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Magnolignan

Magnolignan Structure
Magnolignan structure
CAS No.
20601-85-8
Chemical Name:
Magnolignan
Synonyms
Magnolignan;Magnolignan, ≥98%;Tetrahydromagnolol;Tetrahydromagnolol Exclusive;5,5'-Dipropylbiphenyl-2,2'-diol;5,5'-Dipropyl-2,2'-biphenyldiol;5,5'-Dipropyl-[1,1'-biphenyl]-2,2'-diol;[1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl-;2-Hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl;Magnolignan,metabolite,Inhibitor,inhibit,Tetrahydromagnolol,Magnolol,CB2,GPR55,Cannabinoid Receptor,G protein-coupled receptor 55
CBNumber:
CB62296195
Molecular Formula:
C18H22O2
Molecular Weight:
270.37
MDL Number:
MFCD30542730
MOL File:
20601-85-8.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00
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Magnolignan Properties

Melting point 144.5 °C
Boiling point 165.5-166 °C(Press: 2 Torr)
Density 1.080±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤20mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide
form crystalline solid
pka 9.26±0.43(Predicted)

Magnolignan price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14234 Tetrahydromagnolol ≥98% 20601-85-8 5mg $44 2024-03-01 Buy
Cayman Chemical 14234 Tetrahydromagnolol ≥98% 20601-85-8 10mg $84 2024-03-01 Buy
Cayman Chemical 14234 Tetrahydromagnolol ≥98% 20601-85-8 25mg $172 2024-03-01 Buy
ApexBio Technology C5552 Tetrahydromagnolol 20601-85-8 25mg $194 2021-12-16 Buy
ApexBio Technology C5552 Tetrahydromagnolol 20601-85-8 10mg $92 2021-12-16 Buy
Product number Packaging Price Buy
14234 5mg $44 Buy
14234 10mg $84 Buy
14234 25mg $172 Buy
C5552 25mg $194 Buy
C5552 10mg $92 Buy

Magnolignan Chemical Properties,Uses,Production

Biological Activity

tetrahydromagnolol is a major metabolite of magnolol and acts as a peripheral cb2 receptor agonist. tetrahydromagnolol also acts as an antagonist at gpr55 [1].cannabinoid (cb) receptors belong to the g protein-coupled receptor (gpcr) superfamily and are divided into cb1 and cb2. cb1 activation mediates analgesia, stimulation of appetite, and euphoria, among other effects. cb2 receptor activation results in analgesic and antiinflammatory effects. gpr55, a cb-related orphan receptor, is reported to interact with certain cbs [1].tetrahydromagnolol is a highly selective peripheral cb2 receptor agonist that is 19-fold more potent than magnolol with ec50 and ki values of 0.17 μm and 0.42 μm, respectively. magnolol is a bioactive compound isolated from the bark of magnolia officinalis that is used in asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. magnolol behaved as a partial agonist with selectivity for the cb2 subtype (ec50 = 3.28 μm; ki = 1.44 μm). in β-arrestin translocation assay, tetrahydromagnolol inhibited lpi-induced gpr55 activation with kb value of 13.3 μm [1].

References

[1]. rempel v, fuchs a, hinz s, et al. magnolia extract, magnolol, and metabolites: activation of cannabinoid cb2 receptors and blockade of the related gpr55. acs med chem lett. 2012 nov 14;4(1):41-5.

Magnolignan Preparation Products And Raw materials

Raw materials

Preparation Products

Magnolignan Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Jiangsu shring Biopharma Co., Ltd. 		+8613372282299 sales@shringchem.com China 3545 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+8618829768577 gao490372054@gamil.com China 1250 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3582 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33349 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-19164747840 +86-13119157289 13119157289@163.com China 2971 58
Supplier Advantage
Chengdu Biopurify Phytochemicals Ltd. 		58
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58
Jiangsu shring Biopharma Co., Ltd. 		58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Hebei Miaoyin Technology Co.,Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from Magnolignan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5,5'-Dipropyl-2,2'-biphenyldiol pictures 2020-02-11 5,5'-Dipropyl-2,2'-biphenyldiol
20601-85-8
 US $9.80 / KG 1g ＞98% 20 tons Career Henan Chemical Co

Magnolignan Spectrum

Magnolignan(20601-85-8)1HNMR

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Tetrahydromagnolol Tetrahydromagnolol Exclusive 2-Hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl 5,5'-Dipropylbiphenyl-2,2'-diol Magnolignan [1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl- 5,5'-Dipropyl-2,2'-biphenyldiol 5,5'-Dipropyl-[1,1'-biphenyl]-2,2'-diol Magnolignan, ≥98% Magnolignan,metabolite,Inhibitor,inhibit,Tetrahydromagnolol,Magnolol,CB2,GPR55,Cannabinoid Receptor,G protein-coupled receptor 55 20601-85-8