N-Tosyl-5-bromo-4,7-diazaindole
- CAS No.
- 1201186-54-0
- Chemical Name:
- N-Tosyl-5-bromo-4,7-diazaindole
- Synonyms
- 2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-5-[(4-methylphenyl)sulfonyl]-;Upatinib Impurity 2;Upatinib Impurity 45;Upadacitinib Impurity 2;Upadacitinib Impurity 45;N-Tosyl-5-bromo-4,7-diazaindole;Glycerol(Glycerophosphoric acid);3-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine;2-BROMO-5-(P-TOLYLSULFONYL)-5H-PYRROLO[2,3-B]PYRAZINE
- CBNumber:
- CB62470216
- Molecular Formula:
- C13H10BrN3O2S
- Molecular Weight:
- 352.21
- MDL Number:
- MFCD12964053
- MOL File:
- 1201186-54-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
N-Tosyl-5-bromo-4,7-diazaindole price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B679303 | 2-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine | 1201186-54-0 | 1g | $270 | 2021-12-16 | Buy |
TRC | B679303 | 2-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine | 1201186-54-0 | 2.5g | $550 | 2021-12-16 | Buy |
ChemScene | CS-W009203 | 2-Bromo-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine | 1201186-54-0 | 10g | $608 | 2021-12-16 | Buy |
Matrix Scientific | 073334 | N-Tosyl-5-bromo-4,7-diazaindole 95+% | 1201186-54-0 | 1g | $639 | 2021-12-16 | Buy |
ChemScene | CS-W009203 | 2-Bromo-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine | 1201186-54-0 | 1g | $120 | 2021-12-16 | Buy |
N-Tosyl-5-bromo-4,7-diazaindole Chemical Properties,Uses,Production
Uses
N-Tosyl-5-bromo-4,7-diazaindole is an intermediate of upadacitinib, known asupadacitinib intermediate, or upadacitinib impurity 2. As an inhibitor of Janus kinase1, upadacitinib selectively inhibits Janus kinase1 for immune system diseases such as psoriatic arthritis, rheumatoid arthritis, and Crohn's disease[1-3].
Preparation
A solution of anhydrous DMF (272 mL) dissolved with 2-bromo-5H-pyrrolo[2,3-b]pyrazine (78.0 g, 394 mmol) was configured. The temperature is maintained at 0-5 °C (within which the subsequent reaction has been maintained), and the solution was droppedly added to the sodium (12.8 g, 532 mmol) anhydrous DMF (543 mL) suspension in the stirred state within 60 minutes. The solution turned brown and the reaction solution was stirred for about 30 min. Then, within 60 minutes, anhydrous DMF (272 mL) dissolved with p-toluenesulfonyl chloride (94.0 g, 492 mmol) was added. After stirring the mixed solution for about 1 h, it was heated to ambient temperature and stirred for about 18 h. Slowly pour the reaction mixture into ice water (6 L) and added 2.5 N NaOH in water (50.0 mL, 125 mmol). Filter the sediment to collect and stirred 3 times with cold water (200 mL). Finally, the collected products were filtered and dried to a constant weight in a vacuum oven at about 55 °C to obtain N-Tosyl-5-bromo-4,7-diazaindole (134.6 g, 97%).
Safety
N-Tosyl-5-bromo-4,7-diazaindole can cause skin irritation, severe eye irritation, and possibly respiratory irritation.
References
[1] Yael Ross, Marina Magrey, Use of upadacitinib in the treatment of psoriatic arthritis, Immunotherapy, 2021, 13.
[2] Lina Serhal, Christopher J Edwards, Upadacitinib for the treatment of rheumatoid arthritis, Expert Review of Clinical Immunology, 2018, 15,13-25.
[3] Eleni Kotsiliti, Upadacitinib therapy for Crohn’s disease, Nature Reviews Gastroenterology & Hepatology, 2023, 20, 483.
N-Tosyl-5-bromo-4,7-diazaindole Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +8615064153060 | sales01@jndxj.com | China | 291 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Shanghai Jinghao Pharmaceutical Co.,Ltd | +86-21-68900963 | sales@jinghaopharma.com | CHINA | 153 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
Jinan Honest Pharm Co., Ltd | +8615318812076 | zpy8217@163.com | China | 286 | 58 |
Related articles
- What is Fmoc materialshdhdhd
- ddd
- Dec 12,2023
View Lastest Price from N-Tosyl-5-bromo-4,7-diazaindole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-02 | 2-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
1201186-54-0
|
US $300.00-7500.00 / KG | 0.1KG | 98% | 5MT per month | Anhui Dexinjia Biopharm Co., Ltd | ||
2024-08-28 | Upadacitinib Impurity 45
1201186-54-0
|
US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2024-04-11 | N-Tosyl-5-bromo-4,7-diazaindole
1201186-54-0
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
- 2-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
1201186-54-0
- US $300.00-7500.00 / KG
- 98%
- Anhui Dexinjia Biopharm Co., Ltd
- Upadacitinib Impurity 45
1201186-54-0
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- N-Tosyl-5-bromo-4,7-diazaindole
1201186-54-0
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd