asiaticoside A glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- Urs-12-en-28-oicacid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D- 2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester RederMic MADECASSOSIDE WITH HPLC Madecassoside, froM Centella asiatica Madecassoside, 98%, from Centella asiatica Madecassoside, 98%, from Centella asiatica (L.) Urb. Madecassoside (Asiaticoside A) Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- Madecassoside (8CI) (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate Centella Asiatica Extract Madecassoside Madecassoside-RM Madecassoside from Centella asiatica Madecassoside (Standard) 34540-22-2 C48H78O20 Inhibitors The group of Asiaticoside chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Saponins