VEGFR2 Kinase Inhibitor II
- CAS No.
- 288144-20-7
- Chemical Name:
- VEGFR2 Kinase Inhibitor II
- Synonyms
- VEGFR2 Kinase Inhibitor II;VEGFR2 Kinase Inhibitor II,VEGFR-2 Kinase Inhibitor II;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem;(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one;2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-
- CBNumber:
- CB62501837
- Molecular Formula:
- C17H15BrN2O
- Molecular Weight:
- 343.22
- MDL Number:
- MFCD03453583
- MOL File:
- 288144-20-7.mol
Last updated:2023-05-18 11:31:15
| storage temp. | -20C |
|---|---|
| solubility | DMF: 20 mg/ml; DMSO: 10 mg/ml |
| form | Brown solid |
| FDA UNII | 9NPC24K8FA |
VEGFR2 Kinase Inhibitor II price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17544 | VEGFR2 Kinase Inhibitor II ≥95% | 288144-20-7 | 500μg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 17544 | VEGFR2 Kinase Inhibitor II ≥95% | 288144-20-7 | 1mg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 17544 | VEGFR2 Kinase Inhibitor II ≥95% | 288144-20-7 | 5mg | $661 | 2024-03-01 | Buy |
VEGFR2 Kinase Inhibitor II Chemical Properties,Uses,Production
General Description
A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 μM).
Biochem/physiol Actions
Cell permeable: yes
VEGFR2 Kinase Inhibitor II Preparation Products And Raw materials
Raw materials
Preparation Products
VEGFR2 Kinase Inhibitor II Suppliers
Global( 12)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
VEGFR2 Kinase Inhibitor II
(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one
VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem
2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-
VEGFR2 Kinase Inhibitor II,VEGFR-2 Kinase Inhibitor II
288144-20-7
Angiogenesis and Metastasis