P-HYDROXYMETHAMPHETAMINE
- CAS No.
- 370-14-9
- Chemical Name:
- P-HYDROXYMETHAMPHETAMINE
- Synonyms
- epifen;Veritol;varitol;veritain;pulsotyl;prometin;knollh75;foledrin;PHOLDERIN;terapinyl
- CBNumber:
- CB6216212
- Molecular Formula:
- C10H15NO
- Molecular Weight:
- 165.23
- MDL Number:
- MFCD00178702
- MOL File:
- 370-14-9.mol
| Melting point | 162-163° |
|---|---|
| Boiling point | 293.09°C (rough estimate) |
| Density | 1.0203 (rough estimate) |
| refractive index | 1.4820 (estimate) |
| storage temp. | −20°C |
| solubility | Methanol (Slightly) |
| pka | 9.82±0.15(Predicted) |
| FDA UNII | AY28O44JGD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi,T,F |
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-45-36/37-16-7 |
| WGK Germany | 3 |
| RTECS | SL8400000 |
| Toxicity | LD50 parenteral in mouse: 100mg/kg |
P-HYDROXYMETHAMPHETAMINE Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Pholedrine Sulfate, ZYF Pharm Chemical
Uses
An a-adrenergic agonist. Antihypotensive.
Definition
ChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process
100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic Function
Sympathomimetic, Mydriatic, Analeptic, Vasopressor