ChemicalBook >> CAS DataBase List >>5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide structure

CAS No.: 511296-88-1

Chemical Name:: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

Synonyms: PFT-β;CS-1771;HY-16702A;Pifithrin B;Pifithrin-β;Cyclic PFT-α;Cyclic PFT-α;Pifithrin-beta;Cyclic Pifithrin-α;Pifithrin-β(PPT-β)

CBNumber:: CB62518925

Molecular Formula:: C16H16N2S.HBr

Molecular Weight:: 349

MDL Number:: MFCD02683960

MOL File:: 511296-88-1.mol

MSDS File:: SDS

Last updated:2023-09-04 16:42:00

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5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Properties

storage temp.	-20°C
solubility	DMSO: soluble20mg/mL
form	powder to crystal
color	White to Almost white
Merck	14,7421
FDA UNII	UP003XXT4D

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2934.99.4400

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P4236	Cyclic Pifithrin-α hydrobromide ≥98% (HPLC)	511296-88-1	5mg	$200	2024-03-01	Buy
Sigma-Aldrich	P4236	Cyclic Pifithrin-α hydrobromide ≥98% (HPLC)	511296-88-1	10mg	$336	2024-03-01	Buy
TCI Chemical	C2826	Cyclic Pifithrin-alpha Hydrobromide >98.0%(HPLC)	511296-88-1	20mg	$336	2023-01-07	Buy
TCI Chemical	C2826	Cyclic Pifithrin-alpha Hydrobromide >98.0%(HPLC)	511296-88-1	100mg	$805	2024-03-01	Buy
Cayman Chemical	14748	Cyclic Pifithrin-α (hydrobromide) ≥95%	511296-88-1	5mg	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
P4236	5mg	$200	Buy
P4236	10mg	$336	Buy
C2826	20mg	$336	Buy
C2826	100mg	$805	Buy
14748	5mg	$57	Buy

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Chemical Properties,Uses,Production

Description

Pifithrin-α (PFT-α; ) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC₅₀ = 23, 77, and 103 μM, respectively). At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents. In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.

Uses

Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke?induced apoptosis of pulmonary endothelial cells.

Biochem/physiol Actions

A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.

in vitro

pifithrin-α blocks p53-dependent transactivation of p53-responsive genes in cona cells. pifithrin-α (10 μm) inhibits apoptotic death of c8 cells guided by etoposide, taxol, dox, cytosine arabinoside. pifithrin-α has significant effect on the inhibition of p53-dependent growth arrest of human diploid fibroblasts in response to dna damage but not on p53-deficient fibroblasts. pifithrin-α may monitor the nuclear import or export (or both) of p53 or may make nuclear p53 instability [2].

in vivo

pifithrin-α-mice (2.2 mg/kg i.p.) were completely survival with both strains from 60% killing doses of gamma irradiation (8 gy for c57bl and 6 gy for balb/c). mice pretreated with pfithrin-α lost less weight than irradiated mice without the pifithrin-α. pifithrin-α (2.2 mg/kg) eliminates p53-dependent regulation of dna replication after whole-body gamma irradiation in mice [2].

storage

Desiccate at RT

References

[1] komarova ea and gudkov a v. could p53 be a target for therapeutic suppression semin. cancer biol. 1998, 8: 389-400.
[2] komarov pg, komarova ea, kondratov rv, christov-tselkov k, coon js, chernov mv, gudkov av. a chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. science. 1999 sep 10; 285(5434):1733-7.

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Suppliers

Global( 91)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-23	5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide 511296-88-1	US $1.00 / g	1g	99.99%	200kg	Career Henan Chemical Co

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
511296-88-1
US $1.00 / g
99.99%
Career Henan Chemical Co

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Spectrum

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide(511296-88-1)MS 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide(511296-88-1)¹HNMR

511296-88-1(5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide)Related Search:

2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Citalopram hydrobromide Ascorbic Acid

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Cyclic Pifithrin-α hydrobromide Pifithrin-beta Cyclic Pifithrin-alpha HydrobroMide 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Pifithrin-β 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide Cyclic PFT-α hydrobromide Pifithrin-α, cyclic Cyclic Pifithrin-α HBr Pifithrin- beta hydrobromide Cyclic PFT-α Pifithrin B PIFITHRIN-Β;PIFITHRIN B;CYCLIC PFT-Α; PIFITHRIN-Β; PFT-Β CS-1771 CYCLIC PIFITHRIN-Α HYDROBROMIDE;CYCLIC PFT-Α HYDROBROMIDE;PFT-Β HYDROBROMIDE HY-16702A Cyclic Pifithrin-α Hydrobromide > Pifithrin-β Cyclic Pifithrin-α 2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide Pifithrin-α, Cyclic, hydrobromide Pifithrin-β hydrobromide Pifithrin-β HBr (QB102 Cyclic Pifithrin-α Hydrobromide Cyclic PFT-α PFT β (hydrobromide) PFT-β 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole hydrobromide Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1) 5,6,7,8-tetrahydro-2-(4-methylphenyl)-Imidazo[2,1-b]benzothiazole hydrobromide (1:1) inhibit,MDM-2/p53,Pifithrinβ hydrobromide,Ferroptosis,Pifithrin β hydrobromide,Cyclic Pifithrin-α,Inhibitor,PFT β Pifithrin-β(PPT-β) 511296-88-1 C16H16N2SHBr C16H16N2SBrH