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Palbociclib

Palbociclib
Palbociclib structure
CAS No.
571190-30-2
Chemical Name:
Palbociclib
Synonyms
PD0332991;palboclib;Pab Xilib;albociclib;Pabuxilibu;Palbociclib; 571190-30-2;API-Anti-Tumer;albociclib API;Palbociclib-019
CBNumber:
CB62464897
Molecular Formula:
C24H29N7O2
Formula Weight:
447.54
MOL File:
571190-30-2.mol

Palbociclib Properties

Melting point:
200 ºC
Boiling point:
711.5±70.0 °C(Predicted)
Density 
1.313±0.06 g/cm3(Predicted)
storage temp. 
room temp
form 
powder
pka
8.66±0.10(Predicted)
color 
white to beige
FDA UNII
G9ZF61LE7G
NCI Dictionary of Cancer Terms
palbociclib

Palbociclib Chemical Properties,Uses,Production

Definition

ChEBI: A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combina ion with letrozole for the treatment of metastatic breast cancer.

Indications

Palbociclib (Ibrane(R), Pfizer), a selective CDK4 and CDK6 inhibitor, received accelerated approval from FDA in 2015 for women with estrogen receptor-positive and HER2-negative breast cancer in combination with letrozole.

Enzyme inhibitor

This orally active, non-ATP-competitive cyclin kinase-directed inhibitor (FW = 483.99 g/mol (mono-HCl); CASs = 827022-32-2 (mono- hydrochloride, 571190-30-2 (free base); Solubility: 10 mg/mL DMSO; 30 mg/mL Water; Formulation: Dissolved in sodium lactate buffer (50 mM, ® pH 4.0) ), also known as PD-0332991, Ibrance, and 6-acetyl-8-cyclopentyl- 5-methyl-2- (5- (piperazin-1-yl) pyridin-2-ylamino) pyrido[2,3-d]pyrimidin- 7 (8H) -one hydrochloride, targets Cdk-4 (Cyclin D1) and Cdk-6 (Cyclin D2), enzymes that participate in the so-called CDK4/6-retinoblastoma signaling pathway governing the cell-cycle restriction point. Palbociclib induces rapid G1 cell-cycle arrest in primary human myeloma cells. This agent also shows significant efficacy in a broad spectrum of human tumor xenografts in vivo, resulting in complete regression in some tumors with no evidence of acquired resistance or ability to circumvent the growth inhibitory properties of this agent. Ibrance received FDA approval in 2015 for combined use with letrozole to treat postmenopausal women with estrogen receptor- positive, (HER2) -negative advanced breast cancer as an initial endocrine- based therapy for metastatic disease. Cyclin Target Selectivity: Cdk1 (weak, if any), Cdk2 (weak, if any), Cdk3 (weak, if any), Cdk4 (IC50 = 11 nM), Cdk5 (weak, if any), Cdk6 (IC50 = 16 nM), Cdk7 (weak, if any), Cdk8 (weak, if any), Cdk9 (weak, if any), Cdk10 (weak, if any).

Palbociclib Preparation Products And Raw materials

Raw materials

Preparation Products


Palbociclib Suppliers

Global( 342)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3267 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55

View Lastest Price from Palbociclib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-16 Palbociclib
571190-30-2
US $0.00-0.00 / KG 1g 99% 100kg/month Beijing Yibai Biotechnology Co., Ltd
2019-07-05 OTAVA-BB 1115529
571190-30-2
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-10-25 Palbociclib
571190-30-2
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD

571190-30-2(Palbociclib)Related Search:


  • 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
  • Pyrido(2,3-D)pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-
  • PD 0332991;OTAVA-BB 1115529
  • 6-acetyl-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one
  • Palbociclib
  • OTAVA-BB 1115529/PD0332991
  • Palbociclib(PD0332991)
  • Palbociclib(free base)
  • PALBOCICLIB PD 0332991;OTAVA-BB 1115529
  • API-Anti-Tumer
  • 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-8H-PYRIDO
  • Palbociclib base
  • albociclib API
  • OTAVA-BB 1115529(571190-30-2)
  • Palbociclib-019
  • Palbociclib, >=98%
  • Prabhu past Lieb
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
  • OTAVA-BB 1115529
  • PD0332991
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
  • tert-butyl 4-(6-(8-cyclopentyl-5-Methyl-7-oxo-6-(1-propoxyvinyl)-7,8-dihydropyrido[2,3-d]pyriMidin-2-ylaMino)pyridin-3-yl)piperazine-1-carboxylate (CAS No.866084-31-3)
  • 571190-30-2
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-o
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)-pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyr
  • palbociclib (OTAVA-BB 1115529)
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-
  • 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylammino)-8H-pyrido-[2,3-d]-pyrimidin-7-one
  • palboclib
  • albociclib
  • PD0332991; PD-0332991; PD 0332991
  • Pab Xilib
  • Palbociclib API
  • Pabuxilibu
  • 571190-30-2
  • 16513214-74-2
  • API
  • Inhibitors
  • Anticancer
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