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Palonosetron

Palonosetron Structure
Palonosetron structure
CAS No.
149653-99-6
Chemical Name:
Palonosetron
Synonyms
CID 148211;Palonosetron USP/EP/BP;(R)-2-((R)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de] isoquinolin-1-one;[r-(r*,r*)]-2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1h-benz[de]isoquinolin-1-one;1H-Benz[de]isoquinolin-1-one, 2-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aR)-
CBNumber:
CB62131052
Molecular Formula:
C19H24N2O
Molecular Weight:
296.41
MDL Number:
MOL File:
149653-99-6.mol
MSDS File:
SDS
Last updated:2023-03-13 11:54:02
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Palonosetron Properties

Boiling point 470.4±45.0 °C(Predicted)
Density 1.24
pka 9.77±0.33(Predicted)
FDA UNII 5D06587D6R

Palonosetron Chemical Properties,Uses,Production

Indications

Palonosetron is approved by the US FDA for acute and delayed CINV and PONV.

Biological Activity

Palonosetron is a highly selective, high-affinity 5-HT3 receptor antagonist. Due to its structural difference from the first-generation 5-HT3 receptor antagonists, palonosetron has an affinity for the 5-HT3 receptor at least 30 times that of other similar drugs.

in vitro

Palonosetron is neither an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1 and CYP3A4/5 (CYP2C19 not studied) nor does it induce the activity of CYP1A2, CYP2D6 or CYP3A4/5.

Palonosetron Preparation Products And Raw materials

Raw materials

Preparation Products

Palonosetron Suppliers

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20356 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Henan Allgreen Chemical Co.,LTD 		+86-37155567971 +86-13633837469 info@allgreenchem.com China 5986 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33349 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6011 61
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CD Chemical Group Limited 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Henan Allgreen Chemical Co.,LTD 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Chembest Research Laboratories Limited 61

View Lastest Price from Palonosetron manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Palonosetron USP/EP/BP pictures 2021-07-10 Palonosetron USP/EP/BP
149653-99-6
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

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[r-(r*,r*)]-2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1h-benz[de]isoquinolin-1-one CID 148211 1H-Benz[de]isoquinolin-1-one, 2-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aR)- Palonosetron USP/EP/BP (R)-2-((R)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de] isoquinolin-1-one 149653-99-6