5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
- CAS No.
- 17375-63-2
- Chemical Name:
- 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
- Synonyms
- BGC 20-761;5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine;1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl-
- CBNumber:
- CB62518824
- Molecular Formula:
- C19H22N2O
- Molecular Weight:
- 294.39
- MDL Number:
- MFCD18384954
- MOL File:
- 17375-63-2.mol
Boiling point | 489.2±45.0 °C(Predicted) |
---|---|
Density | 1.114±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | <14.72mg/ml in ethanol; <29.44mg/ml in DMSO |
form | solid |
pka | 16.74±0.30(Predicted) |
color | White |
FDA UNII | 6G5F6ESV5I |
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 3326 | BGC20-761 ≥98%(HPLC) | 17375-63-2 | 10 | $185 | 2021-12-16 | Buy |
Usbiological | 254743 | BGC 20-761 | 17375-63-2 | 10mg | $446 | 2021-12-16 | Buy |
TRC | B366755 | BGC20-761 | 17375-63-2 | 1mg | $105 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0007598 | BGC 20-761 95.00% | 17375-63-2 | 5MG | $505.35 | 2021-12-16 | Buy |
ApexBio Technology | B7366 | BGC20-761 | 17375-63-2 | 10mg | $282 | 2021-12-16 | Buy |
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Chemical Properties,Uses,Production
Uses
BGC 20-761, is a selective high affinity 5-HT6 antagonist (Ki = 20 nM). that has shown to enhance memory consolidation in a rat model. It reverses he amnesic effects of Scopolamine (S200000).
Biological Activity
bgc20-761 is a selective and high affinity antagonist of 5-htc.the 5-ht6 receptor, a g protein-coupled receptor (gpcr), is a subtype of 5-ht receptor which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-ht). this protein is expressed almost exclusively in the brain and mediates excitatory neurotransmission.in cellular level, bgc20-761 (5-methoxy-2-phenyl-n,n-dimethyltryptamine) was shown to selectively blocked 5-htc.bgc20-761 was used to study the difference in drug- induced effects in memory consolidation in young and mature rats and human. in young mice, bgc20-761 treatment at doses of 5 mg/kg and 10 mg/kg i.p, dose-dependently reversed a deficit of social recognition induced by scopolamine, an anticholinergic drug that impairs memory at dosage of 0.4 mg/kg i.p. in mature rats (6 months), recognition of the novel object was improved following administration of bgc20-761. the difference in effects of bgc20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges 1.
storage
Store at +4°C
References
1. mitchell es, hoplight bj, lear sp, et al. bgc20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-ht6 receptor-mediated mechanism. neuropharmacology. 2006;50(4):412-420.
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4028 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |