CX-4945
- CAS No.
- 1009820-21-6
- Chemical Name:
- CX-4945
- Synonyms
- CX-4945;CS-1985;Silmitasertib;CX-4945, >=98%;CX-4945, CX4945;mitasertib (CX-4945);SPIROBIINDANE CX-4945;Silmitasertib(CX-4945);CX-4945 Silmitasertib;CX-4945 Silmitasertib CX4945
- CBNumber:
- CB62473893
- Molecular Formula:
- C19H12ClN3O2
- Molecular Weight:
- 349.77
- MDL Number:
- MFCD13184796
- MOL File:
- 1009820-21-6.mol
| Boiling point | 568.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.490 |
| storage temp. | Store at -20°C |
| solubility | ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | Orange powder. |
| pka | 2.96±0.30(Predicted) |
| FDA UNII | C6RWP0N0L2 |
CX-4945 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16779 | CX-4945 ≥98% | 1009820-21-6 | 500μg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16779 | CX-4945 ≥98% | 1009820-21-6 | 1mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16779 | CX-4945 ≥98% | 1009820-21-6 | 5mg | $206 | 2024-03-01 | Buy |
| Cayman Chemical | 16779 | CX-4945 ≥98% | 1009820-21-6 | 10mg | $346 | 2024-03-01 | Buy |
| TRC | C858600 | CX-4945 | 1009820-21-6 | 50mg | $910 | 2021-12-16 | Buy |
CX-4945 Chemical Properties,Uses,Production
Uses
CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.
Biological Activity
cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]
References
[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.
CX-4945 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
View Lastest Price from CX-4945 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png) |
2019-12-24 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid
1009820-21-6
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid
1009820-21-6
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
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