ChemicalBook >> CAS DataBase List >>4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL

CAS No.
805239-56-9
Chemical Name:
4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
Synonyms
PHTPP;4-[2-phenyl-5;5-a]pyrimidin-3-yl]phenol;7-bis(trifluoromethyl)pyrazolo[1;4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRA...;Inhibitor,inhibit,Estrogen Receptor/ERR,PHTPP;4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL;Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
CBNumber:
CB62453433
Molecular Formula:
C20H11F6N3O
Molecular Weight:
423.31
MDL Number:
MFCD09971112
MOL File:
805239-56-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Properties

storage temp. 2-8°C
solubility DMSO : 25 mg/mL (59.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form powder
color yellow to orange
FDA UNII NN82CVN36N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330
RIDADR  UN 2811 6.1 / PGIII
NFPA 704
0
2 0

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1355 PHTPP ≥98% (HPLC) 805239-56-9 5MG $129 2023-06-20 Buy
Sigma-Aldrich SML1355 PHTPP ≥98% (HPLC) 805239-56-9 25MG $507 2023-06-20 Buy
Cayman Chemical 16025 PHTPP ≥98% 805239-56-9 5mg $97 2024-03-01 Buy
Cayman Chemical 16025 PHTPP ≥98% 805239-56-9 10mg $184 2024-03-01 Buy
Cayman Chemical 16025 PHTPP ≥98% 805239-56-9 25mg $433 2024-03-01 Buy
Product number Packaging Price Buy
SML1355 5MG $129 Buy
SML1355 25MG $507 Buy
16025 5mg $97 Buy
16025 10mg $184 Buy
16025 25mg $433 Buy

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Chemical Properties,Uses,Production

Description

PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα. It exhibits no significant agonism on ERα or ERβ. This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype. At 100 pM, PHTPP has been found to enhance SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.

Uses

PHTPP can be used in pharmaceutical combination chemotherapy for treatment of cancer by exploiting estrogen receptor β (ERβ) and TP53 interaction.

Definition

ChEBI: 4-[2-phenyl-5,7-bis(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]phenol is a member of pyrazoles and a ring assembly.

Biological Activity

Selective estrogen ER β receptor antagonist that displays 36-fold selectivity over ER α . Exhibits full antagonism at ER β in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ER α .

Biochem/physiol Actions

PHTPP is a selective estrogen receptor β (ERβ) full antagonist with 36-fold selectivity for ERβ over ERα. PHTPP has been used to distinguish the various activites of the two estrogen receptors. Estrogen can have opposite effects in some tumors expressing ERα compared to Erβ, with Erα enhancing and Erβ suppressing tumor cell growth. PHTPP, a selective ERβ antagonist, significantly enhanced cell growth in ovarian cancer cell lines SKOV3 and OV2008 that express both receptors.

storage

Room temperature

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Spectrum

805239-56-9(4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL)Related Search:

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL PHTPP 4-[2-phenyl-5 5-a]pyrimidin-3-yl]phenol 7-bis(trifluoromethyl)pyrazolo[1 Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]- 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRA... Inhibitor,inhibit,Estrogen Receptor/ERR,PHTPP 805239-56-9 C20H11F6N3O