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JNJ-7706621

JNJ-7706621 structure

CAS No.: 443797-96-4

Chemical Name:: JNJ-7706621

Synonyms: CS-409;JNJ-7706621 USP/EP/BP;JNJ7706621; JNJ 7706621;Aurora Kinase/Cdk Inhibitor;JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor;Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide;Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-;Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase

CBNumber:: CB62484646

Molecular Formula:: C15H12F2N6O3S

Molecular Weight:: 394.36

MDL Number:: MFCD11100270

MOL File:: 443797-96-4.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:10

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JNJ-7706621 Properties

Melting point	149-155℃
Boiling point	676.6±65.0 °C(Predicted)
Density	1.71
storage temp.	+2C to +8C
solubility	Soluble in DMSO at 15mg/ml
form	White solid
pka	9.80±0.12(Predicted)
Sensitive	Light Sensitive
FDA UNII	74GK72DON8

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a

JNJ-7706621 price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	189406	Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem	443797-96-4	5mg	$403	2024-03-01	Buy
Alfa Aesar	J65997	Aurora Kinase/Cdk Inhibitor	443797-96-4	5mg	$379	2023-06-20	Buy
Cayman Chemical	18494	JNJ-7706621 ≥98%	443797-96-4	1mg	$44	2024-03-01	Buy
Cayman Chemical	18494	JNJ-7706621 ≥98%	443797-96-4	5mg	$193	2024-03-01	Buy
Cayman Chemical	18494	JNJ-7706621 ≥98%	443797-96-4	10mg	$341	2024-03-01	Buy

Product number	Packaging	Price	Buy
189406	5mg	$403	Buy
J65997	5mg	$379	Buy
18494	1mg	$44	Buy
18494	5mg	$193	Buy
18494	10mg	$341	Buy

JNJ-7706621 Chemical Properties,Uses,Production

Description

JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC₅₀s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity for these enzymes over a panel of other receptors and kinases, although it exhibits submicromolar inhibition of VEGF and FGF receptors, as well as GSK3β. JNJ-7706621 blocks the growth of a large variety of cancer cell lines (IC₅₀ values range from 112 to 514 nM), with lower potency against normal cells (IC₅₀ values between 3.67 and 5.42 μM). It induces the regression of A375 melanoma human tumor xenografts in mice. JNJ-7706621 is a substrate for the ATP-binding cassette transporter G2, also known as breast cancer resistance protein.

Uses

JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing''s sarcoma.

Definition

ChEBI: 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.

target

CDK1

JNJ-7706621 Preparation Products And Raw materials

Raw materials

Preparation Products

JNJ-7706621 Suppliers

Global( 114)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

JNJ-7706621 Spectrum

JNJ-7706621(443797-96-4)¹HNMR

443797-96-4(JNJ-7706621)Related Search:

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BI-D1870 CCT129202 AT9283

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4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ7706621 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide Aurora Kinase/Cdk Inhibitor Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem CS-409 JNJ7706621; JNJ 7706621 Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]- 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ-7706621 USP/EP/BP JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase 443797-96-4 C15H12F2N6O3S Inhibitor Inhibitors