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Sodium phosphate monobasic

Sodium phosphate monobasic
Sodium phosphate monobasic structure
CAS No.
7558-80-7
Chemical Name:
Sodium phosphate monobasic
Synonyms
Chebi:37585;monosorbxp-4;Monobasic,anhydrous;acidsodiumphosphate;Sodium dihydrogenort;Monosodium phosphate;primarysodiumphosphate;sodiumprimaryphosphate;SODIUMDIHYDROPHOSPHATE;MONOSODIUMMONOPHOSPHATE
CBNumber:
CB6219354
Molecular Formula:
H2NaO4P
Formula Weight:
119.977011
MOL File:
7558-80-7.mol

Sodium phosphate monobasic Properties

Melting point:
<0°C
Boiling point:
100°C
Density 
1.40 g/mL at 20 °C
storage temp. 
Store at RT.
solubility 
H2O: 5 M, clear, colorless
form 
powder
color 
White
PH
4.0 - 4.5 (25℃, 50g/L in water)
pka
(1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
Water Solubility 
Soluble in water. Insoluble in alcohol,ether and chloroform.
λmax
λ: 260 nm Amax: ≤0.025
λ: 280 nm Amax: ≤0.02
Sensitive 
Hygroscopic
Merck 
14,8660
BRN 
3903772
Stability:
Stable. Incompatible with heavy metals, strong acids.
InChIKey
AJPJDKMHJJGVTQ-UHFFFAOYSA-M
CAS DataBase Reference
7558-80-7(CAS DataBase Reference)
EPA Substance Registry System
Phosphoric acid, monosodium salt(7558-80-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38-36
Safety Statements  26-36-39
WGK Germany  1
RTECS  WA1900000
3
TSCA  Yes
HS Code  28352200
Hazardous Substances Data 7558-80-7(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Sodium phosphate monobasic price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 229903 Sodium phosphate monobasic 99.999% trace metals basis 7558-80-7 10g $109 2018-11-13 Buy
Sigma-Aldrich 229903 Sodium phosphate monobasic 99.999% trace metals basis 7558-80-7 100g $489 2018-11-13 Buy
Alfa Aesar 040145 Sodium dihydrogen phosphate, 96% 7558-80-7 1kg $54.3 2018-11-16 Buy
Alfa Aesar 040145 Sodium dihydrogen phosphate, 96% 7558-80-7 250g $35.4 2018-11-16 Buy
Sigma-Aldrich S0751 Sodium phosphate monobasic ReagentPlus , ≥99.0% 7558-80-7 100g $19.1 2018-11-13 Buy

Sodium phosphate monobasic Chemical Properties,Uses,Production

Chemical Properties

White, slightly deliquescent crystals or granules.

Chemical Properties

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Uses

Excipient.

Production Methods

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

Pharmaceutical Applications

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

Safety Profile

Poison by intramuscular route. Mdly toxic by ingestion. A human and experimental eye irritant. When heated to decomposition it emits toxic fumes of POx and Na2O. See also PHOSPHATES.

Safety

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

storage

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

Incompatibilities

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium phosphate monobasic Preparation Products And Raw materials

Raw materials

Preparation Products


Sodium phosphate monobasic Suppliers

Global( 293)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Kolod Food Ingredients Co.,Ltd.
+86-518-85110578 18805133257
+86-518-85110578 sales3257@jskolod.com CHINA 100 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
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Shanghai Zheyan Biotech Co., Ltd.
18017610038
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
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86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 1082 58

View Lastest Price from Sodium phosphate monobasic manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 monosodium phosphate
7558-80-7
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-12-19 Sodium phosphate monobasic
7558-80-7
US $1.00 / kg 1kg 99% 500kg career henan chemical co
2017-08-30 Monosodium Phosphate;Sodium Dihydrogen Phosphate;MSP
7558-80-7
US $20.00 / KG 25KG 98%---103% 200 tons Jiangsu Kolod Food Ingredients Co.,Ltd.

Sodium phosphate monobasic Spectrum


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