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Sucralfate

Sucralfate
Sucralfate structure
CAS No.
54182-58-0
Chemical Name:
Sucralfate
Synonyms
Keal;Ulcar;Urbal;Sugast;Venter;Citogel;Succosa;Sucrate;Antepsin;carafate
CBNumber:
CB6239042
Molecular Formula:
C11H52Al16O75S8-16
Formula Weight:
2072.71
MOL File:
54182-58-0.mol

Sucralfate Properties

storage temp. 
2-8°C
solubility 
Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
form 
neat
pka
pKa = 0.43 to 1.19(at 25℃)

SAFETY

WGK Germany  2
RTECS  BD0900000
HS Code  29400090
Hazardous Substances Data 54182-58-0(Hazardous Substances Data)

Sucralfate price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S0652 Sucrose octasulfate–aluminum complex 54182-58-0 1g $62.8 2018-11-20 Buy
Sigma-Aldrich S0652 Sucrose octasulfate–aluminum complex 54182-58-0 5g $217 2018-11-20 Buy
Sigma-Aldrich Y0001324 Sucralfate European Pharmacopoeia (EP) Reference Standard 54182-58-0 y0001324 $179 2018-11-23 Buy

Sucralfate Chemical Properties,Uses,Production

Chemical Properties

White Powder

Uses

antineoplastic, antileukemia

Uses

An inhibitor of peptic hydrolysis and stomach acidity. Used as an antiulcerative

Indications

Sucralfate (Carafate) is an aluminum hydroxide–sulfated sucrose complex that is only minimally absorbed from the GI tract. After exposure to gastric acid, the compound becomes negatively charged, creating a viscous adherent complex. This complex is believed to inhibit back-diffusion of H .Other effects are a direct reduction in pepsin activity and a slight rise in tissue prostaglandin levels. Stimulation of a cytoprotection mechanism may therefore assist mucosal healing. The drug has no acid-buffering capacity.

brand name

Carafate (Axcan Scandipharm).

General Description

Sucralfate, 3,4,5,6-tetra-(polyhydroxyaluminum)-α-D-glucopyranosyl sulfate-2,3,4,5-tetra-(polyhydroxyaluminum)-β-D-fructofuranoside sulfate (Carafate), isthe aluminum hydroxide complex of the octasulfate ester ofsucrose. It is practically insoluble in water and soluble instrong acids and bases. It has a pKa value between 0.43 and1.19.
Sucralfate is minimally absorbed from the GI tract by design,and thus exerts its antiulcer effect through local ratherthan systemic action. It has negligible acid-neutralizing orbuffering capacity in therapeutic doses. Although its mechanismof action has not been established, studies suggestthat sucralfate binds preferentially to the ulcer site to form aprotective barrier that prevents exposure of the lesion to acidand pepsin. In addition, it adsorbs pepsin and bile salts.Either would be very desirable modes of action.
The simultaneous administration of sucralfate may reducethe bioavailability of certain agents (e.g., tetracycline, phenytoin,digoxin, or cimetidine). It further recommends restorationof bioavailability by separating administration of theseagents from that of sucralfate by 2 hours. Presumably, sucralfatebinds these agents in the GI tract. The most frequentlyreported adverse reaction to sucralfate is constipation (2.2%).Antacids may be prescribed as needed but should not be takenwithin 0.5 hour before or after sucralfate.

Clinical Use

Sucralfate is frequently used for prophylaxis of stress-induced gastritis in patients in intensive care units. It has also been successfully used in small numbers of patients as a suspension enema to treat radiation proctitis.

Veterinary Drugs and Treatments

Sucralfate has been used in the treatment of oral, esophageal, gastric, and duodenal ulcers. It has also been employed to prevent drug-induced (e.g., aspirin) gastric erosions, but efficacy for this is somewhat sporadic. Sucralfate has been used in human patients with hyperphosphatemia secondary to renal failure and potentially could be useful for this in animals as well.

Sucralfate Preparation Products And Raw materials

Raw materials

Preparation Products


Sucralfate Suppliers

Global( 138)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21840 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366 18018719207
0755-85201366 sales@regentsciences.com China 3412 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5997 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32363 50
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9100 52
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 mkt@spectrumchina.net China 9690 60

View Lastest Price from Sucralfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-20 Sucralfate
54182-58-0
US $1.00 / kg 1kg 99% Customized career henan chemical co

54182-58-0(Sucralfate)Related Search:


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  • Sucralfate USP
  • AluMinuM,hexadeca-M-hydroxytetracosahydroxy[M8-[[1,3,4,6-tetra-O-sulfo-b-D-fructofuranosyl a-D-glucopyranosidetetrakis(sulfato-kO')](8-)]]hexadeca-
  • )hexadeca-
  • aluminum,hexadeca-u-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-o-sulfo-beta-d
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  • beta-d-fructofuranosyl-alpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-))
  • TRISENOX
  • 54182-58-0
  • 156-2-78
  • C12H30Al8O51S88H3AlO3
  • C12H54Al16O75S8
  • C11H52Al16O75S816
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