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Cyclobenzaprine hydrochloride

Cyclobenzaprine hydrochloride Structure
Cyclobenzaprine hydrochloride structure
CAS No.
6202-23-9
Chemical Name:
Cyclobenzaprine hydrochloride
Synonyms
CYCLOBENZAPRINE HCL;flexeril;Flexiba;Lisseril;flexiban;Cyclobezaprine HCl;MK130 hydrochloride;Nortriptyline EP Impurity E;Amitriptyline EP Impurity B;Cyclobenzaprine HCl (MK130)
CBNumber:
CB6238272
Molecular Formula:
C20H22ClN
Molecular Weight:
311.85
MDL Number:
MFCD00079039
MOL File:
6202-23-9.mol
MSDS File:
SDS
Last updated:2024-03-22 21:24:34
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Cyclobenzaprine hydrochloride Properties

Melting point 216-2180C
Flash point 9℃
storage temp. Inert atmosphere,Room Temperature
Water Solubility Completely soluble in water
solubility ≥15.59 mg/mL in DMSO; ≥5.32 mg/mL in EtOH; ≥54.3 mg/mL in H2O
color White to Almost white
λmax 290nm(lit.)
Merck 14,2713
InChIKey VXEAYBOGHINOKW-UHFFFAOYSA-N
CAS DataBase Reference 6202-23-9(CAS DataBase Reference)
FDA UNII 0VE05JYS2P
NCI Drug Dictionary cyclobenzaprine hydrochloride

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H312+H332
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn,T,F
Risk Statements  20/21/22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16-7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HP0875000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29214990
Toxicity LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova)
NFPA 704
3
0 0

Cyclobenzaprine hydrochloride price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4542 Cyclobenzaprine hydrochloride 6202-23-9 1g $165 2024-03-01 Buy
Sigma-Aldrich PHR2797 Cyclobenzaprine Hydrochloride certified reference material, pharmaceutical secondary standard 6202-23-9 400MG $280 2024-03-01 Buy
Sigma-Aldrich C-060 Cyclobenzaprine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 6202-23-9 1mL $38.1 2024-03-01 Buy
TCI Chemical C3157 Cyclobenzaprine Hydrochloride >98.0%(HPLC)(T) 6202-23-9 1g $36 2024-03-01 Buy
TCI Chemical C3157 Cyclobenzaprine Hydrochloride >98.0%(HPLC)(T) 6202-23-9 5g $104 2024-03-01 Buy
Product number Packaging Price Buy
C4542 1g $165 Buy
PHR2797 400MG $280 Buy
C-060 1mL $38.1 Buy
C3157 1g $36 Buy
C3157 5g $104 Buy

Cyclobenzaprine hydrochloride Chemical Properties,Uses,Production

Description

Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties. It has been shown to antagonize muscarinic receptors (Kis = 25, 60, and 6 nM for M1, M2, and M3, respectively), serotonin 5-HT2 receptors (Kis = 56 and 330 nM for 5-HT2C and 5-HT2B, respectively), and histamine H1 receptor (IC50 = 20 nM).

Chemical Properties

Crystalline Solid

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.

Uses

Cyclobenzaprine hydrochloride can be used as a serotonin receptor inhibitor.

Uses

Cyclobenzaprine hydrochloride cam be used as muscle relaxant (skeletal).

Definition

ChEBI: The hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

General Description

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of?noradrenaline. It is used to treat neck,?back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

References

[1]. honda m, nishida t, ono h. tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht2 receptors. european journal of pharmacology, 2003, 458(1): 91-99.
[2]. barnes c d, fung s j, gintautas j. brainstem noradrenergic system depression by cyclobenzaprine. neuropharmacology, 1980, 19(2): 221-224.
[3]. leysen j e. 5-ht2 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 11-26.

Cyclobenzaprine hydrochloride Preparation Products And Raw materials

Raw materials

Hydrochloric acid 3-Chloro-1-(N,N-dimethyl)propylamine

Preparation Products

Cyclobenzaprine hydrochloride Suppliers

Global( 327)Suppliers
Supplier Tel Email Country ProdList Advantage
Guangzhou Tengyue Chemical Co., Ltd. 		+86-86-18148706580 +8618826483838 evan@tyvovo.com China 152 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9641 58
Supplier Advantage
Guangzhou Tengyue Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from Cyclobenzaprine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cyclobenzaprine hydrochloride pictures 2024-03-23 Cyclobenzaprine hydrochloride
6202-23-9
 US $90.00 / kg 1kg 99% Purity (What/sapp: +86 18145728414) 1000 Tons/Month Guangzhou Tengyue Chemical Co., Ltd.
Cyclobenzaprine hydrochloride;Cyclobenzaprine hcl pictures 2021-07-08 Cyclobenzaprine hydrochloride;Cyclobenzaprine hcl
6202-23-9
 US $10.00 / KG 10g 99% 1000kg XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Cyclobenzaprine hydrochloride pictures 2019-07-06 Cyclobenzaprine hydrochloride
6202-23-9
 US $1.00 / KG 1KG 99% 100kg Career Henan Chemical Co

Cyclobenzaprine hydrochloride Spectrum

Cyclobenzaprine hydrochloride(6202-23-9)1HNMR

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3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanaminhydroc 5-(3-dimethylaminopropylidene)-5h-dibenzo-(a,d)cycloheptenehydrochloride CYCLOBENZAPRINEHYDROCHLORIDE,USP Lisseril Proheptatriene hydrochloride Cyclobenzaprine hydrochloride,5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride Cyclobenzaprine Hydrochloride (200 mg) 3-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride 1-PropanaMine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-diMethyl-, hydrochloride (1:1) 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, hydrochloride (1:1) Cyclobenzaprine hydrochloride solution d)cycloheptene-delta(sup5)-gamma-propylamine,n,n-dimethyl-5h-dibenzo(hydr flexiban n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5,gamma)-propylaminehydro proheptatrienmonohydrochloride CYCLOBENZAPRINE HYDROCHLORIDE AMITRITYLINE HYDROCHLORIDE IMP B 5-[3-DIMETHYLAMINOPROPYLIDENE]-DIBENZO[A,E]CYCLOHEPTATRIENE HYDROCHLORIDE 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine Hydrochloride Flexiba 1-Propanamine, 3-(5H-dibenzoa,dcyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride Nortriptyline EP Impurity E Amitriptyline EP Impurity B HCl Cyclobenzaprine hydrochloride, 98%, a peripherally-acting AAAD or DOPA decarboxylase inhibitor Cyclobenzaprine Hydrochloride, Usp 99% Amitriptyline hydrochloride impurity B Cyclobenzaprine Hydrochloride(Flexeril,Yurelax) Amitriptyline EP Impurity B Cyclobenzaprine hydrochloride CRS Cyclobenzaprine Hydrochloride > Amitriptyline EP Impurity B HCl (Nortriptyline EP Impurity E HCl) Cyclobezaprine HCl Amitriptyline EP Impurity B (Cyclobenzaprine) Cyclobenzaprine HCl (MK130) Cyclobenzaprine HydrochlorideQ: What is Cyclobenzaprine Hydrochloride Q: What is the CAS Number of Cyclobenzaprine Hydrochloride Q: What is the storage condition of Cyclobenzaprine Hydrochloride Q: What are the applications of Cyclobenzaprine Hydrochloride Cyclobenzaprine Hydrochloride (1154503) Cyclobenzaprine (hydrochloride) (CRM) Hydrochloride Cyclobenzaprine MK130 hydrochloride flexeril CYCLOBENZAPRINE HCL RSSYY(Perospirone Hydrochloride Hydrate)-1 Amitriptyline Hydrochloride EP Impurity B as Hydrochloride Nortriptyline Hydrochloride EP Impurity E as Hydrochloride Nortriptyline Hydrochloride Impurity E as Hydrochloride Nortriptyline EP Impurity E HCl Nortriptyline EP Impurity E HCl (Amitriptyline EP Impurity B HCl) 6202-23-9 6202-32-9 C20H21NClH C20H22ClN C20H21NHCl Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist. Intermediates & Fine Chemicals Pharmaceuticals FLEXERIL Heterocyclic Compounds