ChemicalBook >> CAS DataBase List >>R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride structure

CAS No.: 125941-87-9

Chemical Name:: R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

Synonyms: R(+)-SCH-23390;SCH 23390(HCI);SCH 23390 hydrochlor;SCH 23390 HYDROCHLORIDE;SCH 23390 hydrochloride NEW;(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride

CBNumber:: CB62131148

Molecular Formula:: C17H18ClNOHCl

Molecular Weight:: 324.24

MDL Number:: MFCD00069249

MOL File:: 125941-87-9.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Properties

alpha	+27～+31°(D/20℃)(c=0.5,DMF)
storage temp.	protect from light
solubility	H2O: >5mg/mL
form	solid
color	white
optical activity	[α]/D +32.1°, c = 1 in DMF(lit.)
FDA UNII	4S8T3E2F4Z
EPA Substance Registry System	(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)

SAFETY

Risk and Safety Statements

WGK Germany	3

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D054	R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid	125941-87-9	5mg	$115	2024-03-01	Buy
Sigma-Aldrich	D054	R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid	125941-87-9	10mg	$178	2024-03-01	Buy
Sigma-Aldrich	5.05723	SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem	125941-87-9	10MG	$172	2023-06-20	Buy
Cayman Chemical	15631	SCH 23390 (hydrochloride) ≥99%	125941-87-9	10mg	$141	2024-03-01	Buy
Cayman Chemical	15631	SCH 23390 (hydrochloride) ≥99%	125941-87-9	50mg	$524	2024-03-01	Buy

Product number	Packaging	Price	Buy
D054	5mg	$115	Buy
D054	10mg	$178	Buy
5.05723	10MG	$172	Buy
15631	10mg	$141	Buy
15631	50mg	$524	Buy

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemical Properties,Uses,Production

Uses

R(+)-SCH-23390 hydrochloride has been used:

for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
as a D1 receptor-selective antagonist for intracranial drug infusions
as an antagonist of D1 receptor to study its effect on learning ability in fish

Uses

A selective dopamine D1 receptor antagonist.

Biological Activity

Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

storage

+4°C (desiccate)

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Suppliers

Global( 78)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky (shanghai) International Co.,Ltd	60

View Lastest Price from R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-14	R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride 125941-87-9	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
125941-87-9
US $9.80 / KG
≥99%
Career Henan Chemical Co

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Spectrum

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride(125941-87-9)¹HNMR

125941-87-9(R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride)Related Search:

SCH772984 6-(p-Nitrophenyl)pyrrolo[2,1-d][1,5]benzothiazepine 5,5-dioxide SCH 58261 2-CHLORO-5-METHYLPHENOL P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE

2-(3-Chlorophenyl)ethylamine 4-Chlorophenethylamine 2-CHLORO-4,5-DIMETHYLPHENOL [2-(3-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

8-CHLORO-2,3,4,5-TETRAHYDRO-5-PHENYL-1H-3-BENZAZEPIN-7-OL-(5R) 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE 2-(4-CHLOROPHENYL)-2-PHENYLETHYLAMINE HYDROCHLORIDE N,N-BIS(2-PHENYLETHYL)AMINE HYDROCHLORIDE [2-(4-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE

N,beta-Dimethylphenethylamine hydrochloride [2-(3-CHLORO-PHENYL)-ETHYL]-ETHYL-AMINE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-OL

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R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE SCH 23390 HYDROCHLORIDE R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride SCH 23390(HCI) (+)-SCH23390 Hydrochloride, 98.0+ % (HPLC) R(+)-SCH-23390 R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE SCH 23390 hydrochloride NEW SCH 23390 hydrochlor (R)-8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrochloride 125941-87-9 Dopamine receptor Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals