Anacetrapib | 875446-37-0

Anacetrapib Properties

Boiling point	555.3±50.0 °C(Predicted)
Density	1.345
storage temp.	Store at -20°C
solubility	≥31.9 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
form	solid
pka	-2.30±0.60(Predicted)
FDA UNII	P7T269PR6S

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335-H302-H319

Precautionary statements

P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

NFPA 704

	0
2		0

Anacetrapib price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21558	Anacetrapib ≥98%	875446-37-0	1mg	$68	2024-03-01	Buy
Cayman Chemical	21558	Anacetrapib ≥98%	875446-37-0	5mg	$268	2024-03-01	Buy
Cayman Chemical	21558	Anacetrapib ≥98%	875446-37-0	10mg	$435	2024-03-01	Buy
Cayman Chemical	21558	Anacetrapib ≥98%	875446-37-0	25mg	$1002	2024-03-01	Buy
TRC	A637200	Anacetrapib	875446-37-0	25mg	$6720	2021-12-16	Buy

Product number	Packaging	Price	Buy
21558	1mg	$68	Buy
21558	5mg	$268	Buy
21558	10mg	$435	Buy
21558	25mg	$1002	Buy
A637200	25mg	$6720	Buy

Anacetrapib Chemical Properties,Uses,Production

Uses

An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.

Biological Activity

anacetrapib, also known as mk-0859, is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) that exhibits strong inhibition against cetp-mediated transfer of cholesteryl esters and triglycerides with values of inhibition constant ic50 of 16 nm and 29 nm respectively. anacetrapib is mainly metabolized by cyp3a4 through o-demethylation, hydroxylation on the biphenyl moiety and hydroxylation on the isopropyl side chain resulting in three oxidative metabolites m1, m2 and m3 respectively. anacetrapib is being investigated for the treatment of primary hypercholesterolemia and mixed hyperlipidemia due to its impressive effects to lower low-density lipoprotein (ldl) cholesterol levels and increase high-density lipoprotein (hdl) cholesterol levels without any associated major adverse events.tan ey, hartmann g, chen q, pereira a, bradley s, doss g, zhang as, ho jz, braun mp, dean dc, tang w, kumar s. pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. drug metab dispos. 2010;38(3):459-473.kumar s, tan ey, hartmann g, biddle z, bergman aj, dru j, ho jz, jones an, staskiewicz sj, braun mp, karanam b, dean dc, gendrano in, graves mw, wagner ja, krishna r. metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans. drug metab dispos. 2010;38(3):474-483

Enzyme inhibitor

This cholesteryl ester transfer protein (or CETP) inhibitor (FW = 637.51 g/mol; CAS 875446-37-0), also known by the code name MK-0859, reduces plasma cholesterol concentrations, thereby increasing serum highdensity lipoprotein levels and preventing cardiovascular disease associated with hypercholesteremia. X-ray crystal studies suggest that CETP is a crescent-shaped protein with a 6-nm hydrophobic tunnel traversing its core Both of the tunnel’s two entrances face the protein’s concave surface, which most likely is the interaction platform for binding HDL particles and engaging its lipoprotein constituents. CETP mediates the reciprocal transfer of neutral lipids (e.g., cholesteryl esters and triglycerides) and phospholipids between different lipoprotein fractions in blood plasma. Anacetrapib is unlike many CETP inhibitors, which increase systolic blood pressure. Anacetrapib also exhibits a low-to-moderate degree of absorption after oral dosing and majority of the absorbed dose is eliminated via oxidation to a series of hydroxylated metabolites that undergo conjugation with glucuronate before excretion into bile. Unlike torcetrapib, another CETP inhibitor, anacetrapib does not elevate blood pressure, alter electrolytes, or cause any significant side effects.

target

rhCETP

Anacetrapib synthesis

Synthesis of Anacetrapib from 2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-, (4S,5R)- and 4'-FLUORO-2'-METHOXY-5'-ISOPROPYL-4-TRIFLUOROMETHYL-1,1'-BIPHENYL-2-METHANOL

Anacetrapib Preparation Products And Raw materials

Raw materials

4'-FLUORO-2'-METHOXY-5'-ISOPROPYL-4-TRIFLUOROMETHYL-1,1'-BIPHENYL-2-METHANOL 2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-, (4S,5R)-

Preparation Products

Anacetrapib Suppliers

Global( 194)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Seasons Biotechnology Co., Ltd.	+86-0576-89232655 +86-13566878689	info@seasonsbio.com	China	46	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	283	58

Supplier	Advantage
Seasons Biotechnology Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
career henan chemical co	58
Biochempartner	58
Hangzhou Cyanochem Co., Ltd.	58

View Lastest Price from Anacetrapib manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-02	Anacetrapib 875446-37-0	US $70.00-700.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2023-10-26	Anacetrapib 875446-37-0	US $50.00-25.00 / kg	1kg	0.99	5 tons	Hebei Yanxi Chemical Co., Ltd.
2023-10-12	Anacetrapib 875446-37-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Anacetrapib
875446-37-0
US $70.00-700.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Anacetrapib
875446-37-0
US $50.00-25.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

Anacetrapib
875446-37-0
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Anacetrapib Spectrum

Anacetrapib(875446-37-0)¹HNMR

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5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

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(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)-4-methyl-1,3-oxazolidin-2-one Anacetrapib Mk0859 Mk-0859 Unii-p7T269pr6s (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one Anacetrapib(MK0859) 2-Oxazolidinone, 5-[3,5-bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-2'-Methoxy-5'-(1-Methylethyl)-4-(trifluoroMethyl)[1,1'-biphenyl]-2-yl]Methyl]-4-Methyl-, (4S,5R)- (4S,5R)-5-[3,5-Bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-2'-Methoxy-5'-(1-Methylethyl)-4-(trifluoroMethyl)[1,1'-biphenyl]-2-yl]Methyl]-4-Methyl-2-oxazolidinone (4S,5R)-5-[3,5-Bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-Methoxy-4 (4S,5R)-5-(3,5-bis(trifluoroMethyl)phenyl)-3-((4'-fluoro-2'-Methoxy-4-(trifluoroMethyl)-[1,1'-biphenyl]-2-yl)Methyl)-4-Methyloxazolidin-2-one (4S,5R)-5-(3,5-bis(trifluoroMethyl)phenyl)-3-((4-fluoro-5-isopropyl-2-Methoxy-4-(trifluoroMethyl)-[1,1-biphenyl]-2- Anacetripib (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one Anacetrapib (MK-0859) (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4-methyl-1,3-oxazolidin-2-one EZSolution Anacetrapib Anacetrapib, >=99% Timapiprant (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5- MK0859; MK-0859; MK 0859; ANACETRAPIB CS-66 MK-0859; MK 0859; MK0859 Anacetrapib USP/EP/BP (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-... Anacetrapib 13C6 TIANFUCHEM-- Anacetrapib (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-5-isopropyl-2-methoxy-phenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-oxazolidin-2-one (4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one 875446-37-0 C30H25F10NO3 Inhibitor CETP inhibitor Aromatics Chiral Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Anacetrapib